Prognostic and clinicopathological role of geriatric nutritional risk index in patients with diffuse large B-cell lymphoma: A meta-analysis
BackgroundPrevious studies have explored the relationship between the geriatric nutritional risk index (GNRI) and survival outcomes of diffuse large B-cell lymphoma (DLBCL) cases, but the results were inconsistent. Consequently, the present meta-analysis was conducted to investigate how GNRI affects...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1169749/full |
| _version_ | 1797856299542642688 |
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| author | Dan Cao Zongxin Zhang |
| author_facet | Dan Cao Zongxin Zhang |
| author_sort | Dan Cao |
| collection | DOAJ |
| description | BackgroundPrevious studies have explored the relationship between the geriatric nutritional risk index (GNRI) and survival outcomes of diffuse large B-cell lymphoma (DLBCL) cases, but the results were inconsistent. Consequently, the present meta-analysis was conducted to investigate how GNRI affects DLBCL and its function in terms of prognosis.MethodsThe Web of Science, PubMed, Embase, and Cochrane Library databases were thoroughly searched until January 18, 2023. We calculated combined hazard ratios (HRs) and 95% confidence intervals (CIs) to estimate the relationship between the GNRI and survival outcomes of patients with DLBCL.ResultsThis meta-analysis included seven articles involving 2,353 cases. A lower level of GNRI predicted dismal overall survival (HR=1.40, 95% CI=1.25–1.56, p<0.001) and inferior progression-free survival (HR=1.46, 95% CI=1.19-1.80, p<0.001) of DLBCL patients. Moreover, a low GNRI was significantly related to Eastern Cooperative Oncology Group Performance Status ≥2 (odds ratio [OR]=4.55, 95% CI=2.75–7.54, p<0.001), Ann Arbor stage III–IV (OR=2.91, 95% CI=2.38–3.57, p<0.001), B symptoms (OR=3.51, 95% CI=2.34–5.29, p<0.001), and extranodal disease (OR=2.90, 95% CI=2.32–3.63, p<0.001).ConclusionA lower GNRI level predicted poorer short- and long-term prognosis in patients with DLBCL. A low GNRI was correlated with clinical factors of disease progression in DLBCL patients. |
| first_indexed | 2024-04-09T20:38:13Z |
| format | Article |
| id | doaj.art-b013f1db8ae74842af72fa5ed540462d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-09T20:38:13Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b013f1db8ae74842af72fa5ed540462d2023-03-30T06:36:37ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-03-011310.3389/fonc.2023.11697491169749Prognostic and clinicopathological role of geriatric nutritional risk index in patients with diffuse large B-cell lymphoma: A meta-analysisDan Cao0Zongxin Zhang1Department of Hematology, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, Zhejiang, ChinaClinical Laboratory, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, Zhejiang, ChinaBackgroundPrevious studies have explored the relationship between the geriatric nutritional risk index (GNRI) and survival outcomes of diffuse large B-cell lymphoma (DLBCL) cases, but the results were inconsistent. Consequently, the present meta-analysis was conducted to investigate how GNRI affects DLBCL and its function in terms of prognosis.MethodsThe Web of Science, PubMed, Embase, and Cochrane Library databases were thoroughly searched until January 18, 2023. We calculated combined hazard ratios (HRs) and 95% confidence intervals (CIs) to estimate the relationship between the GNRI and survival outcomes of patients with DLBCL.ResultsThis meta-analysis included seven articles involving 2,353 cases. A lower level of GNRI predicted dismal overall survival (HR=1.40, 95% CI=1.25–1.56, p<0.001) and inferior progression-free survival (HR=1.46, 95% CI=1.19-1.80, p<0.001) of DLBCL patients. Moreover, a low GNRI was significantly related to Eastern Cooperative Oncology Group Performance Status ≥2 (odds ratio [OR]=4.55, 95% CI=2.75–7.54, p<0.001), Ann Arbor stage III–IV (OR=2.91, 95% CI=2.38–3.57, p<0.001), B symptoms (OR=3.51, 95% CI=2.34–5.29, p<0.001), and extranodal disease (OR=2.90, 95% CI=2.32–3.63, p<0.001).ConclusionA lower GNRI level predicted poorer short- and long-term prognosis in patients with DLBCL. A low GNRI was correlated with clinical factors of disease progression in DLBCL patients.https://www.frontiersin.org/articles/10.3389/fonc.2023.1169749/fullgeriatric nutritional risk indexmeta-analysisdiffuse large B-cell lymphomaprognosisclinical practice |
| spellingShingle | Dan Cao Zongxin Zhang Prognostic and clinicopathological role of geriatric nutritional risk index in patients with diffuse large B-cell lymphoma: A meta-analysis Frontiers in Oncology geriatric nutritional risk index meta-analysis diffuse large B-cell lymphoma prognosis clinical practice |
| title | Prognostic and clinicopathological role of geriatric nutritional risk index in patients with diffuse large B-cell lymphoma: A meta-analysis |
| title_full | Prognostic and clinicopathological role of geriatric nutritional risk index in patients with diffuse large B-cell lymphoma: A meta-analysis |
| title_fullStr | Prognostic and clinicopathological role of geriatric nutritional risk index in patients with diffuse large B-cell lymphoma: A meta-analysis |
| title_full_unstemmed | Prognostic and clinicopathological role of geriatric nutritional risk index in patients with diffuse large B-cell lymphoma: A meta-analysis |
| title_short | Prognostic and clinicopathological role of geriatric nutritional risk index in patients with diffuse large B-cell lymphoma: A meta-analysis |
| title_sort | prognostic and clinicopathological role of geriatric nutritional risk index in patients with diffuse large b cell lymphoma a meta analysis |
| topic | geriatric nutritional risk index meta-analysis diffuse large B-cell lymphoma prognosis clinical practice |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1169749/full |
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