Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype

Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype

<p>Abstract</p> <p>Background</p> <p>Genetic instability is a hallmark of tumours and preneoplastic lesions. The predominant form of genome instability in human cancer is chromosome instability (CIN). CIN is characterized by chromosomal aberrations, gains or losses of w...

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Bibliographic Details
Main Authors:	Schillaci Tiziana, Amato Angela, Lentini Laura, Di Leonardo Aldo
Format:	Article
Language:	English
Published:	BMC 2007-11-01
Series:	BMC Cancer
Online Access:	http://www.biomedcentral.com/1471-2407/7/212

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