Oxidation of Isodrimeninol with PCC Yields Drimane Derivatives with Activity against <i>Candida</i> Yeast by Inhibition of Lanosterol 14-Alpha Demethylase

Oxidation of Isodrimeninol with PCC Yields Drimane Derivatives with Activity against <i>Candida</i> Yeast by Inhibition of Lanosterol 14-Alpha Demethylase

<i>Candida</i> species cause an opportunistic yeast infection called Candidiasis, which is responsible for more than 50,000 deaths every year around the world. Effective treatments against candidiasis caused by non-albicans <i>Candida</i> species such as <i>C. glabrata,...

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Bibliographic Details
Main Authors: Victor Marin, Andres Iturra, Andres Opazo, Bernd Schmidt, Matthias Heydenreich, Leandro Ortiz, Verónica A. Jiménez, Cristian Paz
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Biomolecules
Subjects:
Isodrimeninol
PCC oxidation
<i>Candida</i> yeast
molecular docking
lanosterol 14-alpha demethylase
Online Access:https://www.mdpi.com/2218-273X/10/8/1101

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