Aging is not associated with proteasome impairment in UPS reporter mice.
Covalent linkage of ubiquitin regulates the function and, ultimately, the degradation of many proteins by the ubiquitin-proteasome system (UPS). Given its essential role in protein regulation, even slight perturbations in UPS activity can substantially impair cellular function.We have generated and...
Main Authors: | Casey Cook, Jennifer Gass, Judith Dunmore, Jimei Tong, Julie Taylor, Jason Eriksen, Eileen McGowan, Jada Lewis, Jennifer Johnston, Leonard Petrucelli |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-06-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2690827?pdf=render |
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