Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer
Cervical cancer (CC) remains a major disease burden on the female population worldwide. Chemotherapy with cisplatin (cis-diamminedichloroplatinum (II); CDDP) and related drugs are the main treatment option for CC; however, their efficacy is limited by the development of drug resistance. Noncoding RN...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2020-05-01
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| Series: | PeerJ |
| Subjects: | |
| Online Access: | https://peerj.com/articles/9234.pdf |
| _version_ | 1797425696661831680 |
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| author | Xin Wen Shui Liu Jiyao Sheng Manhua Cui |
| author_facet | Xin Wen Shui Liu Jiyao Sheng Manhua Cui |
| author_sort | Xin Wen |
| collection | DOAJ |
| description | Cervical cancer (CC) remains a major disease burden on the female population worldwide. Chemotherapy with cisplatin (cis-diamminedichloroplatinum (II); CDDP) and related drugs are the main treatment option for CC; however, their efficacy is limited by the development of drug resistance. Noncoding RNAs (ncRNAs) have been found to play critical roles in numerous physiological and pathological cellular processes, including drug resistance of cancer cells. In this review, we describe some of the ncRNAs, including miRNAs, lncRNAs and circRNAs, that are involved in the sensitivity/resistance of CC to CDDP-based chemotherapy and discuss their mechanisms of action. We also describe some ncRNAs that could be therapeutic targets to improve the sensitivity of CC to CDDP-based chemotherapy. |
| first_indexed | 2024-03-09T08:19:54Z |
| format | Article |
| id | doaj.art-b0207b26325048888381e2e39c3daa79 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T08:19:54Z |
| publishDate | 2020-05-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-b0207b26325048888381e2e39c3daa792023-12-02T21:52:40ZengPeerJ Inc.PeerJ2167-83592020-05-018e923410.7717/peerj.9234Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancerXin WenShui LiuJiyao ShengManhua CuiCervical cancer (CC) remains a major disease burden on the female population worldwide. Chemotherapy with cisplatin (cis-diamminedichloroplatinum (II); CDDP) and related drugs are the main treatment option for CC; however, their efficacy is limited by the development of drug resistance. Noncoding RNAs (ncRNAs) have been found to play critical roles in numerous physiological and pathological cellular processes, including drug resistance of cancer cells. In this review, we describe some of the ncRNAs, including miRNAs, lncRNAs and circRNAs, that are involved in the sensitivity/resistance of CC to CDDP-based chemotherapy and discuss their mechanisms of action. We also describe some ncRNAs that could be therapeutic targets to improve the sensitivity of CC to CDDP-based chemotherapy.https://peerj.com/articles/9234.pdfCervical cancerCisplatin resistanceMicroRNALong non-coding RNACircular RNANoncoding RNAs |
| spellingShingle | Xin Wen Shui Liu Jiyao Sheng Manhua Cui Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer PeerJ Cervical cancer Cisplatin resistance MicroRNA Long non-coding RNA Circular RNA Noncoding RNAs |
| title | Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer |
| title_full | Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer |
| title_fullStr | Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer |
| title_full_unstemmed | Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer |
| title_short | Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer |
| title_sort | recent advances in the contribution of noncoding rnas to cisplatin resistance in cervical cancer |
| topic | Cervical cancer Cisplatin resistance MicroRNA Long non-coding RNA Circular RNA Noncoding RNAs |
| url | https://peerj.com/articles/9234.pdf |
| work_keys_str_mv | AT xinwen recentadvancesinthecontributionofnoncodingrnastocisplatinresistanceincervicalcancer AT shuiliu recentadvancesinthecontributionofnoncodingrnastocisplatinresistanceincervicalcancer AT jiyaosheng recentadvancesinthecontributionofnoncodingrnastocisplatinresistanceincervicalcancer AT manhuacui recentadvancesinthecontributionofnoncodingrnastocisplatinresistanceincervicalcancer |