Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model
Nootkatone is one of the major active ingredients of <i>Alpiniae oxyphyllae</i>, which has been used as both food and medicinal plants for the treatment of diarrhea, ulceration, and enuresis. In this study, we aimed to investigate whether nootkatone treatment ameliorated the progression...
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MDPI AG
2021-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/11/3921 |
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| author | Chang-Mu Chen Chen-Yu Lin Yao-Pang Chung Chia-Hung Liu Kuo-Tong Huang Siao-Syun Guan Cheng-Tien Wu Shing-Hwa Liu |
| author_facet | Chang-Mu Chen Chen-Yu Lin Yao-Pang Chung Chia-Hung Liu Kuo-Tong Huang Siao-Syun Guan Cheng-Tien Wu Shing-Hwa Liu |
| author_sort | Chang-Mu Chen |
| collection | DOAJ |
| description | Nootkatone is one of the major active ingredients of <i>Alpiniae oxyphyllae</i>, which has been used as both food and medicinal plants for the treatment of diarrhea, ulceration, and enuresis. In this study, we aimed to investigate whether nootkatone treatment ameliorated the progression of chronic kidney diseases (CKD) and clarified its underlying mechanisms in an obstructive nephropathy (unilateral ureteral obstructive; UUO) mouse model. Our results revealed that nootkatone treatment preventively decreased the pathological changes and significantly mitigated the collagen deposition as well as the protein expression of fibrotic markers. Nootkatone could also alleviate oxidative stress-induced injury, inflammatory cell infiltration, and renal cell apoptotic death in the kidneys of UUO mice. These results demonstrated for the first time that nootkatone protected against the progression of CKD in a UUO mouse model. It may serve as a potential therapeutic candidate for CKD intervention. |
| first_indexed | 2024-03-10T05:12:07Z |
| format | Article |
| id | doaj.art-b01338e07a1a4d99a261c3b9ea2c464c |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T05:12:07Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-b01338e07a1a4d99a261c3b9ea2c464c2023-11-23T00:47:56ZengMDPI AGNutrients2072-66432021-11-011311392110.3390/nu13113921Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse ModelChang-Mu Chen0Chen-Yu Lin1Yao-Pang Chung2Chia-Hung Liu3Kuo-Tong Huang4Siao-Syun Guan5Cheng-Tien Wu6Shing-Hwa Liu7Division of Neurosurgery, Department of Surgery, College of Medicine and Hospital, National Taiwan University, Taipei 10051, TaiwanInstitute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, TaiwanInstitute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, TaiwanDepartment of Urology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11041, TaiwanDepartment of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei 10051, TaiwanInstitute of Nuclear Energy Research, Atomic Energy Council, Taoyuan 32546, TaiwanDepartment of Nutrition, China Medical University, Taichung 406040, TaiwanInstitute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, TaiwanNootkatone is one of the major active ingredients of <i>Alpiniae oxyphyllae</i>, which has been used as both food and medicinal plants for the treatment of diarrhea, ulceration, and enuresis. In this study, we aimed to investigate whether nootkatone treatment ameliorated the progression of chronic kidney diseases (CKD) and clarified its underlying mechanisms in an obstructive nephropathy (unilateral ureteral obstructive; UUO) mouse model. Our results revealed that nootkatone treatment preventively decreased the pathological changes and significantly mitigated the collagen deposition as well as the protein expression of fibrotic markers. Nootkatone could also alleviate oxidative stress-induced injury, inflammatory cell infiltration, and renal cell apoptotic death in the kidneys of UUO mice. These results demonstrated for the first time that nootkatone protected against the progression of CKD in a UUO mouse model. It may serve as a potential therapeutic candidate for CKD intervention.https://www.mdpi.com/2072-6643/13/11/3921chronic kidney diseasenootkatoneinflammationapoptosisrenal fibrosis |
| spellingShingle | Chang-Mu Chen Chen-Yu Lin Yao-Pang Chung Chia-Hung Liu Kuo-Tong Huang Siao-Syun Guan Cheng-Tien Wu Shing-Hwa Liu Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model Nutrients chronic kidney disease nootkatone inflammation apoptosis renal fibrosis |
| title | Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model |
| title_full | Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model |
| title_fullStr | Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model |
| title_full_unstemmed | Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model |
| title_short | Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model |
| title_sort | protective effects of nootkatone on renal inflammation apoptosis and fibrosis in a unilateral ureteral obstructive mouse model |
| topic | chronic kidney disease nootkatone inflammation apoptosis renal fibrosis |
| url | https://www.mdpi.com/2072-6643/13/11/3921 |
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