Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response
Antimicrobial peptides (AMPs) with antiviral activity (antiviral peptides: AVPs) have become a research hotspot and already show immense potential to become pharmaceutically available antiviral drugs. AVPs have exhibited huge potential in inhibiting viruses by targeting various stages of their life...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.02030/full |
| _version_ | 1818160179248627712 |
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| author | Min Feng Min Feng Shigang Fei Junming Xia Vassiliki Labropoulou Luc Swevers Jingchen Sun |
| author_facet | Min Feng Min Feng Shigang Fei Junming Xia Vassiliki Labropoulou Luc Swevers Jingchen Sun |
| author_sort | Min Feng |
| collection | DOAJ |
| description | Antimicrobial peptides (AMPs) with antiviral activity (antiviral peptides: AVPs) have become a research hotspot and already show immense potential to become pharmaceutically available antiviral drugs. AVPs have exhibited huge potential in inhibiting viruses by targeting various stages of their life cycle. Insects are the most speciose group of animals that inhabit almost all ecosystems and habitats on the land and are a rich source of natural AMPs. However, insect AVP mining, functional research, and drug development are still in their infancy. This review aims to summarize the currently validated insect AVPs, explore potential new insect AVPs and to discuss their possible mechanism of synthesis and action, with a view to providing clues to unravel the mechanisms of insect antiviral immunity and to develop insect AVP-derived antiviral drugs. |
| first_indexed | 2024-12-11T15:57:46Z |
| format | Article |
| id | doaj.art-b01b6f16272b4b859ad86653e904455a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T15:57:46Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b01b6f16272b4b859ad86653e904455a2022-12-22T00:59:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-09-011110.3389/fimmu.2020.02030573073Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune ResponseMin Feng0Min Feng1Shigang Fei2Junming Xia3Vassiliki Labropoulou4Luc Swevers5Jingchen Sun6Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, ChinaInsect Molecular Genetics and Biotechnology, Institute of Biosciences and Applications, National Centre for Scientific Research Demokritos, Athens, GreeceGuangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, ChinaInsect Molecular Genetics and Biotechnology, Institute of Biosciences and Applications, National Centre for Scientific Research Demokritos, Athens, GreeceInsect Molecular Genetics and Biotechnology, Institute of Biosciences and Applications, National Centre for Scientific Research Demokritos, Athens, GreeceGuangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, ChinaAntimicrobial peptides (AMPs) with antiviral activity (antiviral peptides: AVPs) have become a research hotspot and already show immense potential to become pharmaceutically available antiviral drugs. AVPs have exhibited huge potential in inhibiting viruses by targeting various stages of their life cycle. Insects are the most speciose group of animals that inhabit almost all ecosystems and habitats on the land and are a rich source of natural AMPs. However, insect AVP mining, functional research, and drug development are still in their infancy. This review aims to summarize the currently validated insect AVPs, explore potential new insect AVPs and to discuss their possible mechanism of synthesis and action, with a view to providing clues to unravel the mechanisms of insect antiviral immunity and to develop insect AVP-derived antiviral drugs.https://www.frontiersin.org/article/10.3389/fimmu.2020.02030/fullantiviral peptidesantimicrobial peptidesinsectvirusesantiviral drugs |
| spellingShingle | Min Feng Min Feng Shigang Fei Junming Xia Vassiliki Labropoulou Luc Swevers Jingchen Sun Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response Frontiers in Immunology antiviral peptides antimicrobial peptides insect viruses antiviral drugs |
| title | Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response |
| title_full | Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response |
| title_fullStr | Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response |
| title_full_unstemmed | Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response |
| title_short | Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response |
| title_sort | antimicrobial peptides as potential antiviral factors in insect antiviral immune response |
| topic | antiviral peptides antimicrobial peptides insect viruses antiviral drugs |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.02030/full |
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