Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil
Abstract INTRODUCTION: Benznidazole is used for treating Chagas disease (CD). This cross-sectional study aimed to characterize the adverse drug reactions (ADRs) of benznidazole at a public hospital in Brazil’s Federal District. METHODS: Medical records were analyzed and ADRs were categorized by...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Medicina Tropical (SBMT)
2020-01-01
|
| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100622&tlng=en |
| _version_ | 1811245441602289664 |
|---|---|
| author | Maria Katarine Costa Lucas Gontijo Hilda Maria Benevides da Silva de Arruda Elza Ferreira Noronha Maria Inês de Toledo |
| author_facet | Maria Katarine Costa Lucas Gontijo Hilda Maria Benevides da Silva de Arruda Elza Ferreira Noronha Maria Inês de Toledo |
| author_sort | Maria Katarine Costa Lucas Gontijo |
| collection | DOAJ |
| description | Abstract INTRODUCTION: Benznidazole is used for treating Chagas disease (CD). This cross-sectional study aimed to characterize the adverse drug reactions (ADRs) of benznidazole at a public hospital in Brazil’s Federal District. METHODS: Medical records were analyzed and ADRs were categorized by type, intensity, seriousness, and causality. RESULTS: Of the 62 patients who started benznidazole treatment for CD, 41 (66%) presented with 105 ADRs; 23 (37%) discontinued the treatment. Most reactions were classified as probable (81%), severe (63%), serious (67%), and dose-dependent (56%). CONCLUSIONS: The high incidence of ADRs because of treatment withdrawal revealed the need for safer alternatives for CD treatment. |
| first_indexed | 2024-04-12T14:39:07Z |
| format | Article |
| id | doaj.art-b008dce33aa3473d957c8c8f7a2ddbca |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-12T14:39:07Z |
| publishDate | 2020-01-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-b008dce33aa3473d957c8c8f7a2ddbca2022-12-22T03:28:55ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492020-01-015310.1590/0037-8682-0150-2019Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, BrazilMaria Katarine Costa Lucas GontijoHilda Maria Benevides da Silva de ArrudaElza Ferreira NoronhaMaria Inês de Toledohttps://orcid.org/0000-0003-4507-7346Abstract INTRODUCTION: Benznidazole is used for treating Chagas disease (CD). This cross-sectional study aimed to characterize the adverse drug reactions (ADRs) of benznidazole at a public hospital in Brazil’s Federal District. METHODS: Medical records were analyzed and ADRs were categorized by type, intensity, seriousness, and causality. RESULTS: Of the 62 patients who started benznidazole treatment for CD, 41 (66%) presented with 105 ADRs; 23 (37%) discontinued the treatment. Most reactions were classified as probable (81%), severe (63%), serious (67%), and dose-dependent (56%). CONCLUSIONS: The high incidence of ADRs because of treatment withdrawal revealed the need for safer alternatives for CD treatment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100622&tlng=enChagas diseaseBenznidazoleDrug-related side effectsAdverse reactions |
| spellingShingle | Maria Katarine Costa Lucas Gontijo Hilda Maria Benevides da Silva de Arruda Elza Ferreira Noronha Maria Inês de Toledo Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil Revista da Sociedade Brasileira de Medicina Tropical Chagas disease Benznidazole Drug-related side effects Adverse reactions |
| title | Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil |
| title_full | Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil |
| title_fullStr | Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil |
| title_full_unstemmed | Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil |
| title_short | Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil |
| title_sort | characterization of adverse reactions to benznidazole in patients with chagas disease in the federal district brazil |
| topic | Chagas disease Benznidazole Drug-related side effects Adverse reactions |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100622&tlng=en |
| work_keys_str_mv | AT mariakatarinecostalucasgontijo characterizationofadversereactionstobenznidazoleinpatientswithchagasdiseaseinthefederaldistrictbrazil AT hildamariabenevidesdasilvadearruda characterizationofadversereactionstobenznidazoleinpatientswithchagasdiseaseinthefederaldistrictbrazil AT elzaferreiranoronha characterizationofadversereactionstobenznidazoleinpatientswithchagasdiseaseinthefederaldistrictbrazil AT mariainesdetoledo characterizationofadversereactionstobenznidazoleinpatientswithchagasdiseaseinthefederaldistrictbrazil |