Brain‐derived neurotrophic factor (BDNF) levels in panic disorder: A systematic review and meta‐analysis
Abstract Background The existing literature on the association between brain‐derived neurotrophic factor (BDNF) protein levels and panic disorder presents inconsistent findings. This systematic review and meta‐analysis aim to synthesize the available evidence and determine the overall effect of BDNF...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.3349 |
| _version_ | 1797263417103351808 |
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| author | Arman Shafiee Kyana Jafarabady Ida Mohammadi Shahryar Rajai |
| author_facet | Arman Shafiee Kyana Jafarabady Ida Mohammadi Shahryar Rajai |
| author_sort | Arman Shafiee |
| collection | DOAJ |
| description | Abstract Background The existing literature on the association between brain‐derived neurotrophic factor (BDNF) protein levels and panic disorder presents inconsistent findings. This systematic review and meta‐analysis aim to synthesize the available evidence and determine the overall effect of BDNF protein levels in individuals diagnosed with panic disorder. Methods A comprehensive literature search was conducted using electronic databases (PubMed, Embase, Scopus, PsycINFO, and Web of Science) from inception to April 21, 2023. The search strategy included relevant keywords and medical subject headings terms related to BDNF, panic disorder, and protein levels. A random‐effects model was used for the meta‐analysis, and subgroup analyses were performed to explore heterogeneity. Publication bias was assessed using funnel plots and statistical tests. Results A total of 12 studies met the inclusion criteria. The meta‐analysis demonstrated a significant decrease in BDNF protein levels in individuals with panic disorder (SMD = −.53, 95% CI: −1.02 to −.04, p < .001; I2: 92%). The results of subgroup and meta‐regression analyses were not statistically significant. No significant publication bias was observed based on the results of Egger's regression test (p‐value = .3550). Conclusion This systematic review and meta‐analysis provide evidence of lower BDNF protein levels in individuals diagnosed with panic disorder compared to healthy controls. The findings suggest a potential role for BDNF dysregulation in the pathophysiology of panic disorder. Further research is warranted to elucidate the underlying mechanisms and potential therapeutic implications. |
| first_indexed | 2024-03-07T23:34:46Z |
| format | Article |
| id | doaj.art-b01686c8546343b092d211080f11165e |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-04-25T00:12:40Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-b01686c8546343b092d211080f11165e2024-03-13T10:15:39ZengWileyBrain and Behavior2162-32792024-01-01141n/an/a10.1002/brb3.3349Brain‐derived neurotrophic factor (BDNF) levels in panic disorder: A systematic review and meta‐analysisArman Shafiee0Kyana Jafarabady1Ida Mohammadi2Shahryar Rajai3Department of Psychiatry and Mental Health Alborz University of Medical Sciences Karaj IranStudent Research Committee, School of Medicine Alborz University of Medical Sciences Karaj IranSchool of Medicine Shahid Beheshti University of Medical Sciences Tehran IranSchool of Medicine Shahid Beheshti University of Medical Sciences Tehran IranAbstract Background The existing literature on the association between brain‐derived neurotrophic factor (BDNF) protein levels and panic disorder presents inconsistent findings. This systematic review and meta‐analysis aim to synthesize the available evidence and determine the overall effect of BDNF protein levels in individuals diagnosed with panic disorder. Methods A comprehensive literature search was conducted using electronic databases (PubMed, Embase, Scopus, PsycINFO, and Web of Science) from inception to April 21, 2023. The search strategy included relevant keywords and medical subject headings terms related to BDNF, panic disorder, and protein levels. A random‐effects model was used for the meta‐analysis, and subgroup analyses were performed to explore heterogeneity. Publication bias was assessed using funnel plots and statistical tests. Results A total of 12 studies met the inclusion criteria. The meta‐analysis demonstrated a significant decrease in BDNF protein levels in individuals with panic disorder (SMD = −.53, 95% CI: −1.02 to −.04, p < .001; I2: 92%). The results of subgroup and meta‐regression analyses were not statistically significant. No significant publication bias was observed based on the results of Egger's regression test (p‐value = .3550). Conclusion This systematic review and meta‐analysis provide evidence of lower BDNF protein levels in individuals diagnosed with panic disorder compared to healthy controls. The findings suggest a potential role for BDNF dysregulation in the pathophysiology of panic disorder. Further research is warranted to elucidate the underlying mechanisms and potential therapeutic implications.https://doi.org/10.1002/brb3.3349anxietybrain‐derived neurotrophic factorpanic |
| spellingShingle | Arman Shafiee Kyana Jafarabady Ida Mohammadi Shahryar Rajai Brain‐derived neurotrophic factor (BDNF) levels in panic disorder: A systematic review and meta‐analysis Brain and Behavior anxiety brain‐derived neurotrophic factor panic |
| title | Brain‐derived neurotrophic factor (BDNF) levels in panic disorder: A systematic review and meta‐analysis |
| title_full | Brain‐derived neurotrophic factor (BDNF) levels in panic disorder: A systematic review and meta‐analysis |
| title_fullStr | Brain‐derived neurotrophic factor (BDNF) levels in panic disorder: A systematic review and meta‐analysis |
| title_full_unstemmed | Brain‐derived neurotrophic factor (BDNF) levels in panic disorder: A systematic review and meta‐analysis |
| title_short | Brain‐derived neurotrophic factor (BDNF) levels in panic disorder: A systematic review and meta‐analysis |
| title_sort | brain derived neurotrophic factor bdnf levels in panic disorder a systematic review and meta analysis |
| topic | anxiety brain‐derived neurotrophic factor panic |
| url | https://doi.org/10.1002/brb3.3349 |
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