Regulation of Toxin Production in Clostridium perfringens
The Gram-positive anaerobic bacterium Clostridium perfringens is widely distributed in nature, especially in soil and the gastrointestinal tracts of humans and animals. C. perfringens causes gas gangrene and food poisoning, and it produces extracellular enzymes and toxins that are thought to act syn...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-07-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6651/8/7/207 |
| _version_ | 1818035316156530688 |
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| author | Kaori Ohtani Tohru Shimizu |
| author_facet | Kaori Ohtani Tohru Shimizu |
| author_sort | Kaori Ohtani |
| collection | DOAJ |
| description | The Gram-positive anaerobic bacterium Clostridium perfringens is widely distributed in nature, especially in soil and the gastrointestinal tracts of humans and animals. C. perfringens causes gas gangrene and food poisoning, and it produces extracellular enzymes and toxins that are thought to act synergistically and contribute to its pathogenesis. A complicated regulatory network of toxin genes has been reported that includes a two-component system for regulatory RNA and cell-cell communication. It is necessary to clarify the global regulatory system of these genes in order to understand and treat the virulence of C. perfringens. We summarize the existing knowledge about the regulatory mechanisms here. |
| first_indexed | 2024-12-10T06:53:07Z |
| format | Article |
| id | doaj.art-afffc1e657044ba2aeed5e20d400ccd3 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-12-10T06:53:07Z |
| publishDate | 2016-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-afffc1e657044ba2aeed5e20d400ccd32022-12-22T01:58:31ZengMDPI AGToxins2072-66512016-07-018720710.3390/toxins8070207toxins8070207Regulation of Toxin Production in Clostridium perfringensKaori Ohtani0Tohru Shimizu1Miyarisan Pharmaceutical Co., Ltd., 1-10-3, Kaminakazato, Kita-ku, Tokyo 114-0016, JapanDepartment of Bacteriology, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, JapanThe Gram-positive anaerobic bacterium Clostridium perfringens is widely distributed in nature, especially in soil and the gastrointestinal tracts of humans and animals. C. perfringens causes gas gangrene and food poisoning, and it produces extracellular enzymes and toxins that are thought to act synergistically and contribute to its pathogenesis. A complicated regulatory network of toxin genes has been reported that includes a two-component system for regulatory RNA and cell-cell communication. It is necessary to clarify the global regulatory system of these genes in order to understand and treat the virulence of C. perfringens. We summarize the existing knowledge about the regulatory mechanisms here.http://www.mdpi.com/2072-6651/8/7/207C. perfringensregulatory network |
| spellingShingle | Kaori Ohtani Tohru Shimizu Regulation of Toxin Production in Clostridium perfringens Toxins C. perfringens regulatory network |
| title | Regulation of Toxin Production in Clostridium perfringens |
| title_full | Regulation of Toxin Production in Clostridium perfringens |
| title_fullStr | Regulation of Toxin Production in Clostridium perfringens |
| title_full_unstemmed | Regulation of Toxin Production in Clostridium perfringens |
| title_short | Regulation of Toxin Production in Clostridium perfringens |
| title_sort | regulation of toxin production in clostridium perfringens |
| topic | C. perfringens regulatory network |
| url | http://www.mdpi.com/2072-6651/8/7/207 |
| work_keys_str_mv | AT kaoriohtani regulationoftoxinproductioninclostridiumperfringens AT tohrushimizu regulationoftoxinproductioninclostridiumperfringens |