Fast simultaneous determination of 23 veterinary drug residues in fish, poultry, and red meat by liquid chromatography/tandem mass spectrometry
The misuses of veterinary drugs can result in the accumulation of residues in food of animal origin that can make its way to the final consumer. Herein we describe a simple method for the accurate determination of beta-lactams, quinolones, sulphonamides, and tetracyclines in fish, poultry, and red m...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535222004324 |
| _version_ | 1798036387971203072 |
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| author | Abdullah Al Tamim Saeed Alzahrani Sarah Al-Subaie Mohammed A. Almutairi Ahmed Al Jaber Abdullah M. Alowaifeer |
| author_facet | Abdullah Al Tamim Saeed Alzahrani Sarah Al-Subaie Mohammed A. Almutairi Ahmed Al Jaber Abdullah M. Alowaifeer |
| author_sort | Abdullah Al Tamim |
| collection | DOAJ |
| description | The misuses of veterinary drugs can result in the accumulation of residues in food of animal origin that can make its way to the final consumer. Herein we describe a simple method for the accurate determination of beta-lactams, quinolones, sulphonamides, and tetracyclines in fish, poultry, and red meat. No extraction cartridges were used; instead, the extraction process consisted of the addition of an organic solvents, shaking, centrifugation, and dilution. An extensive validation process demonstrated an excellent linearity (R2 ≥ 0.99) for 23-drug residues. The recovery of drugs in different matrices at two concentration levels (n = 6) was in the range of 82–119%. The method was proved to be repeatable and reproducible with intra/inter-day measurements (RSDs lower than 20%). The quantification limits of drug residues were in the range of 0.8 to 45.3 ug/kg, which is well below the maximum residue limits set by most regulatory authorities. This method was successfully applied to the routine analysis of 20 fish, poultry, and red meat samples (n = 60). |
| first_indexed | 2024-04-11T21:12:12Z |
| format | Article |
| id | doaj.art-b01aec0b2a2345368b50ee97bfb03dce |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-04-11T21:12:12Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-b01aec0b2a2345368b50ee97bfb03dce2022-12-22T04:03:00ZengElsevierArabian Journal of Chemistry1878-53522022-10-011510104116Fast simultaneous determination of 23 veterinary drug residues in fish, poultry, and red meat by liquid chromatography/tandem mass spectrometryAbdullah Al Tamim0Saeed Alzahrani1Sarah Al-Subaie2Mohammed A. Almutairi3Ahmed Al Jaber4Abdullah M. Alowaifeer5Refernce Laboratory for Food Chemistry, Riyadh, Saudi Food & Drug Authority (SFDA), Saudi ArabiaFood Laboratory, Riyadh, Saudi Food & Drug Authority (SFDA), Saudi ArabiaRefernce Laboratory for Food Chemistry, Riyadh, Saudi Food & Drug Authority (SFDA), Saudi ArabiaRefernce Laboratory for Food Chemistry, Riyadh, Saudi Food & Drug Authority (SFDA), Saudi ArabiaFood Laboratory, Riyadh, Saudi Food & Drug Authority (SFDA), Saudi ArabiaRefernce Laboratory for Food Chemistry, Riyadh, Saudi Food & Drug Authority (SFDA), Saudi Arabia; Corresponding author.The misuses of veterinary drugs can result in the accumulation of residues in food of animal origin that can make its way to the final consumer. Herein we describe a simple method for the accurate determination of beta-lactams, quinolones, sulphonamides, and tetracyclines in fish, poultry, and red meat. No extraction cartridges were used; instead, the extraction process consisted of the addition of an organic solvents, shaking, centrifugation, and dilution. An extensive validation process demonstrated an excellent linearity (R2 ≥ 0.99) for 23-drug residues. The recovery of drugs in different matrices at two concentration levels (n = 6) was in the range of 82–119%. The method was proved to be repeatable and reproducible with intra/inter-day measurements (RSDs lower than 20%). The quantification limits of drug residues were in the range of 0.8 to 45.3 ug/kg, which is well below the maximum residue limits set by most regulatory authorities. This method was successfully applied to the routine analysis of 20 fish, poultry, and red meat samples (n = 60).http://www.sciencedirect.com/science/article/pii/S1878535222004324Multi-residueVeterinary drugsFishPoultryRed meatLC-MS/MS |
| spellingShingle | Abdullah Al Tamim Saeed Alzahrani Sarah Al-Subaie Mohammed A. Almutairi Ahmed Al Jaber Abdullah M. Alowaifeer Fast simultaneous determination of 23 veterinary drug residues in fish, poultry, and red meat by liquid chromatography/tandem mass spectrometry Arabian Journal of Chemistry Multi-residue Veterinary drugs Fish Poultry Red meat LC-MS/MS |
| title | Fast simultaneous determination of 23 veterinary drug residues in fish, poultry, and red meat by liquid chromatography/tandem mass spectrometry |
| title_full | Fast simultaneous determination of 23 veterinary drug residues in fish, poultry, and red meat by liquid chromatography/tandem mass spectrometry |
| title_fullStr | Fast simultaneous determination of 23 veterinary drug residues in fish, poultry, and red meat by liquid chromatography/tandem mass spectrometry |
| title_full_unstemmed | Fast simultaneous determination of 23 veterinary drug residues in fish, poultry, and red meat by liquid chromatography/tandem mass spectrometry |
| title_short | Fast simultaneous determination of 23 veterinary drug residues in fish, poultry, and red meat by liquid chromatography/tandem mass spectrometry |
| title_sort | fast simultaneous determination of 23 veterinary drug residues in fish poultry and red meat by liquid chromatography tandem mass spectrometry |
| topic | Multi-residue Veterinary drugs Fish Poultry Red meat LC-MS/MS |
| url | http://www.sciencedirect.com/science/article/pii/S1878535222004324 |
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