Synthesis and cytotoxicity evaluation of fluorinated brusatol, bruceosin, and dehydrobrusatol
Three fluorinated quassinoid analogues—4α-fluorobruceosin, 1α-fluorobrusatol, and 1-fluorodehydrobrusatol—were synthesized from brusatol, bruceosin, and dehydrobrusatol, respectively, by treatment with Selectfluor. These analogues were less cytotoxic to HL-60 cells than their non-fluorinated counter...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715623002278 |
| _version_ | 1797799033425625088 |
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| author | Yukio Hitotsuyanagi Ryotaro Yokoyama Huiyu Ren Daiki Nojima Yu Tokumaru Tomoyo Hasuda |
| author_facet | Yukio Hitotsuyanagi Ryotaro Yokoyama Huiyu Ren Daiki Nojima Yu Tokumaru Tomoyo Hasuda |
| author_sort | Yukio Hitotsuyanagi |
| collection | DOAJ |
| description | Three fluorinated quassinoid analogues—4α-fluorobruceosin, 1α-fluorobrusatol, and 1-fluorodehydrobrusatol—were synthesized from brusatol, bruceosin, and dehydrobrusatol, respectively, by treatment with Selectfluor. These analogues were less cytotoxic to HL-60 cells than their non-fluorinated counterparts. |
| first_indexed | 2024-03-13T04:12:49Z |
| format | Article |
| id | doaj.art-b0179b8be93c4e7fbf513f8c79c56219 |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-03-13T04:12:49Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-b0179b8be93c4e7fbf513f8c79c562192023-06-21T06:52:49ZengElsevierResults in Chemistry2211-71562023-01-015100988Synthesis and cytotoxicity evaluation of fluorinated brusatol, bruceosin, and dehydrobrusatolYukio Hitotsuyanagi0Ryotaro Yokoyama1Huiyu Ren2Daiki Nojima3Yu Tokumaru4Tomoyo Hasuda5Corresponding author.; School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, JapanSchool of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, JapanSchool of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, JapanSchool of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, JapanSchool of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, JapanSchool of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, JapanThree fluorinated quassinoid analogues—4α-fluorobruceosin, 1α-fluorobrusatol, and 1-fluorodehydrobrusatol—were synthesized from brusatol, bruceosin, and dehydrobrusatol, respectively, by treatment with Selectfluor. These analogues were less cytotoxic to HL-60 cells than their non-fluorinated counterparts.http://www.sciencedirect.com/science/article/pii/S2211715623002278BrusatolQuassinoidSemi-synthesisFluoro analogueCytotoxicity |
| spellingShingle | Yukio Hitotsuyanagi Ryotaro Yokoyama Huiyu Ren Daiki Nojima Yu Tokumaru Tomoyo Hasuda Synthesis and cytotoxicity evaluation of fluorinated brusatol, bruceosin, and dehydrobrusatol Results in Chemistry Brusatol Quassinoid Semi-synthesis Fluoro analogue Cytotoxicity |
| title | Synthesis and cytotoxicity evaluation of fluorinated brusatol, bruceosin, and dehydrobrusatol |
| title_full | Synthesis and cytotoxicity evaluation of fluorinated brusatol, bruceosin, and dehydrobrusatol |
| title_fullStr | Synthesis and cytotoxicity evaluation of fluorinated brusatol, bruceosin, and dehydrobrusatol |
| title_full_unstemmed | Synthesis and cytotoxicity evaluation of fluorinated brusatol, bruceosin, and dehydrobrusatol |
| title_short | Synthesis and cytotoxicity evaluation of fluorinated brusatol, bruceosin, and dehydrobrusatol |
| title_sort | synthesis and cytotoxicity evaluation of fluorinated brusatol bruceosin and dehydrobrusatol |
| topic | Brusatol Quassinoid Semi-synthesis Fluoro analogue Cytotoxicity |
| url | http://www.sciencedirect.com/science/article/pii/S2211715623002278 |
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