Prenatal and Neonatal Pulmonary Thrombosis as a Potential Complication of SARS-CoV-2 Infection in Late Pregnancy
Neonatal venous thrombosis is a rare condition that can be iatrogenic or occur due to viral infections or genetic mutations. Thromboembolic complications are also commonly observed as a result of SARS-CoV-2 infections. They can affect pediatric patients, especially the ones suffering from multisyste...
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/8/7629 |
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| author | Gazala Abdulaziz-Opiela Anna Sobieraj Greta Sibrecht Julia Bajdor Bartłomiej Mroziński Zuzanna Kozłowska Rafał Iciek Katarzyna Wróblewska-Seniuk Ewa Wender-Ożegowska Tomasz Szczapa |
| author_facet | Gazala Abdulaziz-Opiela Anna Sobieraj Greta Sibrecht Julia Bajdor Bartłomiej Mroziński Zuzanna Kozłowska Rafał Iciek Katarzyna Wróblewska-Seniuk Ewa Wender-Ożegowska Tomasz Szczapa |
| author_sort | Gazala Abdulaziz-Opiela |
| collection | DOAJ |
| description | Neonatal venous thrombosis is a rare condition that can be iatrogenic or occur due to viral infections or genetic mutations. Thromboembolic complications are also commonly observed as a result of SARS-CoV-2 infections. They can affect pediatric patients, especially the ones suffering from multisystem inflammatory syndrome in children (MIS-C) or multisystem inflammatory syndrome in neonates (MIS-N). The question remains whether the maternal SARS-CoV-2 infection during pregnancy can lead to thromboembolic complications in fetuses and neonates. We report on a patient born with an embolism in the arterial duct, left pulmonary artery, and pulmonary trunk, who presented several characteristic features of MIS-N, suspecting that the cause might have been the maternal SARS-CoV2 infection in late pregnancy. Multiple genetic and laboratory tests were performed. The neonate presented only with a positive result of IgG antibodies against SARS-CoV-2. He was treated with low molecular weight heparin. Subsequent echocardiographic tests showed that the embolism dissolved. More research is necessary to evaluate the possible neonatal complications of maternal SARS-CoV-2 infection. |
| first_indexed | 2024-03-11T04:55:23Z |
| format | Article |
| id | doaj.art-b01ba608dc9a4eb382d0fa628297038a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:55:23Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b01ba608dc9a4eb382d0fa628297038a2023-11-17T19:43:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248762910.3390/ijms24087629Prenatal and Neonatal Pulmonary Thrombosis as a Potential Complication of SARS-CoV-2 Infection in Late PregnancyGazala Abdulaziz-Opiela0Anna Sobieraj1Greta Sibrecht2Julia Bajdor3Bartłomiej Mroziński4Zuzanna Kozłowska5Rafał Iciek6Katarzyna Wróblewska-Seniuk7Ewa Wender-Ożegowska8Tomasz Szczapa9Faculty of Medicine, Poznan University of Medical Sciences, 61-701 Poznan, PolandFaculty of Medicine, Poznan University of Medical Sciences, 61-701 Poznan, PolandII Department of Neonatology, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Radiology, Nicolaus Copernicus Hospital, 80-803 Gdansk, PolandDepartment of Pediatric Cardiology, Poznan University of Medical Sciences, 61-701 Poznan, PolandII Department of Neonatology, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Reproduction, Poznan University of Medical Sciences, 61-701 Poznan, PolandII Department of Neonatology, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Reproduction, Poznan University of Medical Sciences, 61-701 Poznan, PolandII Department of Neonatology, Poznan University of Medical Sciences, 61-701 Poznan, PolandNeonatal venous thrombosis is a rare condition that can be iatrogenic or occur due to viral infections or genetic mutations. Thromboembolic complications are also commonly observed as a result of SARS-CoV-2 infections. They can affect pediatric patients, especially the ones suffering from multisystem inflammatory syndrome in children (MIS-C) or multisystem inflammatory syndrome in neonates (MIS-N). The question remains whether the maternal SARS-CoV-2 infection during pregnancy can lead to thromboembolic complications in fetuses and neonates. We report on a patient born with an embolism in the arterial duct, left pulmonary artery, and pulmonary trunk, who presented several characteristic features of MIS-N, suspecting that the cause might have been the maternal SARS-CoV2 infection in late pregnancy. Multiple genetic and laboratory tests were performed. The neonate presented only with a positive result of IgG antibodies against SARS-CoV-2. He was treated with low molecular weight heparin. Subsequent echocardiographic tests showed that the embolism dissolved. More research is necessary to evaluate the possible neonatal complications of maternal SARS-CoV-2 infection.https://www.mdpi.com/1422-0067/24/8/7629pulmonary thrombosisSARS-CoV-2neonatal thrombosisCOVID-19 complications |
| spellingShingle | Gazala Abdulaziz-Opiela Anna Sobieraj Greta Sibrecht Julia Bajdor Bartłomiej Mroziński Zuzanna Kozłowska Rafał Iciek Katarzyna Wróblewska-Seniuk Ewa Wender-Ożegowska Tomasz Szczapa Prenatal and Neonatal Pulmonary Thrombosis as a Potential Complication of SARS-CoV-2 Infection in Late Pregnancy International Journal of Molecular Sciences pulmonary thrombosis SARS-CoV-2 neonatal thrombosis COVID-19 complications |
| title | Prenatal and Neonatal Pulmonary Thrombosis as a Potential Complication of SARS-CoV-2 Infection in Late Pregnancy |
| title_full | Prenatal and Neonatal Pulmonary Thrombosis as a Potential Complication of SARS-CoV-2 Infection in Late Pregnancy |
| title_fullStr | Prenatal and Neonatal Pulmonary Thrombosis as a Potential Complication of SARS-CoV-2 Infection in Late Pregnancy |
| title_full_unstemmed | Prenatal and Neonatal Pulmonary Thrombosis as a Potential Complication of SARS-CoV-2 Infection in Late Pregnancy |
| title_short | Prenatal and Neonatal Pulmonary Thrombosis as a Potential Complication of SARS-CoV-2 Infection in Late Pregnancy |
| title_sort | prenatal and neonatal pulmonary thrombosis as a potential complication of sars cov 2 infection in late pregnancy |
| topic | pulmonary thrombosis SARS-CoV-2 neonatal thrombosis COVID-19 complications |
| url | https://www.mdpi.com/1422-0067/24/8/7629 |
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