Quantification and Improvement of the Dynamics of Human Serum Albumin and Glycated Human Serum Albumin with Astaxanthin/Astaxanthin-Metal Ion Complexes: Physico-Chemical and Computational Approaches

Quantification and Improvement of the Dynamics of Human Serum Albumin and Glycated Human Serum Albumin with Astaxanthin/Astaxanthin-Metal Ion Complexes: Physico-Chemical and Computational Approaches

Glycated human serum albumin (gHSA) undergoes conformational changes and unfolding events caused by free radicals. The glycation process results in a reduced ability of albumin to act as an endogenous scavenger and transporter protein in diabetes mellitus type 2 (T2DM) patients. Astaxanthin (ASX) in...

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Bibliographic Details
Main Authors: Syahputra Wibowo, Jessica Costa, Maria Camilla Baratto, Rebecca Pogni, Sri Widyarti, Akhmad Sabarudin, Koichi Matsuo, Sutiman Bambang Sumitro
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
antioxidants
astaxanthin
astaxanthin metal complexes
human serum albumin
glycated human serum albumin
diabetes mellitus type 2
Online Access:https://www.mdpi.com/1422-0067/23/9/4771

Internet

https://www.mdpi.com/1422-0067/23/9/4771

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