| Summary: | Background With rapid developments of single‐cell sequencing and multi/trans‐omics, clinical single‐cell biomedicine is a new and emergent discipline to integrate single‐cell molecular and clinical phenomes and uncover new disease‐specific diagnosis and therapy. Aims The journal of Clinical and Translational Medicine (CTM) launches the first CTM initiative of Clinical Single‐Cell Biomedicine (cscBioMed) to promote the discovery and development of single‐cell‐based biology and medicine, speed the translation from single‐cell biology into clinical application, and improve early diagnosis and therapy for human diseases. Materials & Methods The cscBioMed initiative is speeding translational processes from circulating single‐cell RNA sequencing (scRNA‐seq) into routine measures in clinical biochemistry of hematology, from spatial transcriptomics into single‐cell pathology, from single‐cell‐based biomarkers and targets into clinical diagnostics and target drugs. Conclusion With a clear goal, we expect that cscBioMed will benefit the human health by establishing a clinical single‐cell dynamic monitoring and early predicting system and by improving diagnosis and treatment.
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