Evaluation of wound healing and antimicrobial properties of aqueous extract from Bowdichia virgilioides stem barks in mice
The decoction of the stem barks from Bowdichia virgilioides KUNTH is a folk remedy used to treat inflammatory disorders in Latin American and Brazil. In the present study, the wound healing activity of aqueous extract of the stem bark from B. virgilioides, called AEBv, was evaluated by the rate of h...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2013-09-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000300945&lng=en&tlng=en |
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| author | ISABELA K.R. AGRA LUANA L.S. PIRES PAULO S.M. CARVALHO EURIPEDES A. SILVA-FILHO SALETE SMANIOTTO EMILIANO BARRETO |
| author_facet | ISABELA K.R. AGRA LUANA L.S. PIRES PAULO S.M. CARVALHO EURIPEDES A. SILVA-FILHO SALETE SMANIOTTO EMILIANO BARRETO |
| author_sort | ISABELA K.R. AGRA |
| collection | DOAJ |
| description | The decoction of the stem barks from Bowdichia virgilioides KUNTH is a folk remedy used to treat inflammatory disorders in Latin American and Brazil. In the present study, the wound healing activity of aqueous extract of the stem bark from B. virgilioides, called AEBv, was evaluated by the rate of healing by wound contraction and period of epithelization at different days post-wound using the wound excisional model. On day 9, the AEBv-treated animals exhibited significative reduction in the wound area when compared with controls. In wound infected with S. aureus, the AEBv significantly improved the wound contraction when compared to the saline-treated mice. The histological analysis showed that AEBv induced a collagen deposition, increase in the fibroblast count and few inflammatory cells than compared to saline-treated group. The expression of collagen type I was increased in the group treated with AEBv as indicated by immunohistochemical staining. In vitro, the AEBv was effective only against S. aureus but not against P. aeruginosa. Together, the results of this study demonstrate, for the first time, the healing and antimicrobiological effects of aqueous extract of the stem bark from B. virgilioides in the therapy of skin wounds. |
| first_indexed | 2024-04-12T18:02:36Z |
| format | Article |
| id | doaj.art-b01b138bf7dc49518a90b8206bc9f4a2 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-04-12T18:02:36Z |
| publishDate | 2013-09-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-b01b138bf7dc49518a90b8206bc9f4a22022-12-22T03:22:07ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902013-09-0185394595410.1590/S0001-37652013005000049S0001-37652013000300945Evaluation of wound healing and antimicrobial properties of aqueous extract from Bowdichia virgilioides stem barks in miceISABELA K.R. AGRALUANA L.S. PIRESPAULO S.M. CARVALHOEURIPEDES A. SILVA-FILHOSALETE SMANIOTTOEMILIANO BARRETOThe decoction of the stem barks from Bowdichia virgilioides KUNTH is a folk remedy used to treat inflammatory disorders in Latin American and Brazil. In the present study, the wound healing activity of aqueous extract of the stem bark from B. virgilioides, called AEBv, was evaluated by the rate of healing by wound contraction and period of epithelization at different days post-wound using the wound excisional model. On day 9, the AEBv-treated animals exhibited significative reduction in the wound area when compared with controls. In wound infected with S. aureus, the AEBv significantly improved the wound contraction when compared to the saline-treated mice. The histological analysis showed that AEBv induced a collagen deposition, increase in the fibroblast count and few inflammatory cells than compared to saline-treated group. The expression of collagen type I was increased in the group treated with AEBv as indicated by immunohistochemical staining. In vitro, the AEBv was effective only against S. aureus but not against P. aeruginosa. Together, the results of this study demonstrate, for the first time, the healing and antimicrobiological effects of aqueous extract of the stem bark from B. virgilioides in the therapy of skin wounds.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000300945&lng=en&tlng=enCicatrizacao de feridasefeito antimicrobianoBowdichia virgilioidesplanta medicinal |
| spellingShingle | ISABELA K.R. AGRA LUANA L.S. PIRES PAULO S.M. CARVALHO EURIPEDES A. SILVA-FILHO SALETE SMANIOTTO EMILIANO BARRETO Evaluation of wound healing and antimicrobial properties of aqueous extract from Bowdichia virgilioides stem barks in mice Anais da Academia Brasileira de Ciências Cicatrizacao de feridas efeito antimicrobiano Bowdichia virgilioides planta medicinal |
| title | Evaluation of wound healing and antimicrobial properties of aqueous extract from Bowdichia virgilioides stem barks in mice |
| title_full | Evaluation of wound healing and antimicrobial properties of aqueous extract from Bowdichia virgilioides stem barks in mice |
| title_fullStr | Evaluation of wound healing and antimicrobial properties of aqueous extract from Bowdichia virgilioides stem barks in mice |
| title_full_unstemmed | Evaluation of wound healing and antimicrobial properties of aqueous extract from Bowdichia virgilioides stem barks in mice |
| title_short | Evaluation of wound healing and antimicrobial properties of aqueous extract from Bowdichia virgilioides stem barks in mice |
| title_sort | evaluation of wound healing and antimicrobial properties of aqueous extract from bowdichia virgilioides stem barks in mice |
| topic | Cicatrizacao de feridas efeito antimicrobiano Bowdichia virgilioides planta medicinal |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000300945&lng=en&tlng=en |
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