Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate

Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate

Alternative splicing (AS) creates proteomic diversity from a limited size genome by generating numerous transcripts from a single protein-coding gene. Tissue-specific regulators of AS are essential components of the gene regulatory network, required for normal cellular function, tissue patterning, a...

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Bibliographic Details
Main Authors: Dasan Mary Cibi, Masum M Mia, Shamini Guna Shekeran, Lim Sze Yun, Reddemma Sandireddy, Priyanka Gupta, Monalisa Hota, Lei Sun, Sujoy Ghosh, Manvendra K Singh
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
alternative splicing
neural crest
Rbfox2
cleft palate
TGF-β signaling
Tak1
Online Access:https://elifesciences.org/articles/45418

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