Correlation between CT imaging characteristics and pathological diagnosis for subcentimeter pulmonary nodules
Abstract Background Advances in chest computed tomography (CT) have resulted in more frequent detection of subcentimeter pulmonary nodules (SCPNs), some of which are non‐benign and may represent invasive lung cancer. The present study aimed to explore the correlation between pathological diagnosis a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-04-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.14363 |
| _version_ | 1818355971469082624 |
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| author | Benchuang Hu Wangang Ren Zhen Feng Meng Li Xiao Li Rui Han Zhongmin Peng |
| author_facet | Benchuang Hu Wangang Ren Zhen Feng Meng Li Xiao Li Rui Han Zhongmin Peng |
| author_sort | Benchuang Hu |
| collection | DOAJ |
| description | Abstract Background Advances in chest computed tomography (CT) have resulted in more frequent detection of subcentimeter pulmonary nodules (SCPNs), some of which are non‐benign and may represent invasive lung cancer. The present study aimed to explore the correlation between pathological diagnosis and the CT imaging manifestations of SCPNs. Methods This retrospective study included patients who underwent pulmonary resection for SCPNs at Shandong Provincial Hospital in China. Lesions were divided into five categories according to their morphological characteristics on CT: cotton ball, solid‐filled with spiculation, solid‐filled with smooth edges, mixed‐density ground‐glass, and vacuolar. We further analyzed lesion size, enhancement patterns, vascular aggregation, and SCPN traversing. Chi‐square tests, Fisher's exact tests, and Welch's one‐way analysis of variance were used to examine the correlation between CT imaging characteristics and pathological type. Results There were statistically significant differences in the morphological distributions of SCPNs with different pathological types, including benign lesions and malignant lesions at different stages (p < 0.01). The morphological distributions of the four subtypes of invasive lung adenocarcinoma also exhibited significant differences (p < 0.01). In addition, size and enhancement patterns differed significantly among different pathological types of SCPNs. Conclusion Different pathological types of SCPNs exhibit significant differences based on their morphological category, size, and enhancement pattern on CT imaging. These CT characteristics may assist in the qualitative diagnosis of SCPNs. |
| first_indexed | 2024-12-13T19:49:48Z |
| format | Article |
| id | doaj.art-aff8e0d3b1184c31b0b396145fa86205 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-12-13T19:49:48Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-aff8e0d3b1184c31b0b396145fa862052022-12-21T23:33:28ZengWileyThoracic Cancer1759-77061759-77142022-04-011371067107510.1111/1759-7714.14363Correlation between CT imaging characteristics and pathological diagnosis for subcentimeter pulmonary nodulesBenchuang Hu0Wangang Ren1Zhen Feng2Meng Li3Xiao Li4Rui Han5Zhongmin Peng6Department of Thoracic Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong Province ChinaDepartment of Thoracic Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong Province ChinaDepartment of Thoracic Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong Province ChinaDepartment of Thoracic Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong Province ChinaDepartment of Thoracic Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong Province ChinaDepartment of Thoracic Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong Province ChinaDepartment of Thoracic Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong Province ChinaAbstract Background Advances in chest computed tomography (CT) have resulted in more frequent detection of subcentimeter pulmonary nodules (SCPNs), some of which are non‐benign and may represent invasive lung cancer. The present study aimed to explore the correlation between pathological diagnosis and the CT imaging manifestations of SCPNs. Methods This retrospective study included patients who underwent pulmonary resection for SCPNs at Shandong Provincial Hospital in China. Lesions were divided into five categories according to their morphological characteristics on CT: cotton ball, solid‐filled with spiculation, solid‐filled with smooth edges, mixed‐density ground‐glass, and vacuolar. We further analyzed lesion size, enhancement patterns, vascular aggregation, and SCPN traversing. Chi‐square tests, Fisher's exact tests, and Welch's one‐way analysis of variance were used to examine the correlation between CT imaging characteristics and pathological type. Results There were statistically significant differences in the morphological distributions of SCPNs with different pathological types, including benign lesions and malignant lesions at different stages (p < 0.01). The morphological distributions of the four subtypes of invasive lung adenocarcinoma also exhibited significant differences (p < 0.01). In addition, size and enhancement patterns differed significantly among different pathological types of SCPNs. Conclusion Different pathological types of SCPNs exhibit significant differences based on their morphological category, size, and enhancement pattern on CT imaging. These CT characteristics may assist in the qualitative diagnosis of SCPNs.https://doi.org/10.1111/1759-7714.14363adenocarcinomacomputed tomography imaginghistopathologymorphologicalsubcentimeter pulmonary nodules (SCPNs) |
| spellingShingle | Benchuang Hu Wangang Ren Zhen Feng Meng Li Xiao Li Rui Han Zhongmin Peng Correlation between CT imaging characteristics and pathological diagnosis for subcentimeter pulmonary nodules Thoracic Cancer adenocarcinoma computed tomography imaging histopathology morphological subcentimeter pulmonary nodules (SCPNs) |
| title | Correlation between CT imaging characteristics and pathological diagnosis for subcentimeter pulmonary nodules |
| title_full | Correlation between CT imaging characteristics and pathological diagnosis for subcentimeter pulmonary nodules |
| title_fullStr | Correlation between CT imaging characteristics and pathological diagnosis for subcentimeter pulmonary nodules |
| title_full_unstemmed | Correlation between CT imaging characteristics and pathological diagnosis for subcentimeter pulmonary nodules |
| title_short | Correlation between CT imaging characteristics and pathological diagnosis for subcentimeter pulmonary nodules |
| title_sort | correlation between ct imaging characteristics and pathological diagnosis for subcentimeter pulmonary nodules |
| topic | adenocarcinoma computed tomography imaging histopathology morphological subcentimeter pulmonary nodules (SCPNs) |
| url | https://doi.org/10.1111/1759-7714.14363 |
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