Clear Cell Adenocarcinoma of Uterine Cervix: A Single Institution Retrospective Experience
PurposeThe purpose of the study is to summarize the clinical characteristics and identify the prognosis of clear cell adenocarcinoma of the uterine cervix (CCAUC) in patients without a history of diethylstilbestrol (DES) exposure.MethodsForty-two patients with CCAUC, treated initially at Sun Yat-sen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.532748/full |
| _version_ | 1818317959773290496 |
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| author | Zhimin Liu Junyun Li Haifeng Gu Hua Tu Guochen Liu Jihong Liu |
| author_facet | Zhimin Liu Junyun Li Haifeng Gu Hua Tu Guochen Liu Jihong Liu |
| author_sort | Zhimin Liu |
| collection | DOAJ |
| description | PurposeThe purpose of the study is to summarize the clinical characteristics and identify the prognosis of clear cell adenocarcinoma of the uterine cervix (CCAUC) in patients without a history of diethylstilbestrol (DES) exposure.MethodsForty-two patients with CCAUC, treated initially at Sun Yat-sen University Cancer Center between 1985 and 2017, were studied.ResultsOf all the CCAUC patients, the median age was 47 years old, and the median tumor size was 3 cm. Thirty-four early stage patients (IB = 28, IIA = 6) underwent radical surgery. Eight advanced stage patients (IIB = 8) received concurrent chemoradiotherapy (n = 4) or radical surgery (n = 4). Survival analysis showed that patients with early stage (IB-IIA) had a significantly better 5–year progression-free survival (PFS) and overall survival (OS) than those with advanced stage (IIB) (p < 0.05). The patients with negative pelvic lymph node (PLN) had a significantly better 5-year PFS and OS than those with positive PLN (p < 0.05). Radiotherapy (RT) did not affect PFS or OS in early stage patients with intermediate risk factors (p > 0.05). Adjuvant chemotherapy (CT) did not affect PFS or OS in early stage patients without risk factors (p > 0.05).ConclusionThe FIGO stage and pelvic node status were important prognostic factors for both PFS and OS. For treatment modality, we recommended that radical surgery alone was used in early stage patients without high risk factors. Ovarian preservation in early stage patients involved some risk. |
| first_indexed | 2024-12-13T09:45:37Z |
| format | Article |
| id | doaj.art-b02204cd844a41caa72469e9e7a89ba8 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-13T09:45:37Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b02204cd844a41caa72469e9e7a89ba82022-12-21T23:52:04ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-11-011010.3389/fonc.2020.532748532748Clear Cell Adenocarcinoma of Uterine Cervix: A Single Institution Retrospective ExperienceZhimin Liu0Junyun Li1Haifeng Gu2Hua Tu3Guochen Liu4Jihong Liu5Department of Gynecologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, ChinaDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, ChinaDepartment of Gynecologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, ChinaDepartment of Gynecologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, ChinaDepartment of Gynecologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, ChinaDepartment of Gynecologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, ChinaPurposeThe purpose of the study is to summarize the clinical characteristics and identify the prognosis of clear cell adenocarcinoma of the uterine cervix (CCAUC) in patients without a history of diethylstilbestrol (DES) exposure.MethodsForty-two patients with CCAUC, treated initially at Sun Yat-sen University Cancer Center between 1985 and 2017, were studied.ResultsOf all the CCAUC patients, the median age was 47 years old, and the median tumor size was 3 cm. Thirty-four early stage patients (IB = 28, IIA = 6) underwent radical surgery. Eight advanced stage patients (IIB = 8) received concurrent chemoradiotherapy (n = 4) or radical surgery (n = 4). Survival analysis showed that patients with early stage (IB-IIA) had a significantly better 5–year progression-free survival (PFS) and overall survival (OS) than those with advanced stage (IIB) (p < 0.05). The patients with negative pelvic lymph node (PLN) had a significantly better 5-year PFS and OS than those with positive PLN (p < 0.05). Radiotherapy (RT) did not affect PFS or OS in early stage patients with intermediate risk factors (p > 0.05). Adjuvant chemotherapy (CT) did not affect PFS or OS in early stage patients without risk factors (p > 0.05).ConclusionThe FIGO stage and pelvic node status were important prognostic factors for both PFS and OS. For treatment modality, we recommended that radical surgery alone was used in early stage patients without high risk factors. Ovarian preservation in early stage patients involved some risk.https://www.frontiersin.org/articles/10.3389/fonc.2020.532748/fullcervixclear cell carcinomasurgeryradiotherapyprognosis |
| spellingShingle | Zhimin Liu Junyun Li Haifeng Gu Hua Tu Guochen Liu Jihong Liu Clear Cell Adenocarcinoma of Uterine Cervix: A Single Institution Retrospective Experience Frontiers in Oncology cervix clear cell carcinoma surgery radiotherapy prognosis |
| title | Clear Cell Adenocarcinoma of Uterine Cervix: A Single Institution Retrospective Experience |
| title_full | Clear Cell Adenocarcinoma of Uterine Cervix: A Single Institution Retrospective Experience |
| title_fullStr | Clear Cell Adenocarcinoma of Uterine Cervix: A Single Institution Retrospective Experience |
| title_full_unstemmed | Clear Cell Adenocarcinoma of Uterine Cervix: A Single Institution Retrospective Experience |
| title_short | Clear Cell Adenocarcinoma of Uterine Cervix: A Single Institution Retrospective Experience |
| title_sort | clear cell adenocarcinoma of uterine cervix a single institution retrospective experience |
| topic | cervix clear cell carcinoma surgery radiotherapy prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.532748/full |
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