Simultaneous Determination of Xanthine and Hypoxanthine Using Polyglycine/rGO-Modified Glassy Carbon Electrode
A novel electrochemical sensor was developed for selective and sensitive determination of xanthine (XT) and hypoxanthine (HX) based on polyglycine (p-Gly) and reduced graphene oxide (rGO) modified glassy carbon electrode (GCE). A mixed dispersion of 7 μL of 5 mM glycine and 1 mg/mL GO was dropped on...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/3/1458 |
| _version_ | 1797623709930881024 |
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| author | Ting Wang Lin Zhang Chengyu Zhang Dongmei Deng Dejia Wang Liqiang Luo |
| author_facet | Ting Wang Lin Zhang Chengyu Zhang Dongmei Deng Dejia Wang Liqiang Luo |
| author_sort | Ting Wang |
| collection | DOAJ |
| description | A novel electrochemical sensor was developed for selective and sensitive determination of xanthine (XT) and hypoxanthine (HX) based on polyglycine (p-Gly) and reduced graphene oxide (rGO) modified glassy carbon electrode (GCE). A mixed dispersion of 7 μL of 5 mM glycine and 1 mg/mL GO was dropped on GCE for the fabrication of p-Gly/rGO/GCE, followed by cyclic voltammetric sweeping in 0.1 M phosphate buffer solution within −0.45~1.85 V at a scanning rate of 100 mV·s<sup>−1</sup>. The morphological and electrochemical features of p-Gly/rGO/GCE were investigated by scanning electron microscopy and cyclic voltammetry. Under optimal conditions, the linear relationship was acquired for the simultaneous determination of XT and HX in 1–100 μM. The preparation of the electrode was simple and efficient. Additionally, the sensor combined the excellent conductivity of rGO and the polymerization of Gly, demonstrating satisfying simultaneous sensing performance to both XT and HX. |
| first_indexed | 2024-03-11T09:32:39Z |
| format | Article |
| id | doaj.art-b01cef8239474740b2ea974a849b5fae |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T09:32:39Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b01cef8239474740b2ea974a849b5fae2023-11-16T17:32:47ZengMDPI AGMolecules1420-30492023-02-01283145810.3390/molecules28031458Simultaneous Determination of Xanthine and Hypoxanthine Using Polyglycine/rGO-Modified Glassy Carbon ElectrodeTing Wang0Lin Zhang1Chengyu Zhang2Dongmei Deng3Dejia Wang4Liqiang Luo5School of Health & Social Care, Shanghai Urban Construction Vocational College, Shanghai 201401, ChinaCollege of Sciences, Shanghai University, Shanghai 200444, ChinaCollege of Sciences, Shanghai University, Shanghai 200444, ChinaCollege of Sciences, Shanghai University, Shanghai 200444, ChinaCollege of Sciences, Shanghai University, Shanghai 200444, ChinaCollege of Sciences, Shanghai University, Shanghai 200444, ChinaA novel electrochemical sensor was developed for selective and sensitive determination of xanthine (XT) and hypoxanthine (HX) based on polyglycine (p-Gly) and reduced graphene oxide (rGO) modified glassy carbon electrode (GCE). A mixed dispersion of 7 μL of 5 mM glycine and 1 mg/mL GO was dropped on GCE for the fabrication of p-Gly/rGO/GCE, followed by cyclic voltammetric sweeping in 0.1 M phosphate buffer solution within −0.45~1.85 V at a scanning rate of 100 mV·s<sup>−1</sup>. The morphological and electrochemical features of p-Gly/rGO/GCE were investigated by scanning electron microscopy and cyclic voltammetry. Under optimal conditions, the linear relationship was acquired for the simultaneous determination of XT and HX in 1–100 μM. The preparation of the electrode was simple and efficient. Additionally, the sensor combined the excellent conductivity of rGO and the polymerization of Gly, demonstrating satisfying simultaneous sensing performance to both XT and HX.https://www.mdpi.com/1420-3049/28/3/1458polyglycinereduced graphene oxidesimultaneous determinationxanthinehypoxanthineelectrochemical sensor |
| spellingShingle | Ting Wang Lin Zhang Chengyu Zhang Dongmei Deng Dejia Wang Liqiang Luo Simultaneous Determination of Xanthine and Hypoxanthine Using Polyglycine/rGO-Modified Glassy Carbon Electrode Molecules polyglycine reduced graphene oxide simultaneous determination xanthine hypoxanthine electrochemical sensor |
| title | Simultaneous Determination of Xanthine and Hypoxanthine Using Polyglycine/rGO-Modified Glassy Carbon Electrode |
| title_full | Simultaneous Determination of Xanthine and Hypoxanthine Using Polyglycine/rGO-Modified Glassy Carbon Electrode |
| title_fullStr | Simultaneous Determination of Xanthine and Hypoxanthine Using Polyglycine/rGO-Modified Glassy Carbon Electrode |
| title_full_unstemmed | Simultaneous Determination of Xanthine and Hypoxanthine Using Polyglycine/rGO-Modified Glassy Carbon Electrode |
| title_short | Simultaneous Determination of Xanthine and Hypoxanthine Using Polyglycine/rGO-Modified Glassy Carbon Electrode |
| title_sort | simultaneous determination of xanthine and hypoxanthine using polyglycine rgo modified glassy carbon electrode |
| topic | polyglycine reduced graphene oxide simultaneous determination xanthine hypoxanthine electrochemical sensor |
| url | https://www.mdpi.com/1420-3049/28/3/1458 |
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