Protein palmitoylation in cancer: molecular functions and therapeutic potential
Protein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing (ZDHHC) protein family. The reverse reaction, depalmitoylation, is catalyzed by palmitoyl‐protein thioesterases (PPTs),...
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Format: | Article |
Language: | English |
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Wiley
2023-01-01
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Series: | Molecular Oncology |
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Online Access: | https://doi.org/10.1002/1878-0261.13308 |
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author | Binhui Zhou Qianyun Hao Yinming Liang Eryan Kong |
author_facet | Binhui Zhou Qianyun Hao Yinming Liang Eryan Kong |
author_sort | Binhui Zhou |
collection | DOAJ |
description | Protein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing (ZDHHC) protein family. The reverse reaction, depalmitoylation, is catalyzed by palmitoyl‐protein thioesterases (PPTs), including acyl‐protein thioesterases (APT1/2), palmitoyl protein thioesterases (PPT1/2), or alpha/beta hydrolase domain‐containing protein 17A/B/C (ABHD17A/B/C). Proteins encoded by several oncogenes and tumor suppressors are modified by palmitoylation, which enhances the hydrophobicity of specific protein subdomains, and can confer changes in protein stability, membrane localization, protein–protein interaction, and signal transduction. The importance for protein palmitoylation in tumorigenesis has just started to be elucidated in the past decade; palmitoylation appears to affect key aspects of cancer, including cancer cell proliferation and survival, cell invasion and metastasis, and antitumor immunity. Here we review the current literature on protein palmitoylation in the various cancer types, and discuss the potential of targeting of palmitoylation enzymes or palmitoylated proteins for tumor treatment. |
first_indexed | 2024-04-11T00:56:49Z |
format | Article |
id | doaj.art-aff7ac389f314689b431524ece95b62a |
institution | Directory Open Access Journal |
issn | 1574-7891 1878-0261 |
language | English |
last_indexed | 2024-04-11T00:56:49Z |
publishDate | 2023-01-01 |
publisher | Wiley |
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series | Molecular Oncology |
spelling | doaj.art-aff7ac389f314689b431524ece95b62a2023-01-05T03:41:33ZengWileyMolecular Oncology1574-78911878-02612023-01-0117132610.1002/1878-0261.13308Protein palmitoylation in cancer: molecular functions and therapeutic potentialBinhui Zhou0Qianyun Hao1Yinming Liang2Eryan Kong3Institute of Psychiatry and Neuroscience Xinxiang Medical University ChinaKey laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Thoracic Oncology II Peking University Cancer Hospital & Institute Beijing ChinaInstitute of Psychiatry and Neuroscience Xinxiang Medical University ChinaInstitute of Psychiatry and Neuroscience Xinxiang Medical University ChinaProtein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing (ZDHHC) protein family. The reverse reaction, depalmitoylation, is catalyzed by palmitoyl‐protein thioesterases (PPTs), including acyl‐protein thioesterases (APT1/2), palmitoyl protein thioesterases (PPT1/2), or alpha/beta hydrolase domain‐containing protein 17A/B/C (ABHD17A/B/C). Proteins encoded by several oncogenes and tumor suppressors are modified by palmitoylation, which enhances the hydrophobicity of specific protein subdomains, and can confer changes in protein stability, membrane localization, protein–protein interaction, and signal transduction. The importance for protein palmitoylation in tumorigenesis has just started to be elucidated in the past decade; palmitoylation appears to affect key aspects of cancer, including cancer cell proliferation and survival, cell invasion and metastasis, and antitumor immunity. Here we review the current literature on protein palmitoylation in the various cancer types, and discuss the potential of targeting of palmitoylation enzymes or palmitoylated proteins for tumor treatment.https://doi.org/10.1002/1878-0261.13308cancer treatmentoncogeneprotein S‐palmitoylationtumor suppressortumorigenesis |
spellingShingle | Binhui Zhou Qianyun Hao Yinming Liang Eryan Kong Protein palmitoylation in cancer: molecular functions and therapeutic potential Molecular Oncology cancer treatment oncogene protein S‐palmitoylation tumor suppressor tumorigenesis |
title | Protein palmitoylation in cancer: molecular functions and therapeutic potential |
title_full | Protein palmitoylation in cancer: molecular functions and therapeutic potential |
title_fullStr | Protein palmitoylation in cancer: molecular functions and therapeutic potential |
title_full_unstemmed | Protein palmitoylation in cancer: molecular functions and therapeutic potential |
title_short | Protein palmitoylation in cancer: molecular functions and therapeutic potential |
title_sort | protein palmitoylation in cancer molecular functions and therapeutic potential |
topic | cancer treatment oncogene protein S‐palmitoylation tumor suppressor tumorigenesis |
url | https://doi.org/10.1002/1878-0261.13308 |
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