Neurotransplantation: the time has come?
Problems in curing disorders of the brain are caused by several characteristic features of the nervous tissue, such as postmitotic nature of neurons, their limited reparative potential, significant energy dependence, etc. Because of special vulnerability and extremely high specialization, neurons ar...
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2018-12-01
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| Series: | Анналы клинической и экспериментальной неврологии |
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| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/557/447 |
| _version_ | 1811244286398693376 |
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| author | Sergey N. Illarioshkin |
| author_facet | Sergey N. Illarioshkin |
| author_sort | Sergey N. Illarioshkin |
| collection | DOAJ |
| description | Problems in curing disorders of the brain are caused by several characteristic features of the nervous tissue, such as postmitotic nature of neurons, their limited reparative potential, significant energy dependence, etc. Because of special vulnerability and extremely high specialization, neurons are very sensitive to the action of any pathological factors, while existing possibilities of their trophic and metabolic support are scanty. Therefore, the creation of new reparative strategies, including substitutive cell technologies, is immediate task in neurology. Neurodegenerative disorders, Parkinsons disease (PD), Huntingtons disease and others, are an ideal model for elaborating such strategies. As main motor symptoms of PD are related to degeneration of the dopaminergic nigrostriatal pathway, treatment of these patients, theoretically, may be based on transplantation of dopamine-producing neurons into the striatum. In the paper, analyzed are the results of many-year experimental (on models of parkinsonism) and preliminary clinical trials of neurotransplantation with the use of fetal tissues (dopaminergic cells of the ventral midbrain) and dopaminergic neurons differentiated from embryonal stem cells and induced pluripotent. Newest scientific achievements in this field, improvement of cell protocols and successful resolving of a number of technical and medical problems allow saying that neurotransplantation becomes clinical reality just before our eyes. |
| first_indexed | 2024-04-12T14:22:14Z |
| format | Article |
| id | doaj.art-b0083f21ef6b46dc85dd4f5259c3a677 |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-04-12T14:22:14Z |
| publishDate | 2018-12-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-b0083f21ef6b46dc85dd4f5259c3a6772022-12-22T03:29:32ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332018-12-01125S162410.25692/ACEN.2018.5.2428Neurotransplantation: the time has come?Sergey N. Illarioshkin0Research Center of NeurologyProblems in curing disorders of the brain are caused by several characteristic features of the nervous tissue, such as postmitotic nature of neurons, their limited reparative potential, significant energy dependence, etc. Because of special vulnerability and extremely high specialization, neurons are very sensitive to the action of any pathological factors, while existing possibilities of their trophic and metabolic support are scanty. Therefore, the creation of new reparative strategies, including substitutive cell technologies, is immediate task in neurology. Neurodegenerative disorders, Parkinsons disease (PD), Huntingtons disease and others, are an ideal model for elaborating such strategies. As main motor symptoms of PD are related to degeneration of the dopaminergic nigrostriatal pathway, treatment of these patients, theoretically, may be based on transplantation of dopamine-producing neurons into the striatum. In the paper, analyzed are the results of many-year experimental (on models of parkinsonism) and preliminary clinical trials of neurotransplantation with the use of fetal tissues (dopaminergic cells of the ventral midbrain) and dopaminergic neurons differentiated from embryonal stem cells and induced pluripotent. Newest scientific achievements in this field, improvement of cell protocols and successful resolving of a number of technical and medical problems allow saying that neurotransplantation becomes clinical reality just before our eyes.https://annaly-nevrologii.com/journal/pathID/article/viewFile/557/447neurotransplantationdopaminergic neuronsfetal cellsinduced pluripotent stem cellsparkinson’s disease |
| spellingShingle | Sergey N. Illarioshkin Neurotransplantation: the time has come? Анналы клинической и экспериментальной неврологии neurotransplantation dopaminergic neurons fetal cells induced pluripotent stem cells parkinson’s disease |
| title | Neurotransplantation: the time has come? |
| title_full | Neurotransplantation: the time has come? |
| title_fullStr | Neurotransplantation: the time has come? |
| title_full_unstemmed | Neurotransplantation: the time has come? |
| title_short | Neurotransplantation: the time has come? |
| title_sort | neurotransplantation the time has come |
| topic | neurotransplantation dopaminergic neurons fetal cells induced pluripotent stem cells parkinson’s disease |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/557/447 |
| work_keys_str_mv | AT sergeynillarioshkin neurotransplantationthetimehascome |