ARB Compared with non-ARB in Preventing Cardiac Events in High Risk Hypertensive Patients: An Evidence Based Case Report
Background: High risk hypertensive patients have an increased risk of developing cardiovascular complication. It is better to use a proven cardio protective drugs to reduce blood pressure in high risk hypertensive patients. Angiotensin II receptor Blocker (ARB) is one type of antihyper-tensive drugs...
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| Format: | Article |
| Language: | English |
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Indonesian Heart Association
2013-06-01
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| Series: | Majalah Kardiologi Indonesia |
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| Online Access: | http://ijconline.id/index.php/ijc/article/view/59 |
| _version_ | 1818217596688793600 |
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| author | Alvin Nursalim Yoga Yuniadi |
| author_facet | Alvin Nursalim Yoga Yuniadi |
| author_sort | Alvin Nursalim |
| collection | DOAJ |
| description | Background: High risk hypertensive patients have an increased risk of developing cardiovascular complication. It is better to use a proven cardio protective drugs to reduce blood pressure in high risk hypertensive patients. Angiotensin II receptor Blocker (ARB) is one type of antihyper-tensive drugs with cardioprotective effect for hypertensive patients without
other risk factor. Whether cardioprotective effect of ARB also apply for a more specific population such as high risk hypertensive patients need to be investigated.
Aim: To determine the efficacy of ARB compared to non-ARBs in preventing cardiac event in a more specific population, such as high risk hypertensive patients.
Methods: A search was conducted on PubMed and Cochrane. The selection of title and abstract was done using inclusion and exclusion criterias. Three original articles were found and used as the evidence tor the clinical question. The selected studies were critically appraised for validity, importance and applicability.
Result: According to Sawada et al, the blood pressure lowering effect was similar between valsartan and non-ARB groups. The cardiovascular events in valsartan group is lower compared to non-ARB groups (relative risk: 0.54, 95% confidence interval 0.4-0.7, p< 0.001). The administration of valsartan as compared to non-ARB, also reduce the occurence of angina pectoris (Relative risk: 0.52, 95% Confidence Interval 0.310.86, P=0.01058). Cohn JN et al showed that there was no significant differences in the candesartan group in terms of total death and primary endpoints. The only significant finding in this article was the lower rate of diabetes mellitus in the candesartan group.
Conclusion: Valsartan, as compared to non-ARB, reduce cardic event in high risk hypertensive patients. |
| first_indexed | 2024-12-12T07:10:23Z |
| format | Article |
| id | doaj.art-b003a42e1b754c1caad2d1d712f57c72 |
| institution | Directory Open Access Journal |
| issn | 0126-3773 2620-4762 |
| language | English |
| last_indexed | 2024-12-12T07:10:23Z |
| publishDate | 2013-06-01 |
| publisher | Indonesian Heart Association |
| record_format | Article |
| series | Majalah Kardiologi Indonesia |
| spelling | doaj.art-b003a42e1b754c1caad2d1d712f57c722022-12-22T00:33:38ZengIndonesian Heart AssociationMajalah Kardiologi Indonesia0126-37732620-47622013-06-0133210.30701/ijc.v33i2.59ARB Compared with non-ARB in Preventing Cardiac Events in High Risk Hypertensive Patients: An Evidence Based Case ReportAlvin Nursalim0Yoga Yuniadi1Faculty of Medicine University of IndonesiaDepartement of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, and National Cardiovascular Center Harapan Kita, JakartaBackground: High risk hypertensive patients have an increased risk of developing cardiovascular complication. It is better to use a proven cardio protective drugs to reduce blood pressure in high risk hypertensive patients. Angiotensin II receptor Blocker (ARB) is one type of antihyper-tensive drugs with cardioprotective effect for hypertensive patients without other risk factor. Whether cardioprotective effect of ARB also apply for a more specific population such as high risk hypertensive patients need to be investigated. Aim: To determine the efficacy of ARB compared to non-ARBs in preventing cardiac event in a more specific population, such as high risk hypertensive patients. Methods: A search was conducted on PubMed and Cochrane. The selection of title and abstract was done using inclusion and exclusion criterias. Three original articles were found and used as the evidence tor the clinical question. The selected studies were critically appraised for validity, importance and applicability. Result: According to Sawada et al, the blood pressure lowering effect was similar between valsartan and non-ARB groups. The cardiovascular events in valsartan group is lower compared to non-ARB groups (relative risk: 0.54, 95% confidence interval 0.4-0.7, p< 0.001). The administration of valsartan as compared to non-ARB, also reduce the occurence of angina pectoris (Relative risk: 0.52, 95% Confidence Interval 0.310.86, P=0.01058). Cohn JN et al showed that there was no significant differences in the candesartan group in terms of total death and primary endpoints. The only significant finding in this article was the lower rate of diabetes mellitus in the candesartan group. Conclusion: Valsartan, as compared to non-ARB, reduce cardic event in high risk hypertensive patients.http://ijconline.id/index.php/ijc/article/view/59Angiotensin II receptor blockervalsartanhigh risk hypertensioncardiovascular complication |
| spellingShingle | Alvin Nursalim Yoga Yuniadi ARB Compared with non-ARB in Preventing Cardiac Events in High Risk Hypertensive Patients: An Evidence Based Case Report Majalah Kardiologi Indonesia Angiotensin II receptor blocker valsartan high risk hypertension cardiovascular complication |
| title | ARB Compared with non-ARB in Preventing Cardiac Events in High Risk Hypertensive Patients: An Evidence Based Case Report |
| title_full | ARB Compared with non-ARB in Preventing Cardiac Events in High Risk Hypertensive Patients: An Evidence Based Case Report |
| title_fullStr | ARB Compared with non-ARB in Preventing Cardiac Events in High Risk Hypertensive Patients: An Evidence Based Case Report |
| title_full_unstemmed | ARB Compared with non-ARB in Preventing Cardiac Events in High Risk Hypertensive Patients: An Evidence Based Case Report |
| title_short | ARB Compared with non-ARB in Preventing Cardiac Events in High Risk Hypertensive Patients: An Evidence Based Case Report |
| title_sort | arb compared with non arb in preventing cardiac events in high risk hypertensive patients an evidence based case report |
| topic | Angiotensin II receptor blocker valsartan high risk hypertension cardiovascular complication |
| url | http://ijconline.id/index.php/ijc/article/view/59 |
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