Role of Scaffold Protein Proline-, Glutamic Acid-, and Leucine-Rich Protein 1 (PELP1) in the Modulation of Adrenocortical Cancer Cell Growth

Role of Scaffold Protein Proline-, Glutamic Acid-, and Leucine-Rich Protein 1 (PELP1) in the Modulation of Adrenocortical Cancer Cell Growth

PELP1 acts as an estrogen receptor (ER) coactivator that exerts an essential role in the ER’s functions. ER coregulators have a critical role in the progression and response to hormonal treatment of estrogen-dependent tumors. We previously demonstrated that, in adrenocortical carcinoma (ACC), ERα is...

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Bibliographic Details
Main Authors: Arianna De Luca, Paola Avena, Rosa Sirianni, Adele Chimento, Francesco Fallo, Catia Pilon, Ivan Casaburi, Vincenzo Pezzi
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Cells
Subjects:
adrenocortical carcinoma (ACC)
proline glutamic acid and leucine rich protein 1 (PELP1)
estrogen receptor α (ERα)
insulin growth factor-1 receptor (IGF1R)
insulin-like growth factor II (IGF-II)
Online Access:https://www.mdpi.com/2073-4409/6/4/42

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https://www.mdpi.com/2073-4409/6/4/42

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