A Case of Probable Neurosarcoidosis Presenting as Unilateral Ophthalmoplegia
Sarcoidosis is a multisystem disease of unknown etiology, characterized by the presence of noncaseating epithelioid granulomas and accumulation of T lymphocytes and mononuclear phagocytes, which damages the normal structure of tissues. Isolated form of neurosarcoidosis is very rare and difficult to...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2015-01-01
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| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | http://hrcak.srce.hr/file/219251 |
| _version_ | 1818210095202304000 |
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| author | Mirjana Jovićević Marija Žarkov Tamara Rabi Žikić Duško Kozić Sonja Rajić Dušica Simić Panić |
| author_facet | Mirjana Jovićević Marija Žarkov Tamara Rabi Žikić Duško Kozić Sonja Rajić Dušica Simić Panić |
| author_sort | Mirjana Jovićević |
| collection | DOAJ |
| description | Sarcoidosis is a multisystem disease of unknown etiology, characterized by the presence of noncaseating epithelioid granulomas and accumulation of T lymphocytes and mononuclear phagocytes, which damages the normal structure of tissues. Isolated form of neurosarcoidosis is very rare and difficult to diagnose and requires histologic confirmation of noncaseating granulomas in the nervous tissue. We report a case of a 55-year-old female who had probable isolated neurosarcoidosis based on magnetic resonance imaging findings of relapsing pachymeningitis with an inflammatory process in the apex of the right orbit and pseudotumor inflammation of the superior and lateral recti of the right eye. Diagnosis was further verified by positive response to dual corticosteroid and immunosuppressive therapy. Our case demonstrates the importance of considering isolated neurosarcoidosis as a potential underlying etiology of painful ophthalmoplegia, even without systemic manifestation of the disease. |
| first_indexed | 2024-12-12T05:11:09Z |
| format | Article |
| id | doaj.art-aff91c1307ea4be8a814834e9f9cd5b7 |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-12-12T05:11:09Z |
| publishDate | 2015-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-aff91c1307ea4be8a814834e9f9cd5b72022-12-22T00:36:54ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512015-01-0154.3.359361A Case of Probable Neurosarcoidosis Presenting as Unilateral OphthalmoplegiaMirjana Jovićević0Marija Žarkov1Tamara Rabi Žikić2Duško Kozić3Sonja Rajić4Dušica Simić Panić5Clinical Department of Neurology, Clinical Center of Vojvodina, Novi Sad, SerbiaClinical Department of Neurology, Clinical Center of Vojvodina, Novi Sad, SerbiaClinical Department of Neurology, Clinical Center of Vojvodina, Novi Sad, SerbiaDiagnostic Imaging Center, Oncology Institute of Vojvodina, SerbiaClinical Department of Neurology, Emergency Center, Clinical Center of Vojvodina, Novi Sad, SerbiaDepartment for Medical Rehabilitation, Clinical Center of Vojvodina; Novi Sad, Serbia; , Medical Faculty, University of Novi Sad, Novi Sad, SerbiaSarcoidosis is a multisystem disease of unknown etiology, characterized by the presence of noncaseating epithelioid granulomas and accumulation of T lymphocytes and mononuclear phagocytes, which damages the normal structure of tissues. Isolated form of neurosarcoidosis is very rare and difficult to diagnose and requires histologic confirmation of noncaseating granulomas in the nervous tissue. We report a case of a 55-year-old female who had probable isolated neurosarcoidosis based on magnetic resonance imaging findings of relapsing pachymeningitis with an inflammatory process in the apex of the right orbit and pseudotumor inflammation of the superior and lateral recti of the right eye. Diagnosis was further verified by positive response to dual corticosteroid and immunosuppressive therapy. Our case demonstrates the importance of considering isolated neurosarcoidosis as a potential underlying etiology of painful ophthalmoplegia, even without systemic manifestation of the disease.http://hrcak.srce.hr/file/219251Neurosarcoidosis – diagnosisOphthalmoplegiaMagnetic resonance imagingCentral nervous system diseasesCase reports |
| spellingShingle | Mirjana Jovićević Marija Žarkov Tamara Rabi Žikić Duško Kozić Sonja Rajić Dušica Simić Panić A Case of Probable Neurosarcoidosis Presenting as Unilateral Ophthalmoplegia Acta Clinica Croatica Neurosarcoidosis – diagnosis Ophthalmoplegia Magnetic resonance imaging Central nervous system diseases Case reports |
| title | A Case of Probable Neurosarcoidosis Presenting as Unilateral Ophthalmoplegia |
| title_full | A Case of Probable Neurosarcoidosis Presenting as Unilateral Ophthalmoplegia |
| title_fullStr | A Case of Probable Neurosarcoidosis Presenting as Unilateral Ophthalmoplegia |
| title_full_unstemmed | A Case of Probable Neurosarcoidosis Presenting as Unilateral Ophthalmoplegia |
| title_short | A Case of Probable Neurosarcoidosis Presenting as Unilateral Ophthalmoplegia |
| title_sort | case of probable neurosarcoidosis presenting as unilateral ophthalmoplegia |
| topic | Neurosarcoidosis – diagnosis Ophthalmoplegia Magnetic resonance imaging Central nervous system diseases Case reports |
| url | http://hrcak.srce.hr/file/219251 |
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