Epstein-Barr Virus Infection in Childhood May Precipitate Atopic Diseases
Background: Epstein Barr virus (EBV) has been suspected of being involved in the development of atopy. There are several studies suggesting a positive as well as negative association between EBV infection and atopic diseases. Here, we carried out a large-scale, systematic investigation to address th...
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| Format: | Article |
| Language: | English |
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Elsevier
2005-01-01
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| Series: | Allergology International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015310625 |
| _version_ | 1818112473921748992 |
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| author | Reiko Okudaira Tokuko Mukoyama Naohito Suzuki Kohei Hashizume Tsutomu Iwata Fumiko Juji Yoichi Kohno Fujio Takeuchi Hiroshi Shuto Hirokazu Okudaira |
| author_facet | Reiko Okudaira Tokuko Mukoyama Naohito Suzuki Kohei Hashizume Tsutomu Iwata Fumiko Juji Yoichi Kohno Fujio Takeuchi Hiroshi Shuto Hirokazu Okudaira |
| author_sort | Reiko Okudaira |
| collection | DOAJ |
| description | Background: Epstein Barr virus (EBV) has been suspected of being involved in the development of atopy. There are several studies suggesting a positive as well as negative association between EBV infection and atopic diseases. Here, we carried out a large-scale, systematic investigation to address the issue of the possible association between EBV infection and atopic diseases.
Methods: Anti-EBV-viral capsid antigen (VCA) antibody titer, anti-EBV nuclear antigen (EBNA) antibody titer, atypical lymphocyte (AtLy) count and EBV-DNA copy number in 106 WBC were examined as evidence for EBV infection, and characteristic parameters of atopic disease such as total serum immunoglobulin E (IgE) level, highest antigen-specific IgE antibody titer (h-RAST) and peripheral blood eosinophil (Eos) count were measured and compared among atopic subjects and non-atopic controls, and correlations between parameters of atopy and EBV infection were subjected to statistical analysis.
Results: Anti-EBV, in particular anti-EBNA antibody titer and AtLy count in peripheral blood were markedly higher in patients with bronchial asthma (BA) and/or atopic dermatitis (AD) than in non-atopic controls, especially in early childhood. No similar findings were obtained for antibodies to cytomegalovirus (CMV). EBV-DNA copy numbers in WBC were elevated in atopic subjects. Correlations between EBV-DNA copy number and other parameters of EBV infection (anti-EBV antibody titer and AtLy count) but those with cytomegalovirus (CMV) infection and markers of atopic disease (IgE, h-RAST level, and Eos count) were demonstrated. It was found that anti-EBNA seronegative atopics have higher copy numbers of EBV DNA in WBC and more elevated levels of IgE and h-RAST than anti-EBNA seropositive atopics. Anti-EBV VCA antibody titer in individuals aged 15 years and younger and anti-EBNA antibody titer among Japanese were suggested to have declined considerably in the past 15 years.
Conclusions: The present study suggests that EBV infection in early childhood could precipitate atopic diseases. |
| first_indexed | 2024-12-11T03:19:30Z |
| format | Article |
| id | doaj.art-b0164e47bc6d423ca8675992df5d42ac |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-11T03:19:30Z |
| publishDate | 2005-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-b0164e47bc6d423ca8675992df5d42ac2022-12-22T01:22:39ZengElsevierAllergology International1323-89302005-01-0154348349010.2332/allergolint.54.483Epstein-Barr Virus Infection in Childhood May Precipitate Atopic DiseasesReiko Okudaira0Tokuko Mukoyama1Naohito Suzuki2Kohei Hashizume3Tsutomu Iwata4Fumiko Juji5Yoichi Kohno6Fujio Takeuchi7Hiroshi Shuto8Hirokazu Okudaira9Departments of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.Department of Pediatrics, Doai Memorial Hospital, Tokyo, Japan.Allergy and Respiratory Medicine, Doai Memorial Hospital, Tokyo, Japan.Pediatric Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.Department of Pediatrics, Japan Allergy Research Institute, Tokyo, Japan.Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.Ekibiru-iin Sengendai Hospital, Saitama, Japan.Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.Background: Epstein Barr virus (EBV) has been suspected of being involved in the development of atopy. There are several studies suggesting a positive as well as negative association between EBV infection and atopic diseases. Here, we carried out a large-scale, systematic investigation to address the issue of the possible association between EBV infection and atopic diseases. Methods: Anti-EBV-viral capsid antigen (VCA) antibody titer, anti-EBV nuclear antigen (EBNA) antibody titer, atypical lymphocyte (AtLy) count and EBV-DNA copy number in 106 WBC were examined as evidence for EBV infection, and characteristic parameters of atopic disease such as total serum immunoglobulin E (IgE) level, highest antigen-specific IgE antibody titer (h-RAST) and peripheral blood eosinophil (Eos) count were measured and compared among atopic subjects and non-atopic controls, and correlations between parameters of atopy and EBV infection were subjected to statistical analysis. Results: Anti-EBV, in particular anti-EBNA antibody titer and AtLy count in peripheral blood were markedly higher in patients with bronchial asthma (BA) and/or atopic dermatitis (AD) than in non-atopic controls, especially in early childhood. No similar findings were obtained for antibodies to cytomegalovirus (CMV). EBV-DNA copy numbers in WBC were elevated in atopic subjects. Correlations between EBV-DNA copy number and other parameters of EBV infection (anti-EBV antibody titer and AtLy count) but those with cytomegalovirus (CMV) infection and markers of atopic disease (IgE, h-RAST level, and Eos count) were demonstrated. It was found that anti-EBNA seronegative atopics have higher copy numbers of EBV DNA in WBC and more elevated levels of IgE and h-RAST than anti-EBNA seropositive atopics. Anti-EBV VCA antibody titer in individuals aged 15 years and younger and anti-EBNA antibody titer among Japanese were suggested to have declined considerably in the past 15 years. Conclusions: The present study suggests that EBV infection in early childhood could precipitate atopic diseases.http://www.sciencedirect.com/science/article/pii/S1323893015310625atopic dermatitisatopybronchial asthmaEpstein-Barr virusinfection |
| spellingShingle | Reiko Okudaira Tokuko Mukoyama Naohito Suzuki Kohei Hashizume Tsutomu Iwata Fumiko Juji Yoichi Kohno Fujio Takeuchi Hiroshi Shuto Hirokazu Okudaira Epstein-Barr Virus Infection in Childhood May Precipitate Atopic Diseases Allergology International atopic dermatitis atopy bronchial asthma Epstein-Barr virus infection |
| title | Epstein-Barr Virus Infection in Childhood May Precipitate Atopic Diseases |
| title_full | Epstein-Barr Virus Infection in Childhood May Precipitate Atopic Diseases |
| title_fullStr | Epstein-Barr Virus Infection in Childhood May Precipitate Atopic Diseases |
| title_full_unstemmed | Epstein-Barr Virus Infection in Childhood May Precipitate Atopic Diseases |
| title_short | Epstein-Barr Virus Infection in Childhood May Precipitate Atopic Diseases |
| title_sort | epstein barr virus infection in childhood may precipitate atopic diseases |
| topic | atopic dermatitis atopy bronchial asthma Epstein-Barr virus infection |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015310625 |
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