How Vaccinations Changed the Outcome of COVID-19 Infections in Kidney Transplant Patients: Single-Center Experience
Kidney transplant recipients are a vulnerable population at risk of a life-threatening COVID-19 infection with an incidence of death four-times higher than in the general population. The availability of mRNA COVID-19 vaccines has dramatically changed the fate of this infection also within this fragi...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/7/990 |
| _version_ | 1797415202322382848 |
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| author | Mariarosaria Campise Carlo Maria Alfieri Matteo Benedetti Alessandro Perna Roberta Miglio Paolo Molinari Angela Cervesato Silvia Giuliani Maria Teresa Gandolfo Anna Regalia Donata Cresseri Laura Alagna Andrea Gori Giuseppe Castellano |
| author_facet | Mariarosaria Campise Carlo Maria Alfieri Matteo Benedetti Alessandro Perna Roberta Miglio Paolo Molinari Angela Cervesato Silvia Giuliani Maria Teresa Gandolfo Anna Regalia Donata Cresseri Laura Alagna Andrea Gori Giuseppe Castellano |
| author_sort | Mariarosaria Campise |
| collection | DOAJ |
| description | Kidney transplant recipients are a vulnerable population at risk of a life-threatening COVID-19 infection with an incidence of death four-times higher than in the general population. The availability of mRNA COVID-19 vaccines has dramatically changed the fate of this infection also within this fragile population. Transplanted patients have an impaired immunological response also to mRNA vaccines. In March 2021, however, we started a vaccination campaign. These preliminary results show that both the incidence of death and of hospitalization dropped from 13% to 2.4% and from 45% to 12.5% compared to the previous outbreaks reported by our group. In univariate analysis, two variables were associated with an increased risk of hospitalization: older age and dyspnea (<i>p</i> = 0.023, <i>p</i> < 0.0001, respectively). In multivariate analysis, dyspnea (<i>p</i> < 0.0001) and mycophenolate therapy (<i>p</i> = 0.003) were independently associated with the risk of hospitalization. The association was even stronger when the two variables were combined (<i>p</i> < 0.0001). Vaccinations did not reduce the incidence of COVID-19 infections among our transplanted patients, but provided certain protection that was associated with a significantly better outcome for this infection. |
| first_indexed | 2024-03-09T05:45:20Z |
| format | Article |
| id | doaj.art-b002750b382244f78bc5d165240b7f74 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T05:45:20Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-b002750b382244f78bc5d165240b7f742023-12-03T12:22:00ZengMDPI AGVaccines2076-393X2022-06-0110799010.3390/vaccines10070990How Vaccinations Changed the Outcome of COVID-19 Infections in Kidney Transplant Patients: Single-Center ExperienceMariarosaria Campise0Carlo Maria Alfieri1Matteo Benedetti2Alessandro Perna3Roberta Miglio4Paolo Molinari5Angela Cervesato6Silvia Giuliani7Maria Teresa Gandolfo8Anna Regalia9Donata Cresseri10Laura Alagna11Andrea Gori12Giuseppe Castellano13Department of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDivision of Nephrology, Department of Translational Medical Sciences, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyUO Nefrologia e Dialisi ASST Fatebenefratelli-Sacco, 20157 Milan, ItalyDepartment of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDivision of Nephrology, Department of Translational Medical Sciences, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyInfectious Diseases Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyInfectious Diseases Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyKidney transplant recipients are a vulnerable population at risk of a life-threatening COVID-19 infection with an incidence of death four-times higher than in the general population. The availability of mRNA COVID-19 vaccines has dramatically changed the fate of this infection also within this fragile population. Transplanted patients have an impaired immunological response also to mRNA vaccines. In March 2021, however, we started a vaccination campaign. These preliminary results show that both the incidence of death and of hospitalization dropped from 13% to 2.4% and from 45% to 12.5% compared to the previous outbreaks reported by our group. In univariate analysis, two variables were associated with an increased risk of hospitalization: older age and dyspnea (<i>p</i> = 0.023, <i>p</i> < 0.0001, respectively). In multivariate analysis, dyspnea (<i>p</i> < 0.0001) and mycophenolate therapy (<i>p</i> = 0.003) were independently associated with the risk of hospitalization. The association was even stronger when the two variables were combined (<i>p</i> < 0.0001). Vaccinations did not reduce the incidence of COVID-19 infections among our transplanted patients, but provided certain protection that was associated with a significantly better outcome for this infection.https://www.mdpi.com/2076-393X/10/7/990COVID-19 infectionCOVID vaccinationkidney transplantpublic health |
| spellingShingle | Mariarosaria Campise Carlo Maria Alfieri Matteo Benedetti Alessandro Perna Roberta Miglio Paolo Molinari Angela Cervesato Silvia Giuliani Maria Teresa Gandolfo Anna Regalia Donata Cresseri Laura Alagna Andrea Gori Giuseppe Castellano How Vaccinations Changed the Outcome of COVID-19 Infections in Kidney Transplant Patients: Single-Center Experience Vaccines COVID-19 infection COVID vaccination kidney transplant public health |
| title | How Vaccinations Changed the Outcome of COVID-19 Infections in Kidney Transplant Patients: Single-Center Experience |
| title_full | How Vaccinations Changed the Outcome of COVID-19 Infections in Kidney Transplant Patients: Single-Center Experience |
| title_fullStr | How Vaccinations Changed the Outcome of COVID-19 Infections in Kidney Transplant Patients: Single-Center Experience |
| title_full_unstemmed | How Vaccinations Changed the Outcome of COVID-19 Infections in Kidney Transplant Patients: Single-Center Experience |
| title_short | How Vaccinations Changed the Outcome of COVID-19 Infections in Kidney Transplant Patients: Single-Center Experience |
| title_sort | how vaccinations changed the outcome of covid 19 infections in kidney transplant patients single center experience |
| topic | COVID-19 infection COVID vaccination kidney transplant public health |
| url | https://www.mdpi.com/2076-393X/10/7/990 |
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