Pemphigus Vulgaris: Application of Occlusal Soft Splint with Topical Steroid in the Treatment
Pemphigus vulgaris (PV) is a rare autoimmune bullous dermatosis with a high mortality rate if untreated. It is characterized by the binding of IgG autoantibodies to desmogleins 3 (DSG 3), a transmembrane glycoprotein adhesion molecule present on desmosomes. This glycoprotein strengthens the intercel...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2011-01-01
|
| Series: | Journal of Indian Academy of Oral Medicine and Radiology |
| Subjects: | |
| Online Access: | http://www.jiaomr.in/article.asp?issn=0972-1363;year=2011;volume=23;issue=3;spage=263;epage=266;aulast=Reddy;type=0 |
| _version_ | 1811276597180760064 |
|---|---|
| author | G Vivekanandh Reddy G Ramlal K Jitendar Reddy K Swetha A Madhavi |
| author_facet | G Vivekanandh Reddy G Ramlal K Jitendar Reddy K Swetha A Madhavi |
| author_sort | G Vivekanandh Reddy |
| collection | DOAJ |
| description | Pemphigus vulgaris (PV) is a rare autoimmune bullous dermatosis with a high mortality rate if untreated. It is characterized by the binding of IgG autoantibodies to desmogleins 3 (DSG 3), a transmembrane glycoprotein adhesion molecule present on desmosomes. This glycoprotein strengthens the intercellular connection, and loss of this connection due to the antigen-antibody reaction weakens and finally breaks the connection between epithelial cells resulting in blisters and desquamation Patients with PV mainly involving the mucosa have antibodies directed against DSG 3, but patients with PV involving both the skin and mucosa will have antibodies against both DSG 3 and DSG 1. Most patients are initially misdiagnosed and improperly treated for many months or even years. Dental professionals must be sufficiently familiar with the clinical manifestations of PV to ensure early diagnosis and treatment, since this in turn determines the prognosis and course of the disease. |
| first_indexed | 2024-04-13T00:00:42Z |
| format | Article |
| id | doaj.art-b00e12040e5645b99fcba0e94cecca8c |
| institution | Directory Open Access Journal |
| issn | 0972-1363 0975-1572 |
| language | English |
| last_indexed | 2024-04-13T00:00:42Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Academy of Oral Medicine and Radiology |
| spelling | doaj.art-b00e12040e5645b99fcba0e94cecca8c2022-12-22T03:11:23ZengWolters Kluwer Medknow PublicationsJournal of Indian Academy of Oral Medicine and Radiology0972-13630975-15722011-01-0123326326610.5005/jp-journals-10011-1143Pemphigus Vulgaris: Application of Occlusal Soft Splint with Topical Steroid in the TreatmentG Vivekanandh ReddyG RamlalK Jitendar ReddyK SwethaA MadhaviPemphigus vulgaris (PV) is a rare autoimmune bullous dermatosis with a high mortality rate if untreated. It is characterized by the binding of IgG autoantibodies to desmogleins 3 (DSG 3), a transmembrane glycoprotein adhesion molecule present on desmosomes. This glycoprotein strengthens the intercellular connection, and loss of this connection due to the antigen-antibody reaction weakens and finally breaks the connection between epithelial cells resulting in blisters and desquamation Patients with PV mainly involving the mucosa have antibodies directed against DSG 3, but patients with PV involving both the skin and mucosa will have antibodies against both DSG 3 and DSG 1. Most patients are initially misdiagnosed and improperly treated for many months or even years. Dental professionals must be sufficiently familiar with the clinical manifestations of PV to ensure early diagnosis and treatment, since this in turn determines the prognosis and course of the disease.http://www.jiaomr.in/article.asp?issn=0972-1363;year=2011;volume=23;issue=3;spage=263;epage=266;aulast=Reddy;type=0PemphigusAutoimmuneDesmogleinDesmosome |
| spellingShingle | G Vivekanandh Reddy G Ramlal K Jitendar Reddy K Swetha A Madhavi Pemphigus Vulgaris: Application of Occlusal Soft Splint with Topical Steroid in the Treatment Journal of Indian Academy of Oral Medicine and Radiology Pemphigus Autoimmune Desmoglein Desmosome |
| title | Pemphigus Vulgaris: Application of Occlusal Soft Splint with Topical Steroid in the Treatment |
| title_full | Pemphigus Vulgaris: Application of Occlusal Soft Splint with Topical Steroid in the Treatment |
| title_fullStr | Pemphigus Vulgaris: Application of Occlusal Soft Splint with Topical Steroid in the Treatment |
| title_full_unstemmed | Pemphigus Vulgaris: Application of Occlusal Soft Splint with Topical Steroid in the Treatment |
| title_short | Pemphigus Vulgaris: Application of Occlusal Soft Splint with Topical Steroid in the Treatment |
| title_sort | pemphigus vulgaris application of occlusal soft splint with topical steroid in the treatment |
| topic | Pemphigus Autoimmune Desmoglein Desmosome |
| url | http://www.jiaomr.in/article.asp?issn=0972-1363;year=2011;volume=23;issue=3;spage=263;epage=266;aulast=Reddy;type=0 |
| work_keys_str_mv | AT gvivekanandhreddy pemphigusvulgarisapplicationofocclusalsoftsplintwithtopicalsteroidinthetreatment AT gramlal pemphigusvulgarisapplicationofocclusalsoftsplintwithtopicalsteroidinthetreatment AT kjitendarreddy pemphigusvulgarisapplicationofocclusalsoftsplintwithtopicalsteroidinthetreatment AT kswetha pemphigusvulgarisapplicationofocclusalsoftsplintwithtopicalsteroidinthetreatment AT amadhavi pemphigusvulgarisapplicationofocclusalsoftsplintwithtopicalsteroidinthetreatment |