F199E substitution reduced toxicity of Clostridium perfringens epsilon toxin by depriving the receptor binding capability

F199E substitution reduced toxicity of Clostridium perfringens epsilon toxin by depriving the receptor binding capability

Epsilon toxin (ETX), a potent toxin, is produced by types B and D strains of Clostridium perfringens, which could cause severe diseases in humans and domestic animals. Mutant rETXF199E was previously demonstrated to be a good vaccine candidate. However, the mechanism concerned remains unknown. To cl...

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Bibliographic Details
Main Authors: Jingjing Kang, Jie Gao, Wenwu Yao, Lin Kang, Shan Gao, Hao Yang, Bin Ji, Ping Li, Jing Liu, Jiahao Yao, Wenwen Xin, Baohua Zhao, Jinglin Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2017-07-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
clostridium perfringens
epsilon toxin (etx)
mutant
mechanism
cell-binding
pore-forming
Online Access:http://dx.doi.org/10.1080/21645515.2017.1303022

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