Non-antibacterial methods for the prevention and treatment of recurrent lower urinary tract infections
Urinary tract infections are widespread throughout the world and occupy one of the leading places among infectious diseases. Antibacterial methods are the basis of modern treatment standards. At the same time, a widespread increase in antibiotic resistance of the main uropathogens is currently obser...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2021-10-01
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| Series: | Vestnik Urologii |
| Subjects: | |
| Online Access: | https://www.urovest.ru/jour/article/view/477 |
| _version_ | 1797272097039319040 |
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| author | N. D. Kubin O. V. Volkova D. D. Shkarupa |
| author_facet | N. D. Kubin O. V. Volkova D. D. Shkarupa |
| author_sort | N. D. Kubin |
| collection | DOAJ |
| description | Urinary tract infections are widespread throughout the world and occupy one of the leading places among infectious diseases. Antibacterial methods are the basis of modern treatment standards. At the same time, a widespread increase in antibiotic resistance of the main uropathogens is currently observed. In clinical practice, recurrent lower urinary tract infections are increasingly common. Following this, the main task of the doctor is to maximize the recurrence-free interval. Given the obvious negative collateral effect of long-term antibiotic prophylaxis, specialists are increasingly turning to alternative methods. Non-antibacterial preventive measures are aimed at key links in the pathogenesis of the disease, such as counteracting the penetration and adhesion of uropathogens, as well as stimulating the immune system of the macroorganism. The available physicians' toolkit includes pharmacological agents (d-mannose, methenamine hippurate, estrogens, non-steroidal anti-inflammatory drugs, probiotics, intravesical glycosaminoglycans, immunostimulants and vaccines), natural uroantiseptics (medicinal herbs and cranberry products), as well as behavioural therapy. The main advantages of non-antibacterial methods for the treatment and prevention of lower urinary tract infections are environmental friendliness. It is associated with the absence of a negative effect on the commensal flora, as well as a reduction in the risk of developing antibiotic resistance. The current guidelines provide very limited information on the application of this approach to treatment. Published studies indicate the high potential of non-antibacterial methods, some of which are comparable in effectiveness to standard therapy. However, the quality of studies and the lack of drug use standards do not allow including this approach in the existing guidelines. The need for new, high-quality clinical trials is evident. |
| first_indexed | 2024-03-07T14:23:31Z |
| format | Article |
| id | doaj.art-b006aa8f0d554ee9bc30eba380b560e8 |
| institution | Directory Open Access Journal |
| issn | 2308-6424 |
| language | Russian |
| last_indexed | 2024-03-07T14:23:31Z |
| publishDate | 2021-10-01 |
| publisher | State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation |
| record_format | Article |
| series | Vestnik Urologii |
| spelling | doaj.art-b006aa8f0d554ee9bc30eba380b560e82024-03-06T08:56:05ZrusState Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian FederationVestnik Urologii2308-64242021-10-01939210610.21886/2308-6424-2021-9-3-92-106333Non-antibacterial methods for the prevention and treatment of recurrent lower urinary tract infectionsN. D. Kubin0O. V. Volkova1D. D. Shkarupa2St. Petersburg State University – Pirogov Clinic of Advanced Medical TechnologiesSt. Petersburg State University – Pirogov Clinic of Advanced Medical TechnologiesSt. Petersburg State University – Pirogov Clinic of Advanced Medical TechnologiesUrinary tract infections are widespread throughout the world and occupy one of the leading places among infectious diseases. Antibacterial methods are the basis of modern treatment standards. At the same time, a widespread increase in antibiotic resistance of the main uropathogens is currently observed. In clinical practice, recurrent lower urinary tract infections are increasingly common. Following this, the main task of the doctor is to maximize the recurrence-free interval. Given the obvious negative collateral effect of long-term antibiotic prophylaxis, specialists are increasingly turning to alternative methods. Non-antibacterial preventive measures are aimed at key links in the pathogenesis of the disease, such as counteracting the penetration and adhesion of uropathogens, as well as stimulating the immune system of the macroorganism. The available physicians' toolkit includes pharmacological agents (d-mannose, methenamine hippurate, estrogens, non-steroidal anti-inflammatory drugs, probiotics, intravesical glycosaminoglycans, immunostimulants and vaccines), natural uroantiseptics (medicinal herbs and cranberry products), as well as behavioural therapy. The main advantages of non-antibacterial methods for the treatment and prevention of lower urinary tract infections are environmental friendliness. It is associated with the absence of a negative effect on the commensal flora, as well as a reduction in the risk of developing antibiotic resistance. The current guidelines provide very limited information on the application of this approach to treatment. Published studies indicate the high potential of non-antibacterial methods, some of which are comparable in effectiveness to standard therapy. However, the quality of studies and the lack of drug use standards do not allow including this approach in the existing guidelines. The need for new, high-quality clinical trials is evident.https://www.urovest.ru/jour/article/view/477lower urinary tract infectioncystitisnon-antibacterial treatmentd-mannoseestrogensnonsteroidal anti-inflammatory drugsprobioticsglycosaminoglycansimmunostimulantsherbal medicine |
| spellingShingle | N. D. Kubin O. V. Volkova D. D. Shkarupa Non-antibacterial methods for the prevention and treatment of recurrent lower urinary tract infections Vestnik Urologii lower urinary tract infection cystitis non-antibacterial treatment d-mannose estrogens nonsteroidal anti-inflammatory drugs probiotics glycosaminoglycans immunostimulants herbal medicine |
| title | Non-antibacterial methods for the prevention and treatment of recurrent lower urinary tract infections |
| title_full | Non-antibacterial methods for the prevention and treatment of recurrent lower urinary tract infections |
| title_fullStr | Non-antibacterial methods for the prevention and treatment of recurrent lower urinary tract infections |
| title_full_unstemmed | Non-antibacterial methods for the prevention and treatment of recurrent lower urinary tract infections |
| title_short | Non-antibacterial methods for the prevention and treatment of recurrent lower urinary tract infections |
| title_sort | non antibacterial methods for the prevention and treatment of recurrent lower urinary tract infections |
| topic | lower urinary tract infection cystitis non-antibacterial treatment d-mannose estrogens nonsteroidal anti-inflammatory drugs probiotics glycosaminoglycans immunostimulants herbal medicine |
| url | https://www.urovest.ru/jour/article/view/477 |
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