A continuous protocol for the epoxidation of olefins, monocyclic terpenes, and Alpha Beta Unsaturated Carbonyl Synthons using eco-friendly Flow Reactor Conditions
Herein, we report a simple synthetic protocol for selective epoxidation of olefins, monocyclic terpenes, and chalcones using a continuous semi-batch process in good to excellent yields. Mainly, industrial semi-batch epoxidation is an extremely risky process that includes very high safety measures to...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Results in Engineering |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S259012302200322X |
| _version_ | 1798028221622517760 |
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| author | Chidambaram R. Ramaswamy Imam Kopparapu Amol Raykar Abhijeet Kulkarani Vijaya Sankar A V Siva Ayyanar Akula Nagarjuna Ravi Kumar Cheedarala |
| author_facet | Chidambaram R. Ramaswamy Imam Kopparapu Amol Raykar Abhijeet Kulkarani Vijaya Sankar A V Siva Ayyanar Akula Nagarjuna Ravi Kumar Cheedarala |
| author_sort | Chidambaram R. Ramaswamy |
| collection | DOAJ |
| description | Herein, we report a simple synthetic protocol for selective epoxidation of olefins, monocyclic terpenes, and chalcones using a continuous semi-batch process in good to excellent yields. Mainly, industrial semi-batch epoxidation is an extremely risky process that includes very high safety measures to avoid the accumulation of peroxide species in the reactor during the process, which leads to accidents. To avoid the same, we have established a constant flow reactor protocol for the epoxidation of fore mentioned key synthons using a cyanamide-potassium carbonate catalytic system which helps to reduce the accumulation of the peroxide species, and also yields moderate to high yields of the desired products. The developed methodology was successfully utilized for the epoxidation of a range of aliphatic to aromatic olefins to generate corresponding epoxides. All the products and their structures were examined using 1HNMR, and 13NMR spectroscopy. More importantly, this proposed protocol is recyclable and reproducible where in using similar research conditions. |
| first_indexed | 2024-04-11T19:04:24Z |
| format | Article |
| id | doaj.art-b008af5d497d491caca4af87edc30b25 |
| institution | Directory Open Access Journal |
| issn | 2590-1230 |
| language | English |
| last_indexed | 2024-04-11T19:04:24Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Engineering |
| spelling | doaj.art-b008af5d497d491caca4af87edc30b252022-12-22T04:07:50ZengElsevierResults in Engineering2590-12302022-12-0116100652A continuous protocol for the epoxidation of olefins, monocyclic terpenes, and Alpha Beta Unsaturated Carbonyl Synthons using eco-friendly Flow Reactor ConditionsChidambaram R. Ramaswamy0Imam Kopparapu1Amol Raykar2Abhijeet Kulkarani3Vijaya Sankar A V4Siva Ayyanar5Akula Nagarjuna6Ravi Kumar Cheedarala7Supramolecular and Organometallic Chemistry Laboratory (SOCL), Department of Inorganic Chemistry, School of Chemistry, Madurai Kamaraj University, Palkalai Nagar, Madurai, Tamilnadu, 625 021, IndiaDepartment of Science and Humanities, Chirst University, Bangalore, 560074, IndiaFlowRHEX®, Proburgeon Pvt Ltd, A2-301, Sri Swami Samarth Landmark, Phase 2, Narhe Pune, 411041, IndiaFlowRHEX®, Proburgeon Pvt Ltd, A2-301, Sri Swami Samarth Landmark, Phase 2, Narhe Pune, 411041, IndiaDepartment of Science and Humanities, Chirst University, Bangalore, 560074, IndiaSupramolecular and Organometallic Chemistry Laboratory (SOCL), Department of Inorganic Chemistry, School of Chemistry, Madurai Kamaraj University, Palkalai Nagar, Madurai, Tamilnadu, 625 021, IndiaDepartment of Chemistry, Jawaharlal Nehru Technological University(JNTU), Kukatpally, Hyderabad, 500 050, IndiaResearch Institute of Mechatronics, Mechanical Engineering, Changwon National University, Changwondaehak-ro, Ulchang-gu, Changwon-city, 51139, South Korea; Corresponding author.Herein, we report a simple synthetic protocol for selective epoxidation of olefins, monocyclic terpenes, and chalcones using a continuous semi-batch process in good to excellent yields. Mainly, industrial semi-batch epoxidation is an extremely risky process that includes very high safety measures to avoid the accumulation of peroxide species in the reactor during the process, which leads to accidents. To avoid the same, we have established a constant flow reactor protocol for the epoxidation of fore mentioned key synthons using a cyanamide-potassium carbonate catalytic system which helps to reduce the accumulation of the peroxide species, and also yields moderate to high yields of the desired products. The developed methodology was successfully utilized for the epoxidation of a range of aliphatic to aromatic olefins to generate corresponding epoxides. All the products and their structures were examined using 1HNMR, and 13NMR spectroscopy. More importantly, this proposed protocol is recyclable and reproducible where in using similar research conditions.http://www.sciencedirect.com/science/article/pii/S259012302200322XEpoxidationFlow chemistryPlate reactorEpoxy carbonylsOlefins |
| spellingShingle | Chidambaram R. Ramaswamy Imam Kopparapu Amol Raykar Abhijeet Kulkarani Vijaya Sankar A V Siva Ayyanar Akula Nagarjuna Ravi Kumar Cheedarala A continuous protocol for the epoxidation of olefins, monocyclic terpenes, and Alpha Beta Unsaturated Carbonyl Synthons using eco-friendly Flow Reactor Conditions Results in Engineering Epoxidation Flow chemistry Plate reactor Epoxy carbonyls Olefins |
| title | A continuous protocol for the epoxidation of olefins, monocyclic terpenes, and Alpha Beta Unsaturated Carbonyl Synthons using eco-friendly Flow Reactor Conditions |
| title_full | A continuous protocol for the epoxidation of olefins, monocyclic terpenes, and Alpha Beta Unsaturated Carbonyl Synthons using eco-friendly Flow Reactor Conditions |
| title_fullStr | A continuous protocol for the epoxidation of olefins, monocyclic terpenes, and Alpha Beta Unsaturated Carbonyl Synthons using eco-friendly Flow Reactor Conditions |
| title_full_unstemmed | A continuous protocol for the epoxidation of olefins, monocyclic terpenes, and Alpha Beta Unsaturated Carbonyl Synthons using eco-friendly Flow Reactor Conditions |
| title_short | A continuous protocol for the epoxidation of olefins, monocyclic terpenes, and Alpha Beta Unsaturated Carbonyl Synthons using eco-friendly Flow Reactor Conditions |
| title_sort | continuous protocol for the epoxidation of olefins monocyclic terpenes and alpha beta unsaturated carbonyl synthons using eco friendly flow reactor conditions |
| topic | Epoxidation Flow chemistry Plate reactor Epoxy carbonyls Olefins |
| url | http://www.sciencedirect.com/science/article/pii/S259012302200322X |
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