Adaptogenic Ashwagandha root extract modulates inflammatory markers in feline stress management: a double-blind placebo-controlled clinical trial
This study aimed to evaluate the safety and efficacy of oral administration of Ashwagandha root extract (ARE) in cats subjected to different types of stress. A randomized, double-blind, placebo-controlled veterinary clinical trial was conducted with sixteen healthy pet cats. Each cat was randomly as...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Journal of Applied Animal Research |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/09712119.2024.2335921 |
| _version_ | 1826922966582034432 |
|---|---|
| author | Ashok Kumar Devarasetti Kala Kumar Bharani Amit Khurana Sunil Anand Rajesh Kollipaka Venkata Dharma Teja Saranu Donga Durga Veera Hanuman Vamsi Krishna Addanki Vinaya Sree Chetla Anil Kumar Banothu |
| author_facet | Ashok Kumar Devarasetti Kala Kumar Bharani Amit Khurana Sunil Anand Rajesh Kollipaka Venkata Dharma Teja Saranu Donga Durga Veera Hanuman Vamsi Krishna Addanki Vinaya Sree Chetla Anil Kumar Banothu |
| author_sort | Ashok Kumar Devarasetti |
| collection | DOAJ |
| description | This study aimed to evaluate the safety and efficacy of oral administration of Ashwagandha root extract (ARE) in cats subjected to different types of stress. A randomized, double-blind, placebo-controlled veterinary clinical trial was conducted with sixteen healthy pet cats. Each cat was randomly assigned to receive ARE (15 mg/kg body weight) or a placebo and were subjected to four types of stress over a period of one month. No detrimental changes were observed in ALP, ALT, AST, glucose, creatinine, and BUN levels on day 30 with ARE with all values within the physiological range. Additionally, in the ARE-treated group, the protein (p < 0.05) and albumin (p < 0.01) levels were increased significantly, indicating overall improved liver function. Post 30 days ARE treatment, significant modulation of malondialdehyde (MDA) (p < 0.001), superoxide dismutase (SOD) (p < 0.001), glutathione (GSH) (p < 0.01) and catalase (p < 0.001) levels were observed with ARE compared to placebo control group. After 30 days ARE treatment, serum cortisol levels significantly decreased (p < 0.001), indicating strong anti-stress effects. There was a significant decrease in cytokine levels (TNF-α, IFN-γ & IL-10), NFκB and Nrf-2 levels in ARE treated group indicating potent anti-inflammatory effects. Overall, these promising results demonstrate that ARE possesses adaptogenic and anti-inflammatory properties and is safe in felines. |
| first_indexed | 2024-04-24T11:05:48Z |
| format | Article |
| id | doaj.art-afff0f67157b445a84242591832b5ad1 |
| institution | Directory Open Access Journal |
| issn | 0971-2119 0974-1844 |
| language | English |
| last_indexed | 2025-02-17T14:18:27Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Applied Animal Research |
| spelling | doaj.art-afff0f67157b445a84242591832b5ad12024-12-23T17:55:42ZengTaylor & Francis GroupJournal of Applied Animal Research0971-21190974-18442024-12-0152110.1080/09712119.2024.2335921Adaptogenic Ashwagandha root extract modulates inflammatory markers in feline stress management: a double-blind placebo-controlled clinical trialAshok Kumar Devarasetti0Kala Kumar Bharani1Amit Khurana2Sunil Anand3Rajesh Kollipaka4Venkata Dharma Teja Saranu5Donga Durga Veera Hanuman6Vamsi Krishna Addanki7Vinaya Sree Chetla8Anil Kumar Banothu9Department of Veterinary Biochemistry, College of Veterinary Science (CVSc), Warangal, IndiaDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), Hyderabad, IndiaInstitute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH Aachen University Hospital, Aachen, GermanyDepartment of Veterinary Gynaecology & Obstetrics, College of Veterinary Science (CVSc), Warangal, IndiaCure Pet Clinic, Hanamkonda, IndiaVet Diagno, Warangal, IndiaDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), Hyderabad, IndiaDepartment of Biotechnology, Government of India, New Delhi, IndiaDepartment of Veterinary Physiology, College of Veterinary Science (CVSc), Hyderabad, IndiaDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), Hyderabad, IndiaThis study aimed to evaluate the safety and efficacy of oral administration of Ashwagandha root extract (ARE) in cats subjected to different types of stress. A randomized, double-blind, placebo-controlled veterinary clinical trial was conducted with sixteen healthy pet cats. Each cat was randomly assigned to receive ARE (15 mg/kg body weight) or a placebo and were subjected to four types of stress over a period of one month. No detrimental changes were observed in ALP, ALT, AST, glucose, creatinine, and BUN levels on day 30 with ARE with all values within the physiological range. Additionally, in the ARE-treated group, the protein (p < 0.05) and albumin (p < 0.01) levels were increased significantly, indicating overall improved liver function. Post 30 days ARE treatment, significant modulation of malondialdehyde (MDA) (p < 0.001), superoxide dismutase (SOD) (p < 0.001), glutathione (GSH) (p < 0.01) and catalase (p < 0.001) levels were observed with ARE compared to placebo control group. After 30 days ARE treatment, serum cortisol levels significantly decreased (p < 0.001), indicating strong anti-stress effects. There was a significant decrease in cytokine levels (TNF-α, IFN-γ & IL-10), NFκB and Nrf-2 levels in ARE treated group indicating potent anti-inflammatory effects. Overall, these promising results demonstrate that ARE possesses adaptogenic and anti-inflammatory properties and is safe in felines.https://www.tandfonline.com/doi/10.1080/09712119.2024.2335921Ashwagandhacortisolfeline stressinflammatory cytokinesWithania somnifera |
| spellingShingle | Ashok Kumar Devarasetti Kala Kumar Bharani Amit Khurana Sunil Anand Rajesh Kollipaka Venkata Dharma Teja Saranu Donga Durga Veera Hanuman Vamsi Krishna Addanki Vinaya Sree Chetla Anil Kumar Banothu Adaptogenic Ashwagandha root extract modulates inflammatory markers in feline stress management: a double-blind placebo-controlled clinical trial Journal of Applied Animal Research Ashwagandha cortisol feline stress inflammatory cytokines Withania somnifera |
| title | Adaptogenic Ashwagandha root extract modulates inflammatory markers in feline stress management: a double-blind placebo-controlled clinical trial |
| title_full | Adaptogenic Ashwagandha root extract modulates inflammatory markers in feline stress management: a double-blind placebo-controlled clinical trial |
| title_fullStr | Adaptogenic Ashwagandha root extract modulates inflammatory markers in feline stress management: a double-blind placebo-controlled clinical trial |
| title_full_unstemmed | Adaptogenic Ashwagandha root extract modulates inflammatory markers in feline stress management: a double-blind placebo-controlled clinical trial |
| title_short | Adaptogenic Ashwagandha root extract modulates inflammatory markers in feline stress management: a double-blind placebo-controlled clinical trial |
| title_sort | adaptogenic ashwagandha root extract modulates inflammatory markers in feline stress management a double blind placebo controlled clinical trial |
| topic | Ashwagandha cortisol feline stress inflammatory cytokines Withania somnifera |
| url | https://www.tandfonline.com/doi/10.1080/09712119.2024.2335921 |
| work_keys_str_mv | AT ashokkumardevarasetti adaptogenicashwagandharootextractmodulatesinflammatorymarkersinfelinestressmanagementadoubleblindplacebocontrolledclinicaltrial AT kalakumarbharani adaptogenicashwagandharootextractmodulatesinflammatorymarkersinfelinestressmanagementadoubleblindplacebocontrolledclinicaltrial AT amitkhurana adaptogenicashwagandharootextractmodulatesinflammatorymarkersinfelinestressmanagementadoubleblindplacebocontrolledclinicaltrial AT sunilanand adaptogenicashwagandharootextractmodulatesinflammatorymarkersinfelinestressmanagementadoubleblindplacebocontrolledclinicaltrial AT rajeshkollipaka adaptogenicashwagandharootextractmodulatesinflammatorymarkersinfelinestressmanagementadoubleblindplacebocontrolledclinicaltrial AT venkatadharmatejasaranu adaptogenicashwagandharootextractmodulatesinflammatorymarkersinfelinestressmanagementadoubleblindplacebocontrolledclinicaltrial AT dongadurgaveerahanuman adaptogenicashwagandharootextractmodulatesinflammatorymarkersinfelinestressmanagementadoubleblindplacebocontrolledclinicaltrial AT vamsikrishnaaddanki adaptogenicashwagandharootextractmodulatesinflammatorymarkersinfelinestressmanagementadoubleblindplacebocontrolledclinicaltrial AT vinayasreechetla adaptogenicashwagandharootextractmodulatesinflammatorymarkersinfelinestressmanagementadoubleblindplacebocontrolledclinicaltrial AT anilkumarbanothu adaptogenicashwagandharootextractmodulatesinflammatorymarkersinfelinestressmanagementadoubleblindplacebocontrolledclinicaltrial |