Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis
IntroductionDysbiosis characterises breast cancer through direct or indirect interference in a variety of biological pathways; therefore, specific microbial patterns and diversity may be a biomarker for the diagnosis and prognosis of breast cancer. However, there is still much to determine about the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1144021/full |
| _version_ | 1797868233883123712 |
|---|---|
| author | May Soe Thu May Soe Thu May Soe Thu Korn Chotirosniramit Tanawin Nopsopon Tanawin Nopsopon Tanawin Nopsopon Nattiya Hirankarn Krit Pongpirul Krit Pongpirul Krit Pongpirul Krit Pongpirul Krit Pongpirul |
| author_facet | May Soe Thu May Soe Thu May Soe Thu Korn Chotirosniramit Tanawin Nopsopon Tanawin Nopsopon Tanawin Nopsopon Nattiya Hirankarn Krit Pongpirul Krit Pongpirul Krit Pongpirul Krit Pongpirul Krit Pongpirul |
| author_sort | May Soe Thu |
| collection | DOAJ |
| description | IntroductionDysbiosis characterises breast cancer through direct or indirect interference in a variety of biological pathways; therefore, specific microbial patterns and diversity may be a biomarker for the diagnosis and prognosis of breast cancer. However, there is still much to determine about the complex interplay of the gut microbiome and breast cancer.ObjectiveThis study aims to evaluate microbial alteration in breast cancer patients compared with control subjects, to explore intestine microbial modification from a range of different breast cancer treatments, and to identify the impact of microbiome patterns on the same treatment-receiving breast cancer patients.MethodsA literature search was conducted using electronic databases such as PubMed, Embase, and the CENTRAL databases up to April 2021. The search was limited to adult women with breast cancer and the English language. The results were synthesised qualitatively and quantitatively using random-effects meta-analysis.ResultsA total of 33 articles from 32 studies were included in the review, representing 19 case-control, eight cohorts, and five nonrandomised intervention researches. The gut and breast bacterial species were elevated in the cases of breast tumours, a significant increase in Methylobacterium radiotolerans (p = 0.015), in compared with healthy breast tissue. Meta-analysis of different α-diversity indexes such as Shannon index (p = 0.0005), observed species (p = 0.006), and faint’s phylogenetic diversity (p < 0.00001) revealed the low intestinal microbial diversity in patients with breast cancer. The microbiota abundance pattern was identified in different sample types, detection methods, menopausal status, nationality, obesity, sleep quality, and several interventions using qualitative analysis.ConclusionsThis systematic review elucidates the complex network of the microbiome, breast cancer, and therapeutic options, with the objective of providing a link for stronger research studies and towards personalised medicine to improve their quality of life. |
| first_indexed | 2024-04-09T23:52:47Z |
| format | Article |
| id | doaj.art-b006c07e6513443d8b2aed8a425feddd |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-09T23:52:47Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b006c07e6513443d8b2aed8a425feddd2023-03-17T05:07:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-03-011310.3389/fonc.2023.11440211144021Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysisMay Soe Thu0May Soe Thu1May Soe Thu2Korn Chotirosniramit3Tanawin Nopsopon4Tanawin Nopsopon5Tanawin Nopsopon6Nattiya Hirankarn7Krit Pongpirul8Krit Pongpirul9Krit Pongpirul10Krit Pongpirul11Krit Pongpirul12Joint Chulalongkorn University - University of Liverpool Ph.D. Programme in Biomedical Sciences and Biotechnology, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCenter of Excellence in Immunology and Immune-Mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDepartment of Infection Biology and Microbiomes, Faculty of Health and Life Science, University of Liverpool, Liverpool, United KingdomSchool of Global Health, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandSchool of Global Health, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDepartment of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandBrigham and Women’s Hospital, Harvard Medical School, Harvard University, Boston, MA, United StatesCenter of Excellence in Immunology and Immune-Mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDepartment of Infection Biology and Microbiomes, Faculty of Health and Life Science, University of Liverpool, Liverpool, United KingdomSchool of Global Health, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDepartment of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United StatesClinical Research Center, Bumrungrad International Hospital, Bangkok, ThailandIntroductionDysbiosis characterises breast cancer through direct or indirect interference in a variety of biological pathways; therefore, specific microbial patterns and diversity may be a biomarker for the diagnosis and prognosis of breast cancer. However, there is still much to determine about the complex interplay of the gut microbiome and breast cancer.ObjectiveThis study aims to evaluate microbial alteration in breast cancer patients compared with control subjects, to explore intestine microbial modification from a range of different breast cancer treatments, and to identify the impact of microbiome patterns on the same treatment-receiving breast cancer patients.MethodsA literature search was conducted using electronic databases such as PubMed, Embase, and the CENTRAL databases up to April 2021. The search was limited to adult women with breast cancer and the English language. The results were synthesised qualitatively and quantitatively using random-effects meta-analysis.ResultsA total of 33 articles from 32 studies were included in the review, representing 19 case-control, eight cohorts, and five nonrandomised intervention researches. The gut and breast bacterial species were elevated in the cases of breast tumours, a significant increase in Methylobacterium radiotolerans (p = 0.015), in compared with healthy breast tissue. Meta-analysis of different α-diversity indexes such as Shannon index (p = 0.0005), observed species (p = 0.006), and faint’s phylogenetic diversity (p < 0.00001) revealed the low intestinal microbial diversity in patients with breast cancer. The microbiota abundance pattern was identified in different sample types, detection methods, menopausal status, nationality, obesity, sleep quality, and several interventions using qualitative analysis.ConclusionsThis systematic review elucidates the complex network of the microbiome, breast cancer, and therapeutic options, with the objective of providing a link for stronger research studies and towards personalised medicine to improve their quality of life.https://www.frontiersin.org/articles/10.3389/fonc.2023.1144021/fullbreast cancerdysbiosisgut microbiomemicrobial diversityestrogen |
| spellingShingle | May Soe Thu May Soe Thu May Soe Thu Korn Chotirosniramit Tanawin Nopsopon Tanawin Nopsopon Tanawin Nopsopon Nattiya Hirankarn Krit Pongpirul Krit Pongpirul Krit Pongpirul Krit Pongpirul Krit Pongpirul Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis Frontiers in Oncology breast cancer dysbiosis gut microbiome microbial diversity estrogen |
| title | Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis |
| title_full | Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis |
| title_fullStr | Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis |
| title_full_unstemmed | Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis |
| title_short | Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis |
| title_sort | human gut breast and oral microbiome in breast cancer a systematic review and meta analysis |
| topic | breast cancer dysbiosis gut microbiome microbial diversity estrogen |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1144021/full |
| work_keys_str_mv | AT maysoethu humangutbreastandoralmicrobiomeinbreastcancerasystematicreviewandmetaanalysis AT maysoethu humangutbreastandoralmicrobiomeinbreastcancerasystematicreviewandmetaanalysis AT maysoethu humangutbreastandoralmicrobiomeinbreastcancerasystematicreviewandmetaanalysis AT kornchotirosniramit humangutbreastandoralmicrobiomeinbreastcancerasystematicreviewandmetaanalysis AT tanawinnopsopon humangutbreastandoralmicrobiomeinbreastcancerasystematicreviewandmetaanalysis AT tanawinnopsopon humangutbreastandoralmicrobiomeinbreastcancerasystematicreviewandmetaanalysis AT tanawinnopsopon humangutbreastandoralmicrobiomeinbreastcancerasystematicreviewandmetaanalysis AT nattiyahirankarn humangutbreastandoralmicrobiomeinbreastcancerasystematicreviewandmetaanalysis AT kritpongpirul humangutbreastandoralmicrobiomeinbreastcancerasystematicreviewandmetaanalysis AT kritpongpirul humangutbreastandoralmicrobiomeinbreastcancerasystematicreviewandmetaanalysis AT kritpongpirul humangutbreastandoralmicrobiomeinbreastcancerasystematicreviewandmetaanalysis AT kritpongpirul humangutbreastandoralmicrobiomeinbreastcancerasystematicreviewandmetaanalysis AT kritpongpirul humangutbreastandoralmicrobiomeinbreastcancerasystematicreviewandmetaanalysis |