EGFR mutations are significantly associated with visceral pleural invasion development in non-small-cell lung cancer patients
Jinghan Shi, Yang Yang, Yanfeng Zhao, Junjie Zhu, Xiao Song, Gening Jiang Department of Thoracic Surgery, Shanghai Pulmonary Hospital affiliated to Tongji University, Shanghai, China Objectives: A retrospective study was performed to investigate the association between EGFR mutations and visceral pl...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-03-01
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| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/egfr-mutations-are-significantly-associated-with-visceral-pleural-inva-peer-reviewed-article-CMAR |
| _version_ | 1811269095419543552 |
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| author | Shi J Yang Y Zhao Y Zhu J Song X Jiang G |
| author_facet | Shi J Yang Y Zhao Y Zhu J Song X Jiang G |
| author_sort | Shi J |
| collection | DOAJ |
| description | Jinghan Shi, Yang Yang, Yanfeng Zhao, Junjie Zhu, Xiao Song, Gening Jiang Department of Thoracic Surgery, Shanghai Pulmonary Hospital affiliated to Tongji University, Shanghai, China Objectives: A retrospective study was performed to investigate the association between EGFR mutations and visceral pleural invasion (VPI), and evaluate the prognostic value of EGFR in resected non-small-cell lung cancer (NSCLC) patients with VPI.Materials and methods: Clinicopathological characteristics and follow-up information were collected from 508 consecutive patients with surgically resected stage I–III NSCLC, and EGFR mutations were detected based on real-time PCR technology. Significant results (P<0.05) from univariate logistic regression analysis were involved as covariates to adjust confounding factors in the analysis of independent factors.Results: VPI and EGFR mutations were detected in 229 (45.1%) and 243 (47.8%) cases in NSCLC, respectively. There was a significant association between EGFR mutations and VPI development. Both 19-del (adjusted OR =2.13, 95%CI =1.13–3.99, P=0.019) and L858R (adjusted OR =2.89, 95%CI =1.59–5.29, P=0.001) could significantly increase the risk of VPI development compared with EGFR wild-type. Higher frequency of L858R (adjusted OR =2.63, 95%CI =1.42–4.88, P=0.002) was detected in VPI patients compared with non-VPI patients. 19-del (adjusted HR =0.31, 95%CI =0.12–0.80, P=0.015) was an independent prognostic factor for a better disease-free survival (DFS) in non-VPI patients. No significant association was shown between EGFR mutations and DFS in VPI patients.Conclusion: EGFR mutations were significantly associated with VPI development in NSCLC, but no significant association was observed between EGFR mutations and DFS in the patients with VPI. 19-del was a favorable prognostic factor for DFS in non-VPI patients. Keywords: EGFR mutations, visceral pleural invasion, non-small-cell lung cancer, association study |
| first_indexed | 2024-04-12T21:34:51Z |
| format | Article |
| id | doaj.art-b01a12d181304e8f828cc58e807c0091 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-04-12T21:34:51Z |
| publishDate | 2019-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-b01a12d181304e8f828cc58e807c00912022-12-22T03:15:55ZengDove Medical PressCancer Management and Research1179-13222019-03-01Volume 111945195744411EGFR mutations are significantly associated with visceral pleural invasion development in non-small-cell lung cancer patientsShi JYang YZhao YZhu JSong XJiang GJinghan Shi, Yang Yang, Yanfeng Zhao, Junjie Zhu, Xiao Song, Gening Jiang Department of Thoracic Surgery, Shanghai Pulmonary Hospital affiliated to Tongji University, Shanghai, China Objectives: A retrospective study was performed to investigate the association between EGFR mutations and visceral pleural invasion (VPI), and evaluate the prognostic value of EGFR in resected non-small-cell lung cancer (NSCLC) patients with VPI.Materials and methods: Clinicopathological characteristics and follow-up information were collected from 508 consecutive patients with surgically resected stage I–III NSCLC, and EGFR mutations were detected based on real-time PCR technology. Significant results (P<0.05) from univariate logistic regression analysis were involved as covariates to adjust confounding factors in the analysis of independent factors.Results: VPI and EGFR mutations were detected in 229 (45.1%) and 243 (47.8%) cases in NSCLC, respectively. There was a significant association between EGFR mutations and VPI development. Both 19-del (adjusted OR =2.13, 95%CI =1.13–3.99, P=0.019) and L858R (adjusted OR =2.89, 95%CI =1.59–5.29, P=0.001) could significantly increase the risk of VPI development compared with EGFR wild-type. Higher frequency of L858R (adjusted OR =2.63, 95%CI =1.42–4.88, P=0.002) was detected in VPI patients compared with non-VPI patients. 19-del (adjusted HR =0.31, 95%CI =0.12–0.80, P=0.015) was an independent prognostic factor for a better disease-free survival (DFS) in non-VPI patients. No significant association was shown between EGFR mutations and DFS in VPI patients.Conclusion: EGFR mutations were significantly associated with VPI development in NSCLC, but no significant association was observed between EGFR mutations and DFS in the patients with VPI. 19-del was a favorable prognostic factor for DFS in non-VPI patients. Keywords: EGFR mutations, visceral pleural invasion, non-small-cell lung cancer, association study https://www.dovepress.com/egfr-mutations-are-significantly-associated-with-visceral-pleural-inva-peer-reviewed-article-CMAREGFR mutationsvisceral pleural invasionnon-small cell lung cancerassociation study |
| spellingShingle | Shi J Yang Y Zhao Y Zhu J Song X Jiang G EGFR mutations are significantly associated with visceral pleural invasion development in non-small-cell lung cancer patients Cancer Management and Research EGFR mutations visceral pleural invasion non-small cell lung cancer association study |
| title | EGFR mutations are significantly associated with visceral pleural invasion development in non-small-cell lung cancer patients |
| title_full | EGFR mutations are significantly associated with visceral pleural invasion development in non-small-cell lung cancer patients |
| title_fullStr | EGFR mutations are significantly associated with visceral pleural invasion development in non-small-cell lung cancer patients |
| title_full_unstemmed | EGFR mutations are significantly associated with visceral pleural invasion development in non-small-cell lung cancer patients |
| title_short | EGFR mutations are significantly associated with visceral pleural invasion development in non-small-cell lung cancer patients |
| title_sort | egfr mutations are significantly associated with visceral pleural invasion development in non small cell lung cancer patients |
| topic | EGFR mutations visceral pleural invasion non-small cell lung cancer association study |
| url | https://www.dovepress.com/egfr-mutations-are-significantly-associated-with-visceral-pleural-inva-peer-reviewed-article-CMAR |
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