The morphofunctional evaluation of patients at risk of malnutrition receiving a leucine-enriched nutritional supplement
This real-world study evaluated the evolution of the morphofunctional assessment of patients at risk of malnutrition using a leucine-enriched hyperproteic oral nutritional supplementation (ONS). A prospective observational one-arm study was used for 65 patients at risk of malnutrition, comparing med...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623004966 |
| _version_ | 1827620836345905152 |
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| author | Juan J. López-Gómez Olatz Izaola-Jauregui David Primo-Martín Emilia Gómez-Hoyos Beatriz Torres-Torres Rebeca Jiménez-Sahagún Paloma Pérez-López Daniel A. De Luis-Román |
| author_facet | Juan J. López-Gómez Olatz Izaola-Jauregui David Primo-Martín Emilia Gómez-Hoyos Beatriz Torres-Torres Rebeca Jiménez-Sahagún Paloma Pérez-López Daniel A. De Luis-Román |
| author_sort | Juan J. López-Gómez |
| collection | DOAJ |
| description | This real-world study evaluated the evolution of the morphofunctional assessment of patients at risk of malnutrition using a leucine-enriched hyperproteic oral nutritional supplementation (ONS). A prospective observational one-arm study was used for 65 patients at risk of malnutrition, comparing medical nutrition therapy with an adapted diet and leucine-enriched ONS once or twice daily. All patients were studied at baseline and three months after intervention with a morphofunctional assessment. The age of patients was 57.99(17.97) years. Forty-three(66.2%) patients were women. A decrease in the percent of weight loss was observed after intervention (men: baseline = 6.38[8.64]%; 3 months = -1.48[4.42]%; p < 0.01; women: baseline = 9.42[10.13]; 3 months = -1.49[4.11]; p < 0.01). An improvement in the phase angle in patients who consumed ONS twice daily (baseline = 4.43[0.88]; 3 months = 4.64[0.69]; p = 0.01). There was an increase in rectus femoris area adjusted by BMI in those who consumed two ONSs per day (baseline = 0.23[0.06]; 3 months = 0.24[0.06]; p = 0.01). Medical Nutrition Therapy with diet and a leucine enriched ONS in community patients with disease-related malnutrition stopped the percent of weight loss. The patients who consumed ONS twice daily showed an improvement in phase angle and ultrasonographic parameters. |
| first_indexed | 2024-03-09T10:53:36Z |
| format | Article |
| id | doaj.art-affa77ca258040a286a9a83d7097aa2f |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-09T10:53:36Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-affa77ca258040a286a9a83d7097aa2f2023-12-01T05:01:13ZengElsevierJournal of Functional Foods1756-46462023-12-01111105896The morphofunctional evaluation of patients at risk of malnutrition receiving a leucine-enriched nutritional supplementJuan J. López-Gómez0Olatz Izaola-Jauregui1David Primo-Martín2Emilia Gómez-Hoyos3Beatriz Torres-Torres4Rebeca Jiménez-Sahagún5Paloma Pérez-López6Daniel A. De Luis-Román7Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valladolid, Spain; Centro de Investigación Endocrinología y Nutrición, Universidad de Valladolid, Spain; Corresponding author at: Avenida Ramón y Cajal, n 2, 47003 Valladolid, Spain.Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valladolid, Spain; Centro de Investigación Endocrinología y Nutrición, Universidad de Valladolid, SpainServicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valladolid, Spain; Centro de Investigación Endocrinología y Nutrición, Universidad de Valladolid, SpainServicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valladolid, Spain; Centro de Investigación Endocrinología y Nutrición, Universidad de Valladolid, SpainServicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valladolid, Spain; Centro de Investigación Endocrinología y Nutrición, Universidad de Valladolid, SpainServicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valladolid, Spain; Centro de Investigación Endocrinología y Nutrición, Universidad de Valladolid, SpainServicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valladolid, Spain; Centro de Investigación Endocrinología y Nutrición, Universidad de Valladolid, SpainServicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valladolid, Spain; Centro de Investigación Endocrinología y Nutrición, Universidad de Valladolid, SpainThis real-world study evaluated the evolution of the morphofunctional assessment of patients at risk of malnutrition using a leucine-enriched hyperproteic oral nutritional supplementation (ONS). A prospective observational one-arm study was used for 65 patients at risk of malnutrition, comparing medical nutrition therapy with an adapted diet and leucine-enriched ONS once or twice daily. All patients were studied at baseline and three months after intervention with a morphofunctional assessment. The age of patients was 57.99(17.97) years. Forty-three(66.2%) patients were women. A decrease in the percent of weight loss was observed after intervention (men: baseline = 6.38[8.64]%; 3 months = -1.48[4.42]%; p < 0.01; women: baseline = 9.42[10.13]; 3 months = -1.49[4.11]; p < 0.01). An improvement in the phase angle in patients who consumed ONS twice daily (baseline = 4.43[0.88]; 3 months = 4.64[0.69]; p = 0.01). There was an increase in rectus femoris area adjusted by BMI in those who consumed two ONSs per day (baseline = 0.23[0.06]; 3 months = 0.24[0.06]; p = 0.01). Medical Nutrition Therapy with diet and a leucine enriched ONS in community patients with disease-related malnutrition stopped the percent of weight loss. The patients who consumed ONS twice daily showed an improvement in phase angle and ultrasonographic parameters.http://www.sciencedirect.com/science/article/pii/S1756464623004966LeucineOral nutritional supplementDisease related malnutritionMorphofunctional assessmentSarcopenia |
| spellingShingle | Juan J. López-Gómez Olatz Izaola-Jauregui David Primo-Martín Emilia Gómez-Hoyos Beatriz Torres-Torres Rebeca Jiménez-Sahagún Paloma Pérez-López Daniel A. De Luis-Román The morphofunctional evaluation of patients at risk of malnutrition receiving a leucine-enriched nutritional supplement Journal of Functional Foods Leucine Oral nutritional supplement Disease related malnutrition Morphofunctional assessment Sarcopenia |
| title | The morphofunctional evaluation of patients at risk of malnutrition receiving a leucine-enriched nutritional supplement |
| title_full | The morphofunctional evaluation of patients at risk of malnutrition receiving a leucine-enriched nutritional supplement |
| title_fullStr | The morphofunctional evaluation of patients at risk of malnutrition receiving a leucine-enriched nutritional supplement |
| title_full_unstemmed | The morphofunctional evaluation of patients at risk of malnutrition receiving a leucine-enriched nutritional supplement |
| title_short | The morphofunctional evaluation of patients at risk of malnutrition receiving a leucine-enriched nutritional supplement |
| title_sort | morphofunctional evaluation of patients at risk of malnutrition receiving a leucine enriched nutritional supplement |
| topic | Leucine Oral nutritional supplement Disease related malnutrition Morphofunctional assessment Sarcopenia |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623004966 |
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