Evolving Insights Into the Biological Function and Clinical Significance of Long Noncoding RNA in Glioblastoma
Glioblastoma (GBM) is one of the most prevalent and aggressive cancers worldwide. The overall survival period of GBM patients is only 15 months even with standard combination therapy. The absence of validated biomarkers for early diagnosis mainly accounts for worse clinical outcomes of GBM patients....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.846864/full |
| _version_ | 1811299882423549952 |
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| author | Kun Liu Hong Chen Yuanyuan Wang Liping Jiang Liping Jiang Yi Li |
| author_facet | Kun Liu Hong Chen Yuanyuan Wang Liping Jiang Liping Jiang Yi Li |
| author_sort | Kun Liu |
| collection | DOAJ |
| description | Glioblastoma (GBM) is one of the most prevalent and aggressive cancers worldwide. The overall survival period of GBM patients is only 15 months even with standard combination therapy. The absence of validated biomarkers for early diagnosis mainly accounts for worse clinical outcomes of GBM patients. Thus, there is an urgent requirement to characterize more biomarkers for the early diagnosis of GBM patients. In addition, the detailed molecular basis during GBM pathogenesis and oncogenesis is not fully understood, highlighting that it is of great significance to elucidate the molecular mechanisms of GBM initiation and development. Recently, accumulated pieces of evidence have revealed the central roles of long noncoding RNAs (lncRNAs) in the tumorigenesis and progression of GBM by binding with DNA, RNA, or protein. Targeting those oncogenic lncRNAs in GBM may be promising to develop more effective therapeutics. Furthermore, a better understanding of the biological function and underlying molecular basis of dysregulated lncRNAs in GBM initiation and development will offer new insights into GBM early diagnosis and develop novel treatments for GBM patients. Herein, this review builds on previous studies to summarize the dysregulated lncRNAs in GBM and their unique biological functions during GBM tumorigenesis and progression. In addition, new insights and challenges of lncRNA-based diagnostic and therapeutic potentials for GBM patients were also introduced. |
| first_indexed | 2024-04-13T06:43:09Z |
| format | Article |
| id | doaj.art-b006ca0c18a04ba5b5987e45aa92ede8 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-13T06:43:09Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-b006ca0c18a04ba5b5987e45aa92ede82022-12-22T02:57:41ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-04-011010.3389/fcell.2022.846864846864Evolving Insights Into the Biological Function and Clinical Significance of Long Noncoding RNA in GlioblastomaKun Liu0Hong Chen1Yuanyuan Wang2Liping Jiang3Liping Jiang4Yi Li5Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDepartment of Oncology, 920th Hospital of Joint Logistics Support Force, Teaching Hospital of Kunming Medical University, Kunming, ChinaDepartment of Pathology, 920th Hospital of Joint Logistics Support Force, Teaching Hospital of Kunming Medical University, Kunming, ChinaKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, ChinaDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, United StatesDepartment of Oncology, 920th Hospital of Joint Logistics Support Force, Teaching Hospital of Kunming Medical University, Kunming, ChinaGlioblastoma (GBM) is one of the most prevalent and aggressive cancers worldwide. The overall survival period of GBM patients is only 15 months even with standard combination therapy. The absence of validated biomarkers for early diagnosis mainly accounts for worse clinical outcomes of GBM patients. Thus, there is an urgent requirement to characterize more biomarkers for the early diagnosis of GBM patients. In addition, the detailed molecular basis during GBM pathogenesis and oncogenesis is not fully understood, highlighting that it is of great significance to elucidate the molecular mechanisms of GBM initiation and development. Recently, accumulated pieces of evidence have revealed the central roles of long noncoding RNAs (lncRNAs) in the tumorigenesis and progression of GBM by binding with DNA, RNA, or protein. Targeting those oncogenic lncRNAs in GBM may be promising to develop more effective therapeutics. Furthermore, a better understanding of the biological function and underlying molecular basis of dysregulated lncRNAs in GBM initiation and development will offer new insights into GBM early diagnosis and develop novel treatments for GBM patients. Herein, this review builds on previous studies to summarize the dysregulated lncRNAs in GBM and their unique biological functions during GBM tumorigenesis and progression. In addition, new insights and challenges of lncRNA-based diagnostic and therapeutic potentials for GBM patients were also introduced.https://www.frontiersin.org/articles/10.3389/fcell.2022.846864/fulllncRNAglioblastomadiagnostic biomarkerprognostic biomarkertargeted therapy |
| spellingShingle | Kun Liu Hong Chen Yuanyuan Wang Liping Jiang Liping Jiang Yi Li Evolving Insights Into the Biological Function and Clinical Significance of Long Noncoding RNA in Glioblastoma Frontiers in Cell and Developmental Biology lncRNA glioblastoma diagnostic biomarker prognostic biomarker targeted therapy |
| title | Evolving Insights Into the Biological Function and Clinical Significance of Long Noncoding RNA in Glioblastoma |
| title_full | Evolving Insights Into the Biological Function and Clinical Significance of Long Noncoding RNA in Glioblastoma |
| title_fullStr | Evolving Insights Into the Biological Function and Clinical Significance of Long Noncoding RNA in Glioblastoma |
| title_full_unstemmed | Evolving Insights Into the Biological Function and Clinical Significance of Long Noncoding RNA in Glioblastoma |
| title_short | Evolving Insights Into the Biological Function and Clinical Significance of Long Noncoding RNA in Glioblastoma |
| title_sort | evolving insights into the biological function and clinical significance of long noncoding rna in glioblastoma |
| topic | lncRNA glioblastoma diagnostic biomarker prognostic biomarker targeted therapy |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.846864/full |
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