Clinical and demographic characteristics, and problems related to medication in patients with 50 or more years with recent diagnosis of HIV in Medellín, Colombia
Introduction: multimorbidity, polypharmacy, and problems related to medication are common both, in aging people with HIV and in those diagnosed in advanced ages. Objective: To describe the demographics, clinical characteristics, and pro-blems related to medication in patients ≥ 50 years old with n...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Spanish |
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Universidad de Antioquia
2023-04-01
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| Series: | Iatreia |
| Subjects: | |
| Online Access: | https://revistas.udea.edu.co/index.php/iatreia/article/view/347323/20807796 |
| _version_ | 1797842589255204864 |
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| author | Julián Andrés Hoyos-Pulgarín Carlos Andrés Restrepo Juan Carlos Alzate-Ángel Diego Alberto Molina-Ramírez Faiver Ramírez-Briñez Juan Pablo García-Henao |
| author_facet | Julián Andrés Hoyos-Pulgarín Carlos Andrés Restrepo Juan Carlos Alzate-Ángel Diego Alberto Molina-Ramírez Faiver Ramírez-Briñez Juan Pablo García-Henao |
| author_sort | Julián Andrés Hoyos-Pulgarín |
| collection | DOAJ |
| description | Introduction: multimorbidity, polypharmacy, and problems related to medication are common both, in aging people with HIV and in those diagnosed in advanced ages.
Objective: To describe the demographics, clinical characteristics, and pro-blems related to medication in patients ≥ 50 years old with new diagnosis of HIV.
Methods: A descriptive transversal study. This study included patients ≥ 50-year-old, with new diagnosis of infection with HIV, who attended four HIV healthcare programs in the city of Medellín, Colombia, between January 2013 and December 2016.
Results: 493 patients were analyzed. 62.7% (n=309) were in WHO clinical stage 3. 49.5% (n=244) had at least one definitory condition of AIDS, with wasting syndrome (23.7%, n=117) and tuberculosis (16.8%, n=82) being the most frequent ones. At the time of diagnosis, the median of CD4 and viral load was 176 cells/mL (IQR 59-352) and 117,323 copies/mL (IQR 28,237-411,139), respectively. 59% (n=291) had non-infectious comorbidities, with the two most common being arterial hypertension (22.3%, n=110) and dyslipidemia (14.2%, n=70). 66.1% (n=326) of patients had problems related to medication, being the most frequent: drug interactions (61.1%, n=301), polypharmacy with ARV drugs (53.1%), potentially inappropriate medication (7.9%, n=39), and high anticholinergic risk (2.4%, n=12). Conclusion: at the time of diagnosis, HIV-positive older adults frequently have multimorbidity, polypharmacy, and drug interactions. The diagnosis of HIV in this population is very delayed and the presence of opportunistic infections is frequent. |
| first_indexed | 2024-04-09T16:50:27Z |
| format | Article |
| id | doaj.art-aff990016e484024a27410bbccd21ee0 |
| institution | Directory Open Access Journal |
| issn | 0121-0793 2011-7965 |
| language | Spanish |
| last_indexed | 2024-04-09T16:50:27Z |
| publishDate | 2023-04-01 |
| publisher | Universidad de Antioquia |
| record_format | Article |
| series | Iatreia |
| spelling | doaj.art-aff990016e484024a27410bbccd21ee02023-04-21T16:14:03ZspaUniversidad de AntioquiaIatreia0121-07932011-79652023-04-0136218619610.17533/udea.iatreia.168Clinical and demographic characteristics, and problems related to medication in patients with 50 or more years with recent diagnosis of HIV in Medellín, ColombiaJulián Andrés Hoyos-Pulgarín0https://orcid.org/0000-0002-2629-5316Carlos Andrés Restrepo1https://orcid.org/0000-0003-1302-643XJuan Carlos Alzate-Ángel2https://orcid.org/0000-0003-0319-0623Diego Alberto Molina-Ramírez3Faiver Ramírez-Briñez4https://orcid.org/0000-0001-6803-1186Juan Pablo García-Henao5https://orcid.org/0000-0001-5099-2149Universidad Pontificia Bolivariana, Medellín, AntioquiaUniversidad de Antioquia, Medellín, ColombiaUnidad de Investigación Clínica, Corporación para Investigaciones Biológicas (CIB)Universidad de Antioquia, Medellín, ColombiaUniversidad de Antioquia, Medellín, ColombiaUniversidad Tecnológica de PereiraIntroduction: multimorbidity, polypharmacy, and problems related to medication are common both, in aging people with HIV and in those diagnosed in advanced ages. Objective: To describe the demographics, clinical characteristics, and pro-blems related to medication in patients ≥ 50 years old with new diagnosis of HIV. Methods: A descriptive transversal study. This study included patients ≥ 50-year-old, with new diagnosis of infection with HIV, who attended four HIV healthcare programs in the city of Medellín, Colombia, between January 2013 and December 2016. Results: 493 patients were analyzed. 62.7% (n=309) were in WHO clinical stage 3. 49.5% (n=244) had at least one definitory condition of AIDS, with wasting syndrome (23.7%, n=117) and tuberculosis (16.8%, n=82) being the most frequent ones. At the time of diagnosis, the median of CD4 and viral load was 176 cells/mL (IQR 59-352) and 117,323 copies/mL (IQR 28,237-411,139), respectively. 59% (n=291) had non-infectious comorbidities, with the two most common being arterial hypertension (22.3%, n=110) and dyslipidemia (14.2%, n=70). 66.1% (n=326) of patients had problems related to medication, being the most frequent: drug interactions (61.1%, n=301), polypharmacy with ARV drugs (53.1%), potentially inappropriate medication (7.9%, n=39), and high anticholinergic risk (2.4%, n=12). Conclusion: at the time of diagnosis, HIV-positive older adults frequently have multimorbidity, polypharmacy, and drug interactions. The diagnosis of HIV in this population is very delayed and the presence of opportunistic infections is frequent.https://revistas.udea.edu.co/index.php/iatreia/article/view/347323/20807796drug interactionshiv infectionspolypharmacy |
| spellingShingle | Julián Andrés Hoyos-Pulgarín Carlos Andrés Restrepo Juan Carlos Alzate-Ángel Diego Alberto Molina-Ramírez Faiver Ramírez-Briñez Juan Pablo García-Henao Clinical and demographic characteristics, and problems related to medication in patients with 50 or more years with recent diagnosis of HIV in Medellín, Colombia Iatreia drug interactions hiv infections polypharmacy |
| title | Clinical and demographic characteristics, and problems related to medication in patients with 50 or more years with recent diagnosis of HIV in Medellín, Colombia |
| title_full | Clinical and demographic characteristics, and problems related to medication in patients with 50 or more years with recent diagnosis of HIV in Medellín, Colombia |
| title_fullStr | Clinical and demographic characteristics, and problems related to medication in patients with 50 or more years with recent diagnosis of HIV in Medellín, Colombia |
| title_full_unstemmed | Clinical and demographic characteristics, and problems related to medication in patients with 50 or more years with recent diagnosis of HIV in Medellín, Colombia |
| title_short | Clinical and demographic characteristics, and problems related to medication in patients with 50 or more years with recent diagnosis of HIV in Medellín, Colombia |
| title_sort | clinical and demographic characteristics and problems related to medication in patients with 50 or more years with recent diagnosis of hiv in medellin colombia |
| topic | drug interactions hiv infections polypharmacy |
| url | https://revistas.udea.edu.co/index.php/iatreia/article/view/347323/20807796 |
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