Synchronous endometrial and ovarian cancer and its recurrent risk factors: Case series
Background: Synchronous endometrial and ovarian cancer (SEOC) is a relatively rare entity with indistinct clinical manifestation but have a better prognosis compared to metastatic malignancy of each organ. The aim of the study is to determine the prognosis and factors associated with recurrence of S...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Cancer Treatment and Research Communications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468294223000527 |
| _version_ | 1797732881806655488 |
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| author | Niloufar Hoorshad Saina Nassiri Shaparak Najibi Elham Feizabad Narges Zamani |
| author_facet | Niloufar Hoorshad Saina Nassiri Shaparak Najibi Elham Feizabad Narges Zamani |
| author_sort | Niloufar Hoorshad |
| collection | DOAJ |
| description | Background: Synchronous endometrial and ovarian cancer (SEOC) is a relatively rare entity with indistinct clinical manifestation but have a better prognosis compared to metastatic malignancy of each organ. The aim of the study is to determine the prognosis and factors associated with recurrence of SEOC. Methods: This case-series study was performed on 37 histologically confirmed SEOC, diagnosed and treated in our tertiary hospital from March 2009 to September 2021. Disease-free survival (DFS) and overall survival (OS) rates following indicated procedure were calculated using the Kaplan-Meier method. Univariate and multivariate Cox regression analysis were used to determine risk factors of recurrence. Results: The mean age of participants was 49.38 (age range: 26–78). The most common complaints and symptoms were abdominal pain (40.5%), followed by abnormal uterine bleeding (29.7%). Most common histological presentation was endometroid type for both ovarian (46%) and endometrial (97.3%) cancers. Over the mean follow-up period of 85.54 months, 11 patients developed recurrence without mortality. Non-endometrioid histology of ovarian cancer, higher grade and stage of ovarian cancer, and omentum invasion were significantly associated with worse DFS in unvariate analysis. Lymphovascular invasion was the sole predictor of DFS in multivariate analysis. Conclusion: While this study was not able to investigate the risk factors of overall survival associated with SEOC, the results of this study provides an overview of clinicopathological presentation of the disease and emphasizes the importance of lymphovascular invasion in determining prognosis and DFS in SEOC. |
| first_indexed | 2024-03-12T12:20:58Z |
| format | Article |
| id | doaj.art-b00b17337cba456087be259f3f4fac49 |
| institution | Directory Open Access Journal |
| issn | 2468-2942 |
| language | English |
| last_indexed | 2024-03-12T12:20:58Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Treatment and Research Communications |
| spelling | doaj.art-b00b17337cba456087be259f3f4fac492023-08-30T05:54:24ZengElsevierCancer Treatment and Research Communications2468-29422023-01-0136100731Synchronous endometrial and ovarian cancer and its recurrent risk factors: Case seriesNiloufar Hoorshad0Saina Nassiri1Shaparak Najibi2Elham Feizabad3Narges Zamani4Department of Obstetrics and Gynecology, Tehran University of Medical Sciences, Tehran, IranDepartment of Obstetrics and Gynecology, Tehran University of Medical Sciences, Tehran, IranDepartment of Obstetrics and Gynecology, Tehran University of Medical Sciences, Tehran, IranDepartment of Obstetrics and Gynecology, Yas Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Gynecology Oncology, Vali-e-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran; Corresponding author at: Vali-Asr Hospital, Imam Khomeini Hospital Complex (IKHC), Keshavarz Blvd., Tehran, Iran.Background: Synchronous endometrial and ovarian cancer (SEOC) is a relatively rare entity with indistinct clinical manifestation but have a better prognosis compared to metastatic malignancy of each organ. The aim of the study is to determine the prognosis and factors associated with recurrence of SEOC. Methods: This case-series study was performed on 37 histologically confirmed SEOC, diagnosed and treated in our tertiary hospital from March 2009 to September 2021. Disease-free survival (DFS) and overall survival (OS) rates following indicated procedure were calculated using the Kaplan-Meier method. Univariate and multivariate Cox regression analysis were used to determine risk factors of recurrence. Results: The mean age of participants was 49.38 (age range: 26–78). The most common complaints and symptoms were abdominal pain (40.5%), followed by abnormal uterine bleeding (29.7%). Most common histological presentation was endometroid type for both ovarian (46%) and endometrial (97.3%) cancers. Over the mean follow-up period of 85.54 months, 11 patients developed recurrence without mortality. Non-endometrioid histology of ovarian cancer, higher grade and stage of ovarian cancer, and omentum invasion were significantly associated with worse DFS in unvariate analysis. Lymphovascular invasion was the sole predictor of DFS in multivariate analysis. Conclusion: While this study was not able to investigate the risk factors of overall survival associated with SEOC, the results of this study provides an overview of clinicopathological presentation of the disease and emphasizes the importance of lymphovascular invasion in determining prognosis and DFS in SEOC.http://www.sciencedirect.com/science/article/pii/S2468294223000527CarcinomaOvarian epithelialEndometrial neoplasmsRisk factor |
| spellingShingle | Niloufar Hoorshad Saina Nassiri Shaparak Najibi Elham Feizabad Narges Zamani Synchronous endometrial and ovarian cancer and its recurrent risk factors: Case series Cancer Treatment and Research Communications Carcinoma Ovarian epithelial Endometrial neoplasms Risk factor |
| title | Synchronous endometrial and ovarian cancer and its recurrent risk factors: Case series |
| title_full | Synchronous endometrial and ovarian cancer and its recurrent risk factors: Case series |
| title_fullStr | Synchronous endometrial and ovarian cancer and its recurrent risk factors: Case series |
| title_full_unstemmed | Synchronous endometrial and ovarian cancer and its recurrent risk factors: Case series |
| title_short | Synchronous endometrial and ovarian cancer and its recurrent risk factors: Case series |
| title_sort | synchronous endometrial and ovarian cancer and its recurrent risk factors case series |
| topic | Carcinoma Ovarian epithelial Endometrial neoplasms Risk factor |
| url | http://www.sciencedirect.com/science/article/pii/S2468294223000527 |
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