Alveolar epithelial cells are competent producers of interstitial extracellular matrix with disease relevant plasticity in a human in vitro 3D model
Abstract Alveolar epithelial cells (AEC) have been implicated in pathological remodelling. We examined the capacity of AEC to produce extracellular matrix (ECM) and thereby directly contribute towards remodelling in chronic lung diseases. Cryopreserved type 2 AEC (AEC2) from healthy lungs and chroni...
Main Authors: | Oskar Rosmark, Måns Kadefors, Göran Dellgren, Christofer Karlsson, Anders Ericsson, Sandra Lindstedt, Johan Malmström, Oskar Hallgren, Anna-Karin Larsson-Callerfelt, Gunilla Westergren-Thorsson |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-05-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-35011-z |
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