Clinical and demographic characteristics, and problems related to medication in patients with 50 or more years with recent diagnosis of HIV in Medellín, Colombia
Introduction: multimorbidity, polypharmacy, and problems related to medication are common both, in aging people with HIV and in those diagnosed in advanced ages. Objective: To describe the demographics, clinical characteristics, and pro-blems related to medication in patients ≥ 50 years old with n...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Spanish |
| Published: |
Universidad de Antioquia
2023-04-01
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| Series: | Iatreia |
| Subjects: | |
| Online Access: | https://revistas.udea.edu.co/index.php/iatreia/article/view/347323/20807796 |
| Summary: | Introduction: multimorbidity, polypharmacy, and problems related to medication are common both, in aging people with HIV and in those diagnosed in advanced ages.
Objective: To describe the demographics, clinical characteristics, and pro-blems related to medication in patients ≥ 50 years old with new diagnosis of HIV.
Methods: A descriptive transversal study. This study included patients ≥ 50-year-old, with new diagnosis of infection with HIV, who attended four HIV healthcare programs in the city of Medellín, Colombia, between January 2013 and December 2016.
Results: 493 patients were analyzed. 62.7% (n=309) were in WHO clinical stage 3. 49.5% (n=244) had at least one definitory condition of AIDS, with wasting syndrome (23.7%, n=117) and tuberculosis (16.8%, n=82) being the most frequent ones. At the time of diagnosis, the median of CD4 and viral load was 176 cells/mL (IQR 59-352) and 117,323 copies/mL (IQR 28,237-411,139), respectively. 59% (n=291) had non-infectious comorbidities, with the two most common being arterial hypertension (22.3%, n=110) and dyslipidemia (14.2%, n=70). 66.1% (n=326) of patients had problems related to medication, being the most frequent: drug interactions (61.1%, n=301), polypharmacy with ARV drugs (53.1%), potentially inappropriate medication (7.9%, n=39), and high anticholinergic risk (2.4%, n=12). Conclusion: at the time of diagnosis, HIV-positive older adults frequently have multimorbidity, polypharmacy, and drug interactions. The diagnosis of HIV in this population is very delayed and the presence of opportunistic infections is frequent. |
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| ISSN: | 0121-0793 2011-7965 |