Somatostatinoma of the Vater's papilla in a patient with von Recklinghausen's disease
Background. Somatostatinomas of the gastrointestinal tract secret hormone somatostatin which can cause "inhibitory syndrome" comprising diabetes mellitus, cholelithiasis and steatorrheic diarrhea. It is also secreted by the D cells of Langerhans's islands of the pancreas as well as en...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2007-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500703219C.pdf |
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| author | Čolović Radoje Micev Marjan Grubor Nikica Radak Vladimir |
| author_facet | Čolović Radoje Micev Marjan Grubor Nikica Radak Vladimir |
| author_sort | Čolović Radoje |
| collection | DOAJ |
| description | Background. Somatostatinomas of the gastrointestinal tract secret hormone somatostatin which can cause "inhibitory syndrome" comprising diabetes mellitus, cholelithiasis and steatorrheic diarrhea. It is also secreted by the D cells of Langerhans's islands of the pancreas as well as endocrine cells of the stomack, small bowel, salivary glands and parafollicular cells of the thiroid gland. Somatostatinomas of the digestive tract appear within the pancreas and duodenum. Patients suffering from von Recklinghausens's disease are paticularly prone to the somatostatinomas of the duodenum. Case report. In this paper we presented a 51-year old female patient with von Recklinghausen's disease in whom, during the investigation for obstructive jaundice, tumor of the Vater's papilla was found. The patient was submitted to Whipple's duodenopancreatectomy. Histology and immunohistochemistry discovered type B glandular carcinoid tumor with strong antisomatostatin and mild antigastrin immunoreactivity. The patient stayed symptom-free more than four years now. Conclusion. Patients with von Recklinghausen's disease should be examined for other tumors, particularly carcinoids of the duodenum and papilla, especially if the signs of cholestasis are present. |
| first_indexed | 2024-12-12T13:14:44Z |
| format | Article |
| id | doaj.art-b00b74f8406040acac45cb3ad78db540 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-12-12T13:14:44Z |
| publishDate | 2007-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-b00b74f8406040acac45cb3ad78db5402022-12-22T00:23:27ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502007-01-0164321922210.2298/VSP0703219CSomatostatinoma of the Vater's papilla in a patient with von Recklinghausen's diseaseČolović RadojeMicev MarjanGrubor NikicaRadak VladimirBackground. Somatostatinomas of the gastrointestinal tract secret hormone somatostatin which can cause "inhibitory syndrome" comprising diabetes mellitus, cholelithiasis and steatorrheic diarrhea. It is also secreted by the D cells of Langerhans's islands of the pancreas as well as endocrine cells of the stomack, small bowel, salivary glands and parafollicular cells of the thiroid gland. Somatostatinomas of the digestive tract appear within the pancreas and duodenum. Patients suffering from von Recklinghausens's disease are paticularly prone to the somatostatinomas of the duodenum. Case report. In this paper we presented a 51-year old female patient with von Recklinghausen's disease in whom, during the investigation for obstructive jaundice, tumor of the Vater's papilla was found. The patient was submitted to Whipple's duodenopancreatectomy. Histology and immunohistochemistry discovered type B glandular carcinoid tumor with strong antisomatostatin and mild antigastrin immunoreactivity. The patient stayed symptom-free more than four years now. Conclusion. Patients with von Recklinghausen's disease should be examined for other tumors, particularly carcinoids of the duodenum and papilla, especially if the signs of cholestasis are present.http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500703219C.pdfneurofibromatosiscarcinoid tumorduodenumampulla of vater |
| spellingShingle | Čolović Radoje Micev Marjan Grubor Nikica Radak Vladimir Somatostatinoma of the Vater's papilla in a patient with von Recklinghausen's disease Vojnosanitetski Pregled neurofibromatosis carcinoid tumor duodenum ampulla of vater |
| title | Somatostatinoma of the Vater's papilla in a patient with von Recklinghausen's disease |
| title_full | Somatostatinoma of the Vater's papilla in a patient with von Recklinghausen's disease |
| title_fullStr | Somatostatinoma of the Vater's papilla in a patient with von Recklinghausen's disease |
| title_full_unstemmed | Somatostatinoma of the Vater's papilla in a patient with von Recklinghausen's disease |
| title_short | Somatostatinoma of the Vater's papilla in a patient with von Recklinghausen's disease |
| title_sort | somatostatinoma of the vater s papilla in a patient with von recklinghausen s disease |
| topic | neurofibromatosis carcinoid tumor duodenum ampulla of vater |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500703219C.pdf |
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