ACTIVATION OF BLOOD T-CELLS IN HIV/HCV CO-INFECTED PATIENT
Expression of HLA-DR which is immune response activation marker on T-cells and their subpopulations (CD4+ and CD8+ lymphocytes) and number of CD4+/CD25+ cells with immune suppression properties in blood of HIV/HCV coinfected patients depending on HIV viral load, AIDS and receiving of antiretroviral...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Association of medical doctors Sanamed Novi Pazar
2013-01-01
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| Series: | Sanamed |
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| Online Access: | http://www.sanamed.rs/sanamed_pdf/sanamed_8_1/ACTIVATION_OF_BLOOD.pdf |
| _version_ | 1797281077125971968 |
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| author | Matsiyeuskaya Natallia V. Tsyrkunov Vladimir M. |
| author_facet | Matsiyeuskaya Natallia V. Tsyrkunov Vladimir M. |
| author_sort | Matsiyeuskaya Natallia V. |
| collection | DOAJ |
| description | Expression of HLA-DR which is immune response activation marker on T-cells and their subpopulations (CD4+ and CD8+ lymphocytes) and number of CD4+/CD25+ cells with immune suppression properties in blood of HIV/HCV coinfected patients depending on HIV viral load, AIDS and receiving of antiretroviral therapy were studied. It was detected that HLA-DR expression on T-cells was significantly higher in patients with detectable HIV viral load, AIDS, and in patients not receiving antiretroviral therapy. Antiretroviral therapy leads to significant reduction of immune system activation markers expression, though it doesn’t allow to reach the level of healthy individuals. Number of CD4+/CD25+ cells had inverse correlation with activated CD3+ and CD3+CD8+ lymphocytes and HIV viral load. |
| first_indexed | 2024-03-07T16:52:22Z |
| format | Article |
| id | doaj.art-b012031ff8044071a89945ef37e3be88 |
| institution | Directory Open Access Journal |
| issn | 1452-662X 2217-8171 |
| language | English |
| last_indexed | 2024-03-07T16:52:22Z |
| publishDate | 2013-01-01 |
| publisher | Association of medical doctors Sanamed Novi Pazar |
| record_format | Article |
| series | Sanamed |
| spelling | doaj.art-b012031ff8044071a89945ef37e3be882024-03-03T05:02:07ZengAssociation of medical doctors Sanamed Novi PazarSanamed1452-662X2217-81712013-01-01811118ACTIVATION OF BLOOD T-CELLS IN HIV/HCV CO-INFECTED PATIENTMatsiyeuskaya Natallia V.Tsyrkunov Vladimir M.Expression of HLA-DR which is immune response activation marker on T-cells and their subpopulations (CD4+ and CD8+ lymphocytes) and number of CD4+/CD25+ cells with immune suppression properties in blood of HIV/HCV coinfected patients depending on HIV viral load, AIDS and receiving of antiretroviral therapy were studied. It was detected that HLA-DR expression on T-cells was significantly higher in patients with detectable HIV viral load, AIDS, and in patients not receiving antiretroviral therapy. Antiretroviral therapy leads to significant reduction of immune system activation markers expression, though it doesn’t allow to reach the level of healthy individuals. Number of CD4+/CD25+ cells had inverse correlation with activated CD3+ and CD3+CD8+ lymphocytes and HIV viral load.http://www.sanamed.rs/sanamed_pdf/sanamed_8_1/ACTIVATION_OF_BLOOD.pdfHIVHCVimmunity activationHLA—DRCD4+/CD25+ T-cells. |
| spellingShingle | Matsiyeuskaya Natallia V. Tsyrkunov Vladimir M. ACTIVATION OF BLOOD T-CELLS IN HIV/HCV CO-INFECTED PATIENT Sanamed HIV HCV immunity activation HLA—DR CD4+/CD25+ T-cells. |
| title | ACTIVATION OF BLOOD T-CELLS IN HIV/HCV CO-INFECTED PATIENT |
| title_full | ACTIVATION OF BLOOD T-CELLS IN HIV/HCV CO-INFECTED PATIENT |
| title_fullStr | ACTIVATION OF BLOOD T-CELLS IN HIV/HCV CO-INFECTED PATIENT |
| title_full_unstemmed | ACTIVATION OF BLOOD T-CELLS IN HIV/HCV CO-INFECTED PATIENT |
| title_short | ACTIVATION OF BLOOD T-CELLS IN HIV/HCV CO-INFECTED PATIENT |
| title_sort | activation of blood t cells in hiv hcv co infected patient |
| topic | HIV HCV immunity activation HLA—DR CD4+/CD25+ T-cells. |
| url | http://www.sanamed.rs/sanamed_pdf/sanamed_8_1/ACTIVATION_OF_BLOOD.pdf |
| work_keys_str_mv | AT matsiyeuskayanatalliav activationofbloodtcellsinhivhcvcoinfectedpatient AT tsyrkunovvladimirm activationofbloodtcellsinhivhcvcoinfectedpatient |