Description of a Cohort of Type 1 Diabetes Patients: Analysis of Comorbidities, Prevalence of Complications and Risk of Hypoglycemia
Background: Despite major medical advances, Type 1 Diabetes (T1D) patients still have greater morbimortality than the general population. Our aim was to describe our cohort of T1D patients and identify potential risk factors susceptible to prevention strategies. Methods: Cross-sectional, observation...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/4/1039 |
| _version_ | 1797479133176922112 |
|---|---|
| author | Antonio J. Martínez-Ortega Cristina Muñoz-Gómez Noelia Gros-Herguido Pablo Jesús Remón-Ruiz Domingo Acosta-Delgado Fernando Losada-Viñau Alfonso Pumar-López Miguel Ángel Mangas-Cruz Irene González-Navarro Gema López-Gallardo Virginia Bellido Alfonso Manuel Soto-Moreno |
| author_facet | Antonio J. Martínez-Ortega Cristina Muñoz-Gómez Noelia Gros-Herguido Pablo Jesús Remón-Ruiz Domingo Acosta-Delgado Fernando Losada-Viñau Alfonso Pumar-López Miguel Ángel Mangas-Cruz Irene González-Navarro Gema López-Gallardo Virginia Bellido Alfonso Manuel Soto-Moreno |
| author_sort | Antonio J. Martínez-Ortega |
| collection | DOAJ |
| description | Background: Despite major medical advances, Type 1 Diabetes (T1D) patients still have greater morbimortality than the general population. Our aim was to describe our cohort of T1D patients and identify potential risk factors susceptible to prevention strategies. Methods: Cross-sectional, observational study, including T1D patients treated at our center, from 1 March 2017 to 31 March 2020. Inclusion criteria: T1D, age > 14 years and signed informed consent. Exclusion criteria: diabetes other than T1D, age < 14 years and/or refusal to participate. Results: Study population <i>n</i> = 2181 (49.8% females, median age at enrollment 41 years, median HbA1c 7.7%; 38.24% had at least one comorbidity). Roughly 7.45% had severe hypoglycemia (SH) within the prior year. Macro/microvascular complications were present in 42.09% (5.83% and 41.14%, respectively). The most frequent microvascular complication was diabetic retinopathy (38.02%), and coronary disease (3.21%) was the most frequent macrovascular complication. The risk of complications was higher in males than in females, mainly macrovascular. Patients with SH had a higher risk of complications (OR 1.42; 1.43 in males versus 1.42 in females). Conclusions: Our T1D population is similar to other T1D populations. We should minimize the risk of SH, and male patients should perhaps be treated more aggressively regarding cardiovascular risk factors. |
| first_indexed | 2024-03-09T21:41:15Z |
| format | Article |
| id | doaj.art-aff5b041718a43e69009c31370318627 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T21:41:15Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-aff5b041718a43e69009c313703186272023-11-23T20:30:45ZengMDPI AGJournal of Clinical Medicine2077-03832022-02-01114103910.3390/jcm11041039Description of a Cohort of Type 1 Diabetes Patients: Analysis of Comorbidities, Prevalence of Complications and Risk of HypoglycemiaAntonio J. Martínez-Ortega0Cristina Muñoz-Gómez1Noelia Gros-Herguido2Pablo Jesús Remón-Ruiz3Domingo Acosta-Delgado4Fernando Losada-Viñau5Alfonso Pumar-López6Miguel Ángel Mangas-Cruz7Irene González-Navarro8Gema López-Gallardo9Virginia Bellido10Alfonso Manuel Soto-Moreno11Endocrinology and Nutrition Department, Virgen del Rocío University Hospital, Manuel Siurot Av., 41013 Seville, SpainEndocrinology and Nutrition Department, Virgen del Rocío University Hospital, Manuel Siurot Av., 41013 Seville, SpainEndocrinology and Nutrition Department, Virgen del Rocío University Hospital, Manuel Siurot Av., 41013 Seville, SpainEndocrinology and Nutrition Department, Virgen del Rocío University Hospital, Manuel Siurot Av., 41013 Seville, SpainEndocrinology and Nutrition Department, Virgen del Rocío University Hospital, Manuel Siurot Av., 41013 Seville, SpainEndocrinology and Nutrition Department, Virgen del Rocío University Hospital, Manuel Siurot Av., 41013 Seville, SpainEndocrinology and Nutrition Department, Virgen del Rocío University Hospital, Manuel Siurot Av., 41013 Seville, SpainEndocrinology and Nutrition Department, Virgen del Rocío University Hospital, Manuel Siurot Av., 41013 Seville, SpainEndocrinology and Nutrition Department, Virgen del Rocío University Hospital, Manuel Siurot Av., 41013 Seville, SpainEndocrinology and Nutrition Department, Virgen del Rocío University Hospital, Manuel Siurot Av., 41013 Seville, SpainEndocrinology and Nutrition Department, Virgen del Rocío University Hospital, Manuel Siurot Av., 41013 Seville, SpainEndocrinology and Nutrition Department, Virgen del Rocío University Hospital, Manuel Siurot Av., 41013 Seville, SpainBackground: Despite major medical advances, Type 1 Diabetes (T1D) patients still have greater morbimortality than the general population. Our aim was to describe our cohort of T1D patients and identify potential risk factors susceptible to prevention strategies. Methods: Cross-sectional, observational study, including T1D patients treated at our center, from 1 March 2017 to 31 March 2020. Inclusion criteria: T1D, age > 14 years and signed informed consent. Exclusion criteria: diabetes other than T1D, age < 14 years and/or refusal to participate. Results: Study population <i>n</i> = 2181 (49.8% females, median age at enrollment 41 years, median HbA1c 7.7%; 38.24% had at least one comorbidity). Roughly 7.45% had severe hypoglycemia (SH) within the prior year. Macro/microvascular complications were present in 42.09% (5.83% and 41.14%, respectively). The most frequent microvascular complication was diabetic retinopathy (38.02%), and coronary disease (3.21%) was the most frequent macrovascular complication. The risk of complications was higher in males than in females, mainly macrovascular. Patients with SH had a higher risk of complications (OR 1.42; 1.43 in males versus 1.42 in females). Conclusions: Our T1D population is similar to other T1D populations. We should minimize the risk of SH, and male patients should perhaps be treated more aggressively regarding cardiovascular risk factors.https://www.mdpi.com/2077-0383/11/4/1039Type 1 Diabetesmacrovascular complicationsmicrovascular complicationssevere hypoglycemia |
| spellingShingle | Antonio J. Martínez-Ortega Cristina Muñoz-Gómez Noelia Gros-Herguido Pablo Jesús Remón-Ruiz Domingo Acosta-Delgado Fernando Losada-Viñau Alfonso Pumar-López Miguel Ángel Mangas-Cruz Irene González-Navarro Gema López-Gallardo Virginia Bellido Alfonso Manuel Soto-Moreno Description of a Cohort of Type 1 Diabetes Patients: Analysis of Comorbidities, Prevalence of Complications and Risk of Hypoglycemia Journal of Clinical Medicine Type 1 Diabetes macrovascular complications microvascular complications severe hypoglycemia |
| title | Description of a Cohort of Type 1 Diabetes Patients: Analysis of Comorbidities, Prevalence of Complications and Risk of Hypoglycemia |
| title_full | Description of a Cohort of Type 1 Diabetes Patients: Analysis of Comorbidities, Prevalence of Complications and Risk of Hypoglycemia |
| title_fullStr | Description of a Cohort of Type 1 Diabetes Patients: Analysis of Comorbidities, Prevalence of Complications and Risk of Hypoglycemia |
| title_full_unstemmed | Description of a Cohort of Type 1 Diabetes Patients: Analysis of Comorbidities, Prevalence of Complications and Risk of Hypoglycemia |
| title_short | Description of a Cohort of Type 1 Diabetes Patients: Analysis of Comorbidities, Prevalence of Complications and Risk of Hypoglycemia |
| title_sort | description of a cohort of type 1 diabetes patients analysis of comorbidities prevalence of complications and risk of hypoglycemia |
| topic | Type 1 Diabetes macrovascular complications microvascular complications severe hypoglycemia |
| url | https://www.mdpi.com/2077-0383/11/4/1039 |
| work_keys_str_mv | AT antoniojmartinezortega descriptionofacohortoftype1diabetespatientsanalysisofcomorbiditiesprevalenceofcomplicationsandriskofhypoglycemia AT cristinamunozgomez descriptionofacohortoftype1diabetespatientsanalysisofcomorbiditiesprevalenceofcomplicationsandriskofhypoglycemia AT noeliagrosherguido descriptionofacohortoftype1diabetespatientsanalysisofcomorbiditiesprevalenceofcomplicationsandriskofhypoglycemia AT pablojesusremonruiz descriptionofacohortoftype1diabetespatientsanalysisofcomorbiditiesprevalenceofcomplicationsandriskofhypoglycemia AT domingoacostadelgado descriptionofacohortoftype1diabetespatientsanalysisofcomorbiditiesprevalenceofcomplicationsandriskofhypoglycemia AT fernandolosadavinau descriptionofacohortoftype1diabetespatientsanalysisofcomorbiditiesprevalenceofcomplicationsandriskofhypoglycemia AT alfonsopumarlopez descriptionofacohortoftype1diabetespatientsanalysisofcomorbiditiesprevalenceofcomplicationsandriskofhypoglycemia AT miguelangelmangascruz descriptionofacohortoftype1diabetespatientsanalysisofcomorbiditiesprevalenceofcomplicationsandriskofhypoglycemia AT irenegonzaleznavarro descriptionofacohortoftype1diabetespatientsanalysisofcomorbiditiesprevalenceofcomplicationsandriskofhypoglycemia AT gemalopezgallardo descriptionofacohortoftype1diabetespatientsanalysisofcomorbiditiesprevalenceofcomplicationsandriskofhypoglycemia AT virginiabellido descriptionofacohortoftype1diabetespatientsanalysisofcomorbiditiesprevalenceofcomplicationsandriskofhypoglycemia AT alfonsomanuelsotomoreno descriptionofacohortoftype1diabetespatientsanalysisofcomorbiditiesprevalenceofcomplicationsandriskofhypoglycemia |