Highly Diastereoselective Synthesis of Tetrahydroquinoline Derivatives via [4 + 2] Annulation of Ortho-Tosylaminophenyl-Substituted Para-Quinone Methides and Cyanoalkenes

Highly Diastereoselective Synthesis of Tetrahydroquinoline Derivatives via [4 + 2] Annulation of Ortho-Tosylaminophenyl-Substituted Para-Quinone Methides and Cyanoalkenes

As a privileged structural motif, tetrahydroquinoline skeletons widely exist in biologically active natural products and pharmaceuticals. In this protocol, a highly diastereoselective [4 + 2] annulation of ortho-tosylaminophenyl-substituted p-QMs and cyanoalkenes to construct tetrahydroquinoline der...

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Bibliographic Details
Main Authors:	Taiwei Dong, Peifeng Wei, Min Li, Feng Gao, Yuan Qin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-11-01
Series:	Frontiers in Chemistry
Subjects:	tetrahydroquinolines p-quinone methides multi-substituted alkenes Aza-Michael 1 6-conjugate addition
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2021.764866/full

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