A GENETIC STUDY OF PATIENTS WITH CHRONIC VENOUS INSUFFICIENCY BASED ON CLINICAL AND GENEALOGICAL METHOD
Relevance. Practically 10-15 % of the world's population has varicose veins as a manifestation of chronic venous insufficiency. The clinical and genealogical method is the method allows to identify family cases of disease in patients with chronic venous insufficiency. Objective: to demonstra...
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| Format: | Article |
| Language: | English |
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Bogomolets National Medical University
2018-06-01
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| Series: | Медична наука України |
| Subjects: | |
| Online Access: | https://msu-journal.com/index.php/journal/article/view/11 |
| _version_ | 1811286508184797184 |
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| author | Kh.O. Korolova V.V. Teplyi |
| author_facet | Kh.O. Korolova V.V. Teplyi |
| author_sort | Kh.O. Korolova |
| collection | DOAJ |
| description | Relevance. Practically 10-15 % of the world's population has varicose veins as a manifestation of chronic venous insufficiency. The clinical and genealogical method is the method allows to identify family cases of disease in patients with chronic venous insufficiency.
Objective: to demonstrate the role of heredity in varicose disease, to analyze family cases of varicose disease, to determine the type of disease inheritance and to give a prediction of heredity for descendants, using the clinical and genealogical method.
Materials and methods. The study involved 72 patients, mostly women – 46 (63.9 %) persons, with different classes of varicose veins according to the CEAP classification. To determine the type of inheritance we used clinical and genealogical method of pedigrees’ study. The nature of the trait – hereditary or non-hereditary disease; type of the inheritance – autosomal-dominant, autosomal-recessive, sex-linked, were defined.
Results. The family nature of the varicose disease was revealed in 17 (23 %) of the 72 examined patients. The autosomal-dominant type of inheritance was determined. There is direct inheritance across generations.
Conclusions. We determined the family nature of the disease inheritance, with the autosomal-dominant type of inheritance with a high degree of gene expression. In these families there is a high risk of the birth of the children who will have chronic venous insufficiency. |
| first_indexed | 2024-04-13T03:01:16Z |
| format | Article |
| id | doaj.art-aff827a0695e4496b10d524caedde9da |
| institution | Directory Open Access Journal |
| issn | 2664-472X 2664-4738 |
| language | English |
| last_indexed | 2024-04-13T03:01:16Z |
| publishDate | 2018-06-01 |
| publisher | Bogomolets National Medical University |
| record_format | Article |
| series | Медична наука України |
| spelling | doaj.art-aff827a0695e4496b10d524caedde9da2022-12-22T03:05:26ZengBogomolets National Medical UniversityМедична наука України2664-472X2664-47382018-06-01141-2596310.32345/2664-4738.1-2.2018.0911A GENETIC STUDY OF PATIENTS WITH CHRONIC VENOUS INSUFFICIENCY BASED ON CLINICAL AND GENEALOGICAL METHODKh.O. Korolova0V.V. Teplyi1O.O. Bogomolets national medical university, Kyiv, UkraineO.O. Bogomolets national medical university, Kyiv, UkraineRelevance. Practically 10-15 % of the world's population has varicose veins as a manifestation of chronic venous insufficiency. The clinical and genealogical method is the method allows to identify family cases of disease in patients with chronic venous insufficiency. Objective: to demonstrate the role of heredity in varicose disease, to analyze family cases of varicose disease, to determine the type of disease inheritance and to give a prediction of heredity for descendants, using the clinical and genealogical method. Materials and methods. The study involved 72 patients, mostly women – 46 (63.9 %) persons, with different classes of varicose veins according to the CEAP classification. To determine the type of inheritance we used clinical and genealogical method of pedigrees’ study. The nature of the trait – hereditary or non-hereditary disease; type of the inheritance – autosomal-dominant, autosomal-recessive, sex-linked, were defined. Results. The family nature of the varicose disease was revealed in 17 (23 %) of the 72 examined patients. The autosomal-dominant type of inheritance was determined. There is direct inheritance across generations. Conclusions. We determined the family nature of the disease inheritance, with the autosomal-dominant type of inheritance with a high degree of gene expression. In these families there is a high risk of the birth of the children who will have chronic venous insufficiency.https://msu-journal.com/index.php/journal/article/view/11varicose disease, chronic venous insufficiency, reticular varicose veins, clinical and genealogical survey method |
| spellingShingle | Kh.O. Korolova V.V. Teplyi A GENETIC STUDY OF PATIENTS WITH CHRONIC VENOUS INSUFFICIENCY BASED ON CLINICAL AND GENEALOGICAL METHOD Медична наука України varicose disease, chronic venous insufficiency, reticular varicose veins, clinical and genealogical survey method |
| title | A GENETIC STUDY OF PATIENTS WITH CHRONIC VENOUS INSUFFICIENCY BASED ON CLINICAL AND GENEALOGICAL METHOD |
| title_full | A GENETIC STUDY OF PATIENTS WITH CHRONIC VENOUS INSUFFICIENCY BASED ON CLINICAL AND GENEALOGICAL METHOD |
| title_fullStr | A GENETIC STUDY OF PATIENTS WITH CHRONIC VENOUS INSUFFICIENCY BASED ON CLINICAL AND GENEALOGICAL METHOD |
| title_full_unstemmed | A GENETIC STUDY OF PATIENTS WITH CHRONIC VENOUS INSUFFICIENCY BASED ON CLINICAL AND GENEALOGICAL METHOD |
| title_short | A GENETIC STUDY OF PATIENTS WITH CHRONIC VENOUS INSUFFICIENCY BASED ON CLINICAL AND GENEALOGICAL METHOD |
| title_sort | genetic study of patients with chronic venous insufficiency based on clinical and genealogical method |
| topic | varicose disease, chronic venous insufficiency, reticular varicose veins, clinical and genealogical survey method |
| url | https://msu-journal.com/index.php/journal/article/view/11 |
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