In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol
Background: The developing fetus is particularly vulnerable to the effects of endocrine disrupting chemicals (EDCs). Molecular fingerprints of EDCs can be identified via microRNA (miRNA) expression profiles and may be etiologically implicated in the developmental origin of disease (DOHaD). Methods/...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-09-01
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| Series: | Journal of Public Health Research |
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| Online Access: | https://www.jphres.org/index.php/jphres/article/view/1550 |
| _version_ | 1797971093396389888 |
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| author | Tricia L. Larose Pål Sætrom Marit P. Martinussen Håkon Skogseth Torkjel M. Sandanger Ghislaine Scelo Cliona M. McHale Geir W. Jacobsen Martyn T. Smith |
| author_facet | Tricia L. Larose Pål Sætrom Marit P. Martinussen Håkon Skogseth Torkjel M. Sandanger Ghislaine Scelo Cliona M. McHale Geir W. Jacobsen Martyn T. Smith |
| author_sort | Tricia L. Larose |
| collection | DOAJ |
| description | Background: The developing fetus is particularly vulnerable to the effects of endocrine disrupting chemicals (EDCs). Molecular fingerprints of EDCs can be identified via microRNA (miRNA) expression profiles and may be etiologically implicated in the developmental origin of disease (DOHaD).
Methods/design: This pilot study includes pregnant women at high risk (smoking at conception), and low risk (non-smoking at conception) for SGA birth (birthweight<10th percentile for gestational age). We have randomly selected 12 mothers (3 high-risk SGA birth, 3 low-risk SGA birth, 3 high-risk non-SGA birth, 3 low-risk non-SGA birth), with EDC measurements from gestational week 17. All offspring are female. We aim to test the stability of our samples (maternal serum, cord blood, placenta tissue), observe the differential expression of miRNA profiles over time (gestational weeks 17, 25, 33, 37, birth), and study the consistency between maternal EDC measures and miRNA expression profiles across our repeated measures.
Expected impact of the study for Public Health: Results from this pilot study will inform the development of a larger cohort wide analysis, and will impact the current state of knowledge in the fields of public health, epigenetics, and the DOHaD. |
| first_indexed | 2024-04-11T03:27:15Z |
| format | Article |
| id | doaj.art-aff491e4ffc0439786fc221235f63abf |
| institution | Directory Open Access Journal |
| issn | 2279-9028 2279-9036 |
| language | English |
| last_indexed | 2024-04-11T03:27:15Z |
| publishDate | 2019-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Public Health Research |
| spelling | doaj.art-aff491e4ffc0439786fc221235f63abf2023-01-02T07:13:53ZengSAGE PublishingJournal of Public Health Research2279-90282279-90362019-09-018210.4081/jphr.2019.1550In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocolTricia L. Larose0Pål Sætrom1Marit P. Martinussen2Håkon Skogseth3Torkjel M. Sandanger4Ghislaine Scelo5Cliona M. McHale6Geir W. Jacobsen7Martyn T. Smith8K.G. Jebsen Center for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim1K.G. Jebsen Center for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim; Department of Computer Science, Faculty of Information Technology and Electrical Engineering, Norwegian University of Science and Technology, Trondheim; Bioinformatics core facility – BioCore, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, TrondheimDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, TrondheimBiobank 1, St. Olavs University Hospital, TrondheimDepartment of Community Medicine, Faculty of Health Sciences, UiT-the Arctic University of Norway, TromsøGenetic Epidemiology Group, Section of Genetics, International Agency for Research on Cancer, World Health Organization, LyonDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CADepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, TrondheimDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CABackground: The developing fetus is particularly vulnerable to the effects of endocrine disrupting chemicals (EDCs). Molecular fingerprints of EDCs can be identified via microRNA (miRNA) expression profiles and may be etiologically implicated in the developmental origin of disease (DOHaD). Methods/design: This pilot study includes pregnant women at high risk (smoking at conception), and low risk (non-smoking at conception) for SGA birth (birthweight<10th percentile for gestational age). We have randomly selected 12 mothers (3 high-risk SGA birth, 3 low-risk SGA birth, 3 high-risk non-SGA birth, 3 low-risk non-SGA birth), with EDC measurements from gestational week 17. All offspring are female. We aim to test the stability of our samples (maternal serum, cord blood, placenta tissue), observe the differential expression of miRNA profiles over time (gestational weeks 17, 25, 33, 37, birth), and study the consistency between maternal EDC measures and miRNA expression profiles across our repeated measures. Expected impact of the study for Public Health: Results from this pilot study will inform the development of a larger cohort wide analysis, and will impact the current state of knowledge in the fields of public health, epigenetics, and the DOHaD.https://www.jphres.org/index.php/jphres/article/view/1550environmental healthendocrine disrupting chemicalsfetal growthmiRNA |
| spellingShingle | Tricia L. Larose Pål Sætrom Marit P. Martinussen Håkon Skogseth Torkjel M. Sandanger Ghislaine Scelo Cliona M. McHale Geir W. Jacobsen Martyn T. Smith In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol Journal of Public Health Research environmental health endocrine disrupting chemicals fetal growth miRNA |
| title | In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol |
| title_full | In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol |
| title_fullStr | In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol |
| title_full_unstemmed | In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol |
| title_short | In utero exposure to endocrine disrupting chemicals, micro-RNA profiles, and fetal growth: a pilot study protocol |
| title_sort | in utero exposure to endocrine disrupting chemicals micro rna profiles and fetal growth a pilot study protocol |
| topic | environmental health endocrine disrupting chemicals fetal growth miRNA |
| url | https://www.jphres.org/index.php/jphres/article/view/1550 |
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