B-Virus (Cercopithecine herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease
Nonhuman primates are widely used in biomedical research because of their genetic, anatomic, and physiologic similarities to humans. In this setting, human contact directly with macaques or with their tissues and fluids sometimes occurs. Cercopithecine herpesvirus 1 (B virus), an alphaherpesvirus en...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2003-02-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/9/2/02-0272_article |
| _version_ | 1811261951547801600 |
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| author | Jennifer L. Huff Peter A. Barry |
| author_facet | Jennifer L. Huff Peter A. Barry |
| author_sort | Jennifer L. Huff |
| collection | DOAJ |
| description | Nonhuman primates are widely used in biomedical research because of their genetic, anatomic, and physiologic similarities to humans. In this setting, human contact directly with macaques or with their tissues and fluids sometimes occurs. Cercopithecine herpesvirus 1 (B virus), an alphaherpesvirus endemic in Asian macaques, is closely related to herpes simplex virus (HSV). Most macaques carry B virus without overt signs of disease. However, zoonotic infection with B virus in humans usually results in fatal encephalomyelitis or severe neurologic impairment. Although the incidence of human infection with B virus is low, a death rate of >70% before the availability of antiviral therapy makes this virus a serious zoonotic threat. Knowledge of the clinical signs and risk factors for human B-virus disease allows early initiation of antiviral therapy and prevents severe disease or death. |
| first_indexed | 2024-04-12T19:16:06Z |
| format | Article |
| id | doaj.art-aff3f2411c6f4d72bdc901c13a0f0c70 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-12T19:16:06Z |
| publishDate | 2003-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-aff3f2411c6f4d72bdc901c13a0f0c702022-12-22T03:19:45ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592003-02-019224625010.3201/eid0902.020272B-Virus (Cercopithecine herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic DiseaseJennifer L. HuffPeter A. BarryNonhuman primates are widely used in biomedical research because of their genetic, anatomic, and physiologic similarities to humans. In this setting, human contact directly with macaques or with their tissues and fluids sometimes occurs. Cercopithecine herpesvirus 1 (B virus), an alphaherpesvirus endemic in Asian macaques, is closely related to herpes simplex virus (HSV). Most macaques carry B virus without overt signs of disease. However, zoonotic infection with B virus in humans usually results in fatal encephalomyelitis or severe neurologic impairment. Although the incidence of human infection with B virus is low, a death rate of >70% before the availability of antiviral therapy makes this virus a serious zoonotic threat. Knowledge of the clinical signs and risk factors for human B-virus disease allows early initiation of antiviral therapy and prevents severe disease or death.https://wwwnc.cdc.gov/eid/article/9/2/02-0272_articleCercopithecine herpesvirus 1B virusherpes Bmonkey B virusHerpesvirus simiaealphaherpesvirus |
| spellingShingle | Jennifer L. Huff Peter A. Barry B-Virus (Cercopithecine herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease Emerging Infectious Diseases Cercopithecine herpesvirus 1 B virus herpes B monkey B virus Herpesvirus simiae alphaherpesvirus |
| title | B-Virus (Cercopithecine herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease |
| title_full | B-Virus (Cercopithecine herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease |
| title_fullStr | B-Virus (Cercopithecine herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease |
| title_full_unstemmed | B-Virus (Cercopithecine herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease |
| title_short | B-Virus (Cercopithecine herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease |
| title_sort | b virus cercopithecine herpesvirus 1 infection in humans and macaques potential for zoonotic disease |
| topic | Cercopithecine herpesvirus 1 B virus herpes B monkey B virus Herpesvirus simiae alphaherpesvirus |
| url | https://wwwnc.cdc.gov/eid/article/9/2/02-0272_article |
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