Modulation of Crystallinity through Radiofrequency Electromagnetic Fields in PLLA/Magnetic Nanoparticles Composites: A Proof of Concept
To modulate the properties of degradable implants from outside of the human body represents a major challenge in the field of biomaterials. Polylactic acid is one of the most used polymers in biomedical applications, but it tends to lose its mechanical properties too quickly during degradation. In t...
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2021-07-01
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| Online Access: | https://www.mdpi.com/1996-1944/14/15/4300 |
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| author | Marta Multigner Irene Morales Marta Muñoz Victoria Bonache Fernando Giacomone Patricia de la Presa Rosario Benavente Belén Torres Diego Mantovani Joaquín Rams |
| author_facet | Marta Multigner Irene Morales Marta Muñoz Victoria Bonache Fernando Giacomone Patricia de la Presa Rosario Benavente Belén Torres Diego Mantovani Joaquín Rams |
| author_sort | Marta Multigner |
| collection | DOAJ |
| description | To modulate the properties of degradable implants from outside of the human body represents a major challenge in the field of biomaterials. Polylactic acid is one of the most used polymers in biomedical applications, but it tends to lose its mechanical properties too quickly during degradation. In the present study, a way to reinforce poly-L lactic acid (PLLA) with magnetic nanoparticles (MNPs) that have the capacity to heat under radiofrequency electromagnetic fields (EMF) is proposed. As mechanical and degradation properties are related to the crystallinity of PLLA, the aim of the work was to explore the possibility of modifying the structure of the polymer through the heating of the reinforcing MNPs by EMF within the biological limit range <i>f</i>·<i>H</i> < 5·× 10<sup>9</sup> Am<sup>−1</sup>·s<sup>−1</sup>. Composites were prepared by dispersing MNPs under sonication in a solution of PLLA. The heat released by the MNPs was monitored by an infrared camera and changes in the polymer were analyzed with differential scanning calorimetry and nanoindentation techniques. The crystallinity, hardness, and elastic modulus of nanocomposites increase with EMF treatment. |
| first_indexed | 2024-03-10T09:12:21Z |
| format | Article |
| id | doaj.art-b00366e8eeb547f686a4585ab4037b46 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T09:12:21Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-b00366e8eeb547f686a4585ab4037b462023-11-22T05:54:44ZengMDPI AGMaterials1996-19442021-07-011415430010.3390/ma14154300Modulation of Crystallinity through Radiofrequency Electromagnetic Fields in PLLA/Magnetic Nanoparticles Composites: A Proof of ConceptMarta Multigner0Irene Morales1Marta Muñoz2Victoria Bonache3Fernando Giacomone4Patricia de la Presa5Rosario Benavente6Belén Torres7Diego Mantovani8Joaquín Rams9Department of Applied Mathematics, Materials Science and Engineering and Electronic Technology, Universidad Rey Juan Carlos, 28933 Madrid, SpainInstituto de Magnetismo Aplicado, UCM-ADIF-CSIC, A6 22,500 Km, 28230 Las Rozas, SpainDepartment of Applied Mathematics, Materials Science and Engineering and Electronic Technology, Universidad Rey Juan Carlos, 28933 Madrid, SpainDepartment of Applied Mathematics, Materials Science and Engineering and Electronic Technology, Universidad Rey Juan Carlos, 28933 Madrid, SpainInstituto de Magnetismo Aplicado, UCM-ADIF-CSIC, A6 22,500 Km, 28230 Las Rozas, SpainInstituto de Magnetismo Aplicado, UCM-ADIF-CSIC, A6 22,500 Km, 28230 Las Rozas, SpainInstitute of Polymer Science and Technology (ICTP-CSIC), C/Juan de la Cierva 3, 28006 Madrid, SpainDepartment of Applied Mathematics, Materials Science and Engineering and Electronic Technology, Universidad Rey Juan Carlos, 28933 Madrid, SpainLaboratory for Biomaterials & Bioengineering (CRC-I), Department Min-Met-Materials Engineering & Research Center CHU de Québec, Laval University, Québec, QC G1V 0A6, CanadaDepartment of Applied Mathematics, Materials Science and Engineering and Electronic Technology, Universidad Rey Juan Carlos, 28933 Madrid, SpainTo modulate the properties of degradable implants from outside of the human body represents a major challenge in the field of biomaterials. Polylactic acid is one of the most used polymers in biomedical applications, but it tends to lose its mechanical properties too quickly during degradation. In the present study, a way to reinforce poly-L lactic acid (PLLA) with magnetic nanoparticles (MNPs) that have the capacity to heat under radiofrequency electromagnetic fields (EMF) is proposed. As mechanical and degradation properties are related to the crystallinity of PLLA, the aim of the work was to explore the possibility of modifying the structure of the polymer through the heating of the reinforcing MNPs by EMF within the biological limit range <i>f</i>·<i>H</i> < 5·× 10<sup>9</sup> Am<sup>−1</sup>·s<sup>−1</sup>. Composites were prepared by dispersing MNPs under sonication in a solution of PLLA. The heat released by the MNPs was monitored by an infrared camera and changes in the polymer were analyzed with differential scanning calorimetry and nanoindentation techniques. The crystallinity, hardness, and elastic modulus of nanocomposites increase with EMF treatment.https://www.mdpi.com/1996-1944/14/15/4300biodegradable nanocompositePLLAmagnetic nanoparticlesradiofrequency electromagnetic field |
| spellingShingle | Marta Multigner Irene Morales Marta Muñoz Victoria Bonache Fernando Giacomone Patricia de la Presa Rosario Benavente Belén Torres Diego Mantovani Joaquín Rams Modulation of Crystallinity through Radiofrequency Electromagnetic Fields in PLLA/Magnetic Nanoparticles Composites: A Proof of Concept Materials biodegradable nanocomposite PLLA magnetic nanoparticles radiofrequency electromagnetic field |
| title | Modulation of Crystallinity through Radiofrequency Electromagnetic Fields in PLLA/Magnetic Nanoparticles Composites: A Proof of Concept |
| title_full | Modulation of Crystallinity through Radiofrequency Electromagnetic Fields in PLLA/Magnetic Nanoparticles Composites: A Proof of Concept |
| title_fullStr | Modulation of Crystallinity through Radiofrequency Electromagnetic Fields in PLLA/Magnetic Nanoparticles Composites: A Proof of Concept |
| title_full_unstemmed | Modulation of Crystallinity through Radiofrequency Electromagnetic Fields in PLLA/Magnetic Nanoparticles Composites: A Proof of Concept |
| title_short | Modulation of Crystallinity through Radiofrequency Electromagnetic Fields in PLLA/Magnetic Nanoparticles Composites: A Proof of Concept |
| title_sort | modulation of crystallinity through radiofrequency electromagnetic fields in plla magnetic nanoparticles composites a proof of concept |
| topic | biodegradable nanocomposite PLLA magnetic nanoparticles radiofrequency electromagnetic field |
| url | https://www.mdpi.com/1996-1944/14/15/4300 |
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