Donor T cell STAT3 deficiency enables tissue PD-L1–dependent prevention of graft-versus-host disease while preserving graft-versus-leukemia activity
STAT3 deficiency (STAT3–/–) in donor T cells prevents graft-versus-host disease (GVHD), but the impact on graft-versus-leukemia (GVL) activity and mechanisms of GVHD prevention remains unclear. Here, using murine models of GVHD, we show that STAT3–/– donor T cells induced only mild reversible acute...
Main Authors: | Qinjian Li, Xiaoqi Wang, Qingxiao Song, Shijie Yang, Xiwei Wu, Dongyun Yang, Isabelle J. Marié, Hanjun Qin, Moqian Zheng, Ubaydah Nasri, Xiaohui Kong, Bixin Wang, Elizabeth Lizhar, Kaniel Cassady, Josh Tompkins, David Levy, Paul J. Martin, Xi Zhang, Defu Zeng |
---|---|
Format: | Article |
Language: | English |
Published: |
American Society for Clinical Investigation
2023-08-01
|
Series: | The Journal of Clinical Investigation |
Subjects: | |
Online Access: | https://doi.org/10.1172/JCI165723 |
Similar Items
-
Having it both ways: how STAT3 deficiency blocks graft-versus-host disease while preserving graft-versus-leukemia activity
by: Joshua D. Brandstadter, et al.
Published: (2023-08-01) -
Targeting Histone Deacetylases to Modulate Graft-Versus-Host Disease and Graft-Versus-Leukemia
by: Sena Kim, et al.
Published: (2020-06-01) -
Recent advances in ocular graft-versus-host disease
by: Xianjing Cheng, et al.
Published: (2023-01-01) -
Formaldehyde-treated temporofascial graft versus cartilage graft in repairing failed tympanic membrane grafting
by: Mostafa O. Ramadan, et al.
Published: (2017-10-01) -
The graft-versus-leukemia effect in AML
by: Sweeney, C, et al.
Published: (2019)