Case report: Successful medical management of adrenocortical carcinoma with metastasis in a Maltese dog
IntroductionAdrenocortical carcinoma (ACC) with metastasis has a grave prognosis, and adrenalectomy is associated with a high perioperative mortality rate in dogs. A favorable outcome following trilostane treatment in patients with metastatic ACC confirmed by a decreased size of the adrenal tumor an...
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1142418/full |
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| author | Sin-Wook Park Keon Kim Ock-Kyu Kim Woong-Bin Ro Chang-Min Lee |
| author_facet | Sin-Wook Park Keon Kim Ock-Kyu Kim Woong-Bin Ro Chang-Min Lee |
| author_sort | Sin-Wook Park |
| collection | DOAJ |
| description | IntroductionAdrenocortical carcinoma (ACC) with metastasis has a grave prognosis, and adrenalectomy is associated with a high perioperative mortality rate in dogs. A favorable outcome following trilostane treatment in patients with metastatic ACC confirmed by a decreased size of the adrenal tumor and metastatic lesions has not been reported in dogs.Case descriptionA 12-year-old neutered male Maltese dog was diagnosed with a right adrenal tumor and a hepatic mass. Adrenal-dependent hyperadrenocorticism (ADH) was diagnosed based on clinical signs and an adrenocorticotropic hormone stimulation test (ACTHST). In addition, tests for plasma metanephrine and normetanephrine ruled out a pheochromocytoma. Based on cytology and computed tomography, unresectable metastatic ACC was confirmed. The dog was managed with trilostane due to the presence of distant metastasis. Medical management improved the clinical signs and post-ACTHST cortisol concentrations. One year after the first presentation, the clinical signs and ACTHST test showed a favorable outcome. In addition, computed tomography revealed a decreased size of the right adrenal tumor and resolution of the hepatic mass.ConclusionsTrilostane could be considered as a treatment option for unresectable metastatic ACC. A decrease in tumor size following treatment with trilostane has not been reported in dogs. This case report is the first to demonstrate a favorable outcome of metastatic ACC following trilostane mono therapy for >1 year. |
| first_indexed | 2024-03-12T23:39:01Z |
| format | Article |
| id | doaj.art-b005501ff0f341138ea226304825ffee |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-03-12T23:39:01Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-b005501ff0f341138ea226304825ffee2023-07-15T03:03:24ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-07-011010.3389/fvets.2023.11424181142418Case report: Successful medical management of adrenocortical carcinoma with metastasis in a Maltese dogSin-Wook Park0Keon Kim1Ock-Kyu Kim2Woong-Bin Ro3Chang-Min Lee4Department of Veterinary Internal Medicine, College of Veterinary Medicine and BK21 FOUR Program for Creative Veterinary Science Research Center, Chonnam National University, Gwangju, South KoreaDepartment of Veterinary Internal Medicine, College of Veterinary Medicine and BK21 FOUR Program for Creative Veterinary Science Research Center, Chonnam National University, Gwangju, South KoreaDepartment of Veterinary Internal Medicine, College of Veterinary Medicine and BK21 FOUR Program for Creative Veterinary Science Research Center, Chonnam National University, Gwangju, South KoreaCat Vet Animal Hospital, Seongnam-si, Gyeonggi-do, South KoreaDepartment of Veterinary Internal Medicine, College of Veterinary Medicine and BK21 FOUR Program for Creative Veterinary Science Research Center, Chonnam National University, Gwangju, South KoreaIntroductionAdrenocortical carcinoma (ACC) with metastasis has a grave prognosis, and adrenalectomy is associated with a high perioperative mortality rate in dogs. A favorable outcome following trilostane treatment in patients with metastatic ACC confirmed by a decreased size of the adrenal tumor and metastatic lesions has not been reported in dogs.Case descriptionA 12-year-old neutered male Maltese dog was diagnosed with a right adrenal tumor and a hepatic mass. Adrenal-dependent hyperadrenocorticism (ADH) was diagnosed based on clinical signs and an adrenocorticotropic hormone stimulation test (ACTHST). In addition, tests for plasma metanephrine and normetanephrine ruled out a pheochromocytoma. Based on cytology and computed tomography, unresectable metastatic ACC was confirmed. The dog was managed with trilostane due to the presence of distant metastasis. Medical management improved the clinical signs and post-ACTHST cortisol concentrations. One year after the first presentation, the clinical signs and ACTHST test showed a favorable outcome. In addition, computed tomography revealed a decreased size of the right adrenal tumor and resolution of the hepatic mass.ConclusionsTrilostane could be considered as a treatment option for unresectable metastatic ACC. A decrease in tumor size following treatment with trilostane has not been reported in dogs. This case report is the first to demonstrate a favorable outcome of metastatic ACC following trilostane mono therapy for >1 year.https://www.frontiersin.org/articles/10.3389/fvets.2023.1142418/fulladrenal-dependent hyperadrenocorticismcanineadrenal tumormetastasistrilostane |
| spellingShingle | Sin-Wook Park Keon Kim Ock-Kyu Kim Woong-Bin Ro Chang-Min Lee Case report: Successful medical management of adrenocortical carcinoma with metastasis in a Maltese dog Frontiers in Veterinary Science adrenal-dependent hyperadrenocorticism canine adrenal tumor metastasis trilostane |
| title | Case report: Successful medical management of adrenocortical carcinoma with metastasis in a Maltese dog |
| title_full | Case report: Successful medical management of adrenocortical carcinoma with metastasis in a Maltese dog |
| title_fullStr | Case report: Successful medical management of adrenocortical carcinoma with metastasis in a Maltese dog |
| title_full_unstemmed | Case report: Successful medical management of adrenocortical carcinoma with metastasis in a Maltese dog |
| title_short | Case report: Successful medical management of adrenocortical carcinoma with metastasis in a Maltese dog |
| title_sort | case report successful medical management of adrenocortical carcinoma with metastasis in a maltese dog |
| topic | adrenal-dependent hyperadrenocorticism canine adrenal tumor metastasis trilostane |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1142418/full |
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